Abstract:
:3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. In this review, the major materials and technology advances within the last five years for each of the common 3D Printing technologies (Three Dimensional Printing, Fused Deposition Modeling, Selective Laser Sintering, Stereolithography, and 3D Plotting/Direct-Write/Bioprinting) are described. Examples are highlighted to illustrate progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing.
journal_name
J Biol Engjournal_title
Journal of biological engineeringauthors
Chia HN,Wu BMdoi
10.1186/s13036-015-0001-4subject
Has Abstractpub_date
2015-03-01 00:00:00pages
4issn
1754-1611pii
1journal_volume
9pub_type
杂志文章abstract::The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., G...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-020-00236-3
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:As engineered biological systems become more complex, it is increasingly common to express multiple operons from different plasmids and inducible expression systems within a single host cell. Optimizing such systems often requires screening combinations of origins of replication, expression systems, and anti...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-5-12
更新日期:2011-09-20 00:00:00
abstract::The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting given that in most situations autografts cannot be used. The emergence of artificial skin substitutes provides...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-017-0089-9
更新日期:2017-12-13 00:00:00
abstract:Background:UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, details of UP element and binding affinity effects on transcriptional strength are unclear. Results:Her...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-017-0075-2
更新日期:2017-11-01 00:00:00
abstract::Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, causing lifelong functional deficits in cognition and behavior. The complex pathophysiology of neural injury is a primary barrier to developing sensitive and specific diagnostic tools, which consequentially has a detrimental effect...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-019-0145-8
更新日期:2019-02-19 00:00:00
abstract::Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structure without dissolving (Zhu and Marchant, Expert Rev Med Devices 8:607-626, 2011). Among the numerous polymers ...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-020-0227-7
更新日期:2020-03-13 00:00:00
abstract:BACKGROUND:In antibody purification processes, the acidic buffer commonly used to elute the bound antibodies during conventional affinity chromatograph, can damage the antibody. Herein we describe the development of several types of affinity ligands which enable the purification of antibodies under much milder conditio...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-8-15
更新日期:2014-07-01 00:00:00
abstract:UNLABELLED: BACKGROUND:Biohydrogen from cyanobacteria has attracted public interest due to its potential as a renewable energy carrier produced from solar energy and water. Anabaena siamensis TISTR 8012, a novel strain isolated from rice paddy field in Thailand, has been identified as a promising cyanobacterial strain...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-6-19
更新日期:2012-10-10 00:00:00
abstract:UNLABELLED: BACKGROUND:Traumatic spinal cord injury (SCI) leads to serious neurological and functional deficits through a chain of pathophysiological events. At the molecular level, progressive damage is initially revealed by collapse of plasma membrane organization and integrity produced by breaches. Consequently, th...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-6-18
更新日期:2012-09-14 00:00:00
abstract:BACKGROUND:Glucagon is a peptide hormone with many uses as a therapeutic agent, including the emergency treatment of hypoglycemia. Physical instability of glucagon in solution leads to problems with the manufacture, formulation, and delivery of this pharmaceutical product. Glucagon has been shown to aggregate and form ...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-2-10
更新日期:2008-07-09 00:00:00
abstract:Background:Previously we demonstrated that an entire bacterial operon (the PRN operon) is expressible in plants when driven by the Tomato -yellow-leaf-curl-virus (TYLCV) -derived universal vector IL-60.Petroleum-derived plastics are not degradable, and are therefore harmful to the environment. Fermentation of bacteria ...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-017-0062-7
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Among disposable bioreactor systems, cylindrical orbitally shaken bioreactors show important advantages. They provide a well-defined hydrodynamic flow combined with excellent mixing and oxygen transfer for mammalian and plant cell cultivations. Since there is no known universal correlation between the volume...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-7-28
更新日期:2013-12-02 00:00:00
abstract:BACKGROUND:Surface-enhanced Raman scattering (SERS) is a powerful light scattering technique that can be used for sensitive immunoassay development and cell labeling. A major obstacle to using SERS is the complexity of fabricating SERS probes since they require nanoscale characterization and optical uniformity. The lig...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-015-0023-y
更新日期:2016-01-07 00:00:00
abstract::An intestinal protozoan parasite, Cryptosporidium parvum, is a major cause of waterborne gastrointestinal disease worldwide. Detection of Cryptosporidium oocysts in potable water is a high priority for the water treatment industry to reduce potential outbreaks among the consumer populace. Anti-Cryptosporidium oocyst p...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-1-3
更新日期:2007-10-10 00:00:00
abstract:Background:With the increasing incidence of colorectal cancer (CRC), its accurate diagnosis is critical and in high demand. However, conventional methods are not ideal due to invasiveness and low accuracy. Herein, we aimed to identify efficient CRC mRNA markers in a non-invasive manner using CRC-derived extracellular v...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-020-0225-9
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation of synthetic and natural microbial communities and their underlying ecological parameters, such as f...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-3-1
更新日期:2009-01-02 00:00:00
abstract:: : Building synthetic gene networks with highly transient dynamics requires rapid protein degradation. We show that the degradation conferred by two commonly used ssrA tags is highly temperature dependent. Synthetic gene networks are being used increasingly in real-world applications where they may be subjected to va...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-6-10
更新日期:2012-07-23 00:00:00
abstract:Background:The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins in mammalian cell lines. However, these promoters are susceptible to silencing, thus limiting protei...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-019-0187-y
更新日期:2019-06-28 00:00:00
abstract:Background:Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with diabetes, the diabetic environment affected MSCs activity and could impair the efficacy of treatment. I...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-019-0163-6
更新日期:2019-05-30 00:00:00
abstract::Due to steadily growing population and economic transitions in the more populous countries, renewable sources of energy are needed more than ever. Plant biomass as a raw source of bioenergy and biofuel products may meet the demand for sustainable energy; however, such plants typically compete with food crops, which sh...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-017-0069-0
更新日期:2017-09-01 00:00:00
abstract:Background:Aptamers, single-stranded DNAs or RNAs, can be selected from a library containing random sequences using a method called Systematic Evolution of Ligands by EXponential Enrichment (SELEX). In SELEX, monitoring the enriching statuses of aptamer candidates during the process is a key step until today. Conformat...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-019-0223-y
更新日期:2020-01-13 00:00:00
abstract:UNLABELLED: BACKGROUND:Rapid increase in multi-walled carbon nanotube (MWCNT) production for their industrial and biomedical applications has led to concerns over the effects of MWCNTs on human health and the environment. Both animal and in vitro studies have provided important findings about MWCNT-induced effects on ...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-6-22
更新日期:2012-11-13 00:00:00
abstract:Background:Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated and expanded from many tissues, and are being investigated for use in cell therapies. Though MSC therapies have demonstrated some success, none have been FDA approved for clinical use. MSCs lose stemness ex vivo, decreasing therape...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-019-0140-0
更新日期:2019-01-18 00:00:00
abstract::Detecting the arbitrary movements of fast-moving insects under field conditions is notoriously difficult because existing technologies are limited by issues of size, weight, range and cost. Here, we establish proof-of-concept for a prototype long-range, passive radio frequency