Abstract:
:When motile cells come into contact with one another their motion is often considerably altered. In a process termed contact inhibition of locomotion (CIL) cells reshape and redirect their movement as a result of cell-cell contact. Here we describe a mathematical model that demonstrates that CIL alone is sufficient to produce coherent, collective cell migration. Our model illustrates a possible mechanism behind collective cell migration that is observed, for example, in neural crest cells during development, and in metastasizing cancer cells. We analyse the effects of varying cell density and shape on the alignment patterns produced and the transition to coherent motion. Finally, we demonstrate that this process may have important functional consequences by enhancing the accuracy and robustness of the chemotactic response, and factors such as cell shape and cell density are more significant determinants of migration accuracy than the individual capacity to detect environmental gradients.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Coburn L,Cerone L,Torney C,Couzin ID,Neufeld Zdoi
10.1088/1478-3975/10/4/046002subject
Has Abstractpub_date
2013-08-01 00:00:00pages
046002issue
4eissn
1478-3967issn
1478-3975journal_volume
10pub_type
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