Abstract:
:Lipid molecules, structural components of biomembranes, have been proposed for an important role in membrane fusion. Through various techniques based on a protein-reconstituted vesicle-vesicle fusion system, we investigated the influence of several lipid molecules on different stages of a yeast soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion process. Lipid compositions played a significant role in the early stages, docking and lipid mixing, while only exhibiting a minor effect on fusion pore formation and dilation phases, indicated by both small and large content mixing.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Lai Y,Zhao L,Bu B,Lou X,Li D,Ji B,Liu J,Diao J,Shin YKdoi
10.1088/1478-3975/12/2/025003subject
Has Abstractpub_date
2015-04-21 00:00:00pages
025003issue
2eissn
1478-3967issn
1478-3975journal_volume
12pub_type
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