Memory and obesity affect the population dynamics of asexual freshwater planarians.

Abstract:

:Asexual reproduction in multicellular organisms is a complex biophysical process that is not yet well understood quantitatively. Here, we report a detailed population study for the asexual freshwater planarian Schmidtea mediterranea, which can reproduce via transverse fission due to a large stem cell contingent. Our long-term observations of isolated non-interacting planarian populations reveal that the characteristic fission waiting time distributions for head and tail fragments differ significantly from each other. The stochastic fission dynamics of tail fragments exhibits non-negligible memory effects, implying that an accurate mathematical description of future data should be based on non-Markovian tree models. By comparing the effective growth of non-interacting planarian populations with those of self-interacting populations, we are able to quantify the influence of interactions between flatworms and physical conditions on the population growth. A surprising result is the non-monotonic relationship between effective population growth rate and nutrient supply: planarians exhibit a tendency to become 'obese' if the feeding frequency exceeds a critical level, resulting in a decreased reproduction activity. This suggests that these flatworms, which possess many genes homologous to those of humans, could become a new model system for studying dietary effects on reproduction and regeneration in multicellular organisms.

journal_name

Phys Biol

journal_title

Physical biology

authors

Dunkel J,Talbot J,Schötz EM

doi

10.1088/1478-3975/8/2/026003

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

026003

issue

2

eissn

1478-3967

issn

1478-3975

pii

S1478-3975(11)69684-2

journal_volume

8

pub_type

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