解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::How interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image an...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/abd0db
更新日期:2020-12-04 00:00:00
abstract::Shelter-in-place and other confinement strategies implemented in the current COVID-19 pandemic have created stratified patterns of contacts between people: close contacts within households and more distant contacts between the households. The epidemic transmission dynamics is significantly modified as a consequence. W...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/abb209
更新日期:2020-10-21 00:00:00
abstract::In the intracellular environment, the intrinsic dynamics of microtubule filaments is often hindered by the presence of barriers of various kind, such as kinetochore complexes and cell cortex, which impact their polymerisation force and dynamical properties such as catastrophe rate. We present a theoretical study of th...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/abc057
更新日期:2020-10-12 00:00:00
abstract::A central question in eukaryotic cell biology asks, during cell division, how is the growth and distribution of organelles regulated to ensure each daughter cell receives an appropriate amount. For vacuoles in budding yeast, there are well described organelle-to-cell size scaling trends as well as inheritance mechanis...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aba510
更新日期:2020-10-09 00:00:00
abstract::Efficient nucleotide import is critical to fuel the reverse DNA synthesis that takes place within the HIV-1 capsid. However, the mechanism by which the HIV-1 capsid imports nucleotides is presently unclear. In this work, we carry out a series of Brownian diffusion simulations to elucidate the nucleotide import process...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/abbf32
更新日期:2020-10-07 00:00:00
abstract::Trauma arising from landmines and improvised explosive devices promotes heterotopic ossification, the formation of extra-skeletal bone in non-osseous tissue. To date, experimental platforms that can replicate the loading parameter space relevant to improvised explosive device and landmine blast wave exposure have not ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab7d1c
更新日期:2020-08-12 00:00:00
abstract::A cluster of neural crest cells (NCCs) may chemotax up a shallow external gradient to which a single cell is unresponsive. To explain this intriguing 'group advantage', we propose a chemo-mechanical model based on the signaling proteins Rac1 and RhoA. We represent each cell as a polygon with nodes connected by elastic...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab71f1
更新日期:2020-03-10 00:00:00
abstract::The majority of chronic infections are caused by biofilms, which have higher levels of antibiotic resistance than planktonic growth. Violet-blue 405 nm light has recently emerged as a novel bactericide, but limited studies have been conducted on its effectiveness against biofilms. We found that in response to 405 nm l...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab759a
更新日期:2020-03-04 00:00:00
abstract::Cell division is accompanied by dramatic changes in shape that ultimately lead to the physical separation of one cell into two. In 2D microenvironments, cells round up and remain adhered onto the substrate by thin retraction fibers during division. In contrast, in 3D environments, cells divide exhibiting long protrusi...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab4549
更新日期:2019-10-10 00:00:00
abstract::The glycolytic enzyme pyruvate kinase M2 (PKM2) exists in both catalytically inactive dimeric and active tetrameric forms. In cancer cells, PKM2 dimer predominance contributes to tumor growth by triggering glycolytic reprogramming. However, the mechanism that promotes PKM2 dimer predominance over tetramer in cancer ce...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab3f5a
更新日期:2019-09-18 00:00:00
abstract::Identifying the cues followed by cells is key to understand processes as embryonic development, tissue homeostasis, or several pathological conditions. Based on a durotaxis model, it is shown that cells moving on predeformed thin elastic membrane follow the direction of increasing strain of the substrate. This mechani...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab39c7
更新日期:2019-09-06 00:00:00
abstract::The Golgi apparatus has intrigued researchers since its discovery and despite the advances, there are still many open questions in regards to its shape and function. We propose a mechanical model of Golgi apparatus stack and explain its most elementary geometrical properties: the equilibrium number of cisternae, the s...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab3766
更新日期:2019-09-05 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process wherein polarized epithelial cells lose their junctional architecture and apical-basal polarity to become motile mesenchymal cells, and there is emerging evidence for its role in propagating tumor dissemination. While many multifaceted n...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/ab157a
更新日期:2019-05-07 00:00:00
abstract::Traditionally animal groups have been characterized by the macroscopic patterns that they form. It is now recognised that such patterns convey limited information about the nature of the aggregation as a whole. Aggregate properties cannot be determined by passive observations alone; instead one must interact with them...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/ab12b9
更新日期:2019-04-23 00:00:00
abstract::Motile biological cells in tissue often display the phenomenon of durotaxis, i.e. they tend to move towards stiffer parts of substrate tissue. The mechanism for this behavior is not completely understood. We consider simplified models for durotaxis based on the classic persistent random walker scheme. We show that eve...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aadc37
更新日期:2018-09-11 00:00:00
abstract::Particle tracking offers significant insight into the molecular mechanics that govern the behavior of living cells. The analysis of molecular trajectories that transition between different motive states, such as diffusive, driven and tethered modes, is of considerable importance, with even single trajectories containi...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aacd5a
更新日期:2018-07-06 00:00:00
abstract::Increasing numbers of physicists engage in research activities that address biological questions from physics perspectives or strive to develop physics insights from active biological processes. The on-going development and success of such activities morph our ways of thinking about what it is to 'do biophysics' and a...
