Abstract:
:Protein-protein interactions are central to biology and, in this 'post-genomic era', prediction of these interactions has become the goal of many computational efforts. Close inspection of even relatively simple biological regulatory circuitry reveals multiple levels of control of the contributing protein interactions. The fundamental probability that an interaction will occur under a given set of conditions is difficult to predict because the relationship between structure and energy is not known. Layered on this basic difficulty are allosteric control mechanisms involving post-translational modification or small ligand binding. In addition, many biological processes involve multiple protein-protein interactions, some of which may be cooperative or even competitive. Finally, although the emphasis in predicting protein interactions is based on equilibrium thermodynamic principles, kinetics can be a major controlling feature in these systems. This complexity reinforces the necessity of performing detailed quantitative studies of the component interactions of complex biological regulatory systems. Results of such studies will help us to bridge the gap between our knowledge of structure and our understanding of functional biology.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Beckett Ddoi
10.1088/1478-3975/2/2/S07keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
S67-73issue
2eissn
1478-3967issn
1478-3975pii
S1478-3975(05)99522-8journal_volume
2pub_type
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