Abstract:
:We report self-consistent Brownian dynamics simulations of a simple electrostatic model of the selectivity filters (SF) of calcium ion channels. They reveal regular structure in the conductance and selectivity as functions of the fixed negative charge Qf at the SF. With increasing Qf, there are distinct regions of high conductance (conduction bands) M0, M1, M2 separated by regions of almost zero-conductance (stop-bands). Two of these conduction bands, M1 and M2, are related to the saturated calcium occupancies of P = 1 and P = 2, respectively and demonstrate self-sustained conductivity. Despite the model's limitations, its M1 and M2 bands show high calcium selectivity and prominent anomalous mole fraction effects and can be identified with the L-type and RyR calcium channels. The non-selective band M0 can be identified with a non-selective cation channel, or with OmpF porin.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Kaufman I,Luchinsky DG,Tindjong R,McClintock PV,Eisenberg RSdoi
10.1088/1478-3975/10/2/026007subject
Has Abstractpub_date
2013-04-01 00:00:00pages
026007issue
2eissn
1478-3967issn
1478-3975journal_volume
10pub_type
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