journal_title:Physical biology
pub_type: 社论
doi:10.1088/1478-3975/aaca0a
更新日期:2018-07-06 00:00:00
abstract::Cells of the immune system are confronted with opposing pro- and anti-inflammatory signals. Dendritic cells (DC) integrate these cues to make informed decisions whether to initiate an immune response. Confronted with exogenous microbial stimuli, DC endogenously produce both anti- (IL-10) and pro-inflammatory (TNFα) cu...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aaaa0a
更新日期:2018-05-16 00:00:00
abstract::How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive mat...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/aab923
更新日期:2018-04-30 00:00:00
abstract::Many single-cell observables are highly heterogeneous. A part of this heterogeneity stems from age-related phenomena: the fact that there is a nonuniform distribution of cells with different ages. This has led to a renewed interest in analytic methodologies including use of the 'von Foerster equation' for predicting p...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aab0e6
更新日期:2018-03-14 00:00:00
abstract::This comment argues against the view that cancer cells produce less entropy than normal cells as stated in a recent paper by Marín and Sabater. The basic principle of estimation of entropy production rate in a living cell is discussed, emphasizing the fact that entropy production depends on both the amount of heat exc...
journal_title:Physical biology
pub_type: 评论,杂志文章
doi:10.1088/1478-3975/aa8eab
更新日期:2018-02-08 00:00:00
abstract::Engineering artificial cells to mimic one or multiple fundamental cell biological functions is an emerging area of synthetic biology. Reconstituting functional modules from biological components in vitro is a challenging yet an important essence of bottom-up synthetic biology. Here we describe the concept of building ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aa9768
更新日期:2017-12-06 00:00:00
abstract::The study on aerial plant organs (leaves and stems) motions is reviewed. The history of observations and studies is put in the perspective of the ideas surrounding them, leading to a presentation of the current classification of these motions. After showing the shortcomings of such a classification, we present, follow...
journal_title:Physical biology
pub_type: 历史文章,杂志文章,评审
doi:10.1088/1478-3975/aa5945
更新日期:2017-08-21 00:00:00
abstract::The maintenance of tissue integrity is essential for the life of multicellular organisms. Healing of a skin wound is a paradigm for how various cell types localize and repair tissue perturbations in an orchestrated fashion. To investigate biophysical mechanisms associated with wound localization, we focus on a model s...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aa6b67
更新日期:2017-06-28 00:00:00
abstract::The detection of gravity plays a fundamental role during the growth and evolution of plants. Although progress has been made in our understanding of the molecular, cellular and physical mechanisms involved in the gravity detection, a coherent scenario consistent with all the observations is still lacking. In this spec...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/aa6876
更新日期:2017-05-23 00:00:00
abstract::Monolayer expansion has generated great interest as a model system to study collective cell migration. During such an expansion the culture front often develops 'fingers', which we have recently modeled using a proposed feedback between the curvature of the monolayer's leading edge and the outward motility of the edge...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/aa6591
更新日期:2017-05-03 00:00:00
abstract::Cellular networks have been the focus of studies in modern systems biology. They are crucial in understanding cell functions and related diseases. We review some past progress in both the theory and experiments, and we also provide several future perspectives for the field. ...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/aa5b6a
更新日期:2017-02-16 00:00:00
abstract::Surface plasmon resonance (SPR) chips are widely used to measure association and dissociation rates for the binding kinetics between two species of chemicals, e.g., cell receptors and ligands. It is commonly assumed that ligands are spatially well mixed in the SPR region, and hence a mean-field rate equation descripti...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/6/066010
更新日期:2016-12-06 00:00:00
abstract::Staphylococcus aureus is an important pathogen, giving rise to antimicrobial resistance in cell strains such as Methicillin Resistant S. aureus (MRSA). Here we report an image analysis framework for automated detection and image segmentation of cells in S. aureus cell clusters, and explicit identification of their cel...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/5/055002
