Abstract:
:Based on recent experimental data, we design a model for neuronal membrane potentials that incorporates the influence of the surrounding glia (dressed neurons). A neurotransmitter released into the synaptic cleft triggers a Ca(2+) response in nearby glial cells that spreads as a Ca(2+) wave and interacts with other synapses via the release of glutamate from astrocytes. We consider the simple case of a neuron-glia circuit that consists of a single neuron that triggers a Ca(2+) response in the glial cell which in turn feeds back into synapses of the same neuron. It is shown that persistent spiking can occur if the glutamate receptors on the astrocytes are overexpressed--a condition that has been reported from patients suffering from mesial-lobe epilepsy.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Nadkarni S,Jung Pdoi
10.1088/1478-3967/1/1/004keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
35-41issue
1-2eissn
1478-3967issn
1478-3975pii
S1478-3967(04)71460-6journal_volume
1pub_type
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