Abstract:
:Intermolecular interactions became an inherent part of the structure-function paradigm. Therefore, the generalized concept of protein stability and interactions should consider the balance of stabilizing forces working in different types of intermolecular interactions. We consider here two 'extremes' of protein interactions, viral protein with high intrinsic disorder and hyperthermostable protein complexes. Intermolecular interactions provide folding upon binding as a part of function in the viral case, while they secure and stabilize specific native interfaces as a prerequisite for function in hyperthermostable complexes. We propose a generalized concept of protein stability and interactions, which includes intermolecular interactions comprising distinct combinations of stabilizing forces depending on the types of interacting partners.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Berezovsky INdoi
10.1088/1478-3975/8/3/035002subject
Has Abstractpub_date
2011-06-01 00:00:00pages
035002issue
3eissn
1478-3967issn
1478-3975pii
S1478-3975(11)72612-1journal_volume
8pub_type
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