更新日期:2016-10-17 00:00:00
abstract::The asymmetric cell division cycle in Caulobacter crescentus is controlled by an elaborate molecular mechanism governing the production, activation and spatial localization of a host of interacting proteins. In previous work, we proposed a deterministic mathematical model for the spatiotemporal dynamics of six major r...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/3/035007
更新日期:2016-06-25 00:00:00
abstract::Gene expression is an intrinsically noisy process, typically, producing mRNAs and proteins in bursts. An important description of such stochastic processes can be done in terms of the mean first passage time (MFPT), i.e., the time taken by mRNAs/proteins to reach a particular threshold. We study the role of burstiness...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/3/036004
更新日期:2016-05-20 00:00:00
abstract::The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell types. This developmental differentiation process typically involves intracellular regulatory and stochastic mechanisms to generate cell-fate diversity as well as intercellular signaling mec...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/2/026007
更新日期:2016-05-11 00:00:00
abstract::Tumors consist of multiple cell sub-populations including cancer stem cells (CSCs), transiently amplifying cells and terminally differentiated cells (TDCs), with the CSC fraction dictating the aggressiveness of the tumor and drug sensitivity. In epithelial cancers, tumor growth is influenced greatly by properties of t...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/3/036001
更新日期:2016-04-29 00:00:00
abstract::The controlling factors that underlie the growth of tumors have often been hard to identify because of the presence in this system of a large number of intracellular biochemical parameters. Here, we propose a simplifying framework to identify the key physical parameters that govern the early growth of tumors. We model...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/2/026005
更新日期:2016-04-04 00:00:00
abstract::Several viruses exploit clathrin-mediated endocytosis to gain entry into host cells. This process is also used extensively in biomedical applications to deliver nanoparticles (NPs) to diseased cells. The internalization of these nano-objects is controlled by the assembly of a clathrin-containing protein coat on the cy...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/1/016005
更新日期:2016-02-12 00:00:00
abstract::In this article the notion of metabolic turnover is revisited in the light of recent results of out-of-equilibrium thermodynamics. By means of Monte Carlo methods we perform an exact sampling of the enzymatic fluxes in a genome scale metabolic network of E. coli in stationary growth conditions from which we infer the ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/13/1/016003
更新日期:2016-01-29 00:00:00
abstract::This paper explores the potential for simplicity to reveal new biological understanding. Borrowing selectively from physics thinking, and contrasting with Crick's reductionist philosophy, the author argues that greater emphasis on simplicity is necessary to advance biology and its applications. ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/12/6/063002
更新日期:2015-12-30 00:00:00
abstract::Type I collagen is a versatile biomaterial that is widely used in medical applications due to its weak antigenicity, robust biocompatibility, and its ability to be modified for a wide array of applications. As such, collagen has become a major component of many tissue engineering scaffolds, drug delivery platforms, an...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/12/6/061002
更新日期:2015-12-21 00:00:00
abstract::The DFT:B3LYP (6-31G** basis set) method, including the hyperfine and spin-orbit couplings (HFC and SOC, respectively), is used to study the separation of two complementary trinucleotide sequences, (dC-dG-dA)-(dG-dC-dT), upon the action of two Mg(2+) cofactors (a simplified model). The computations reveal a crossing o...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/12/6/066017
更新日期:2015-12-10 00:00:00
abstract::Cancer cells are known to modify their micro-environment such that it can sustain a larger population, or, in ecological terms, they construct a niche which increases the carrying capacity of the population. It has however been argued that niche construction, which benefits all cells in the tumour, would be selected a...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/12/5/056001
更新日期:2015-08-12 00:00:00