Abstract:
:A vast literature has explored the genetic interactions among the cellular components regulating gene expression in many organisms. Early on, in the absence of any biochemical definition, regulatory modules were conceived using the strict formalism of genetics to designate the modifiers of phenotype as either cis- or trans-acting depending on whether the relevant genes were embedded in the same or separate DNA molecules. This formalism distilled gene regulation down to its essence in much the same way that consideration of an ideal gas reveals essential thermodynamic and kinetic principles. Yet just as the anomalous behavior of materials may thwart an engineer who ignores their non-ideal properties, schemes to control and manipulate the genetic and epigenetic programs of cells may falter without a fuller and more quantitative elucidation of the physical and chemical characteristics of DNA and chromatin in vivo.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Levens D,Benham CJdoi
10.1088/1478-3975/8/3/035011subject
Has Abstractpub_date
2011-06-01 00:00:00pages
035011issue
3eissn
1478-3967issn
1478-3975pii
S1478-3975(11)75319-5journal_volume
8pub_type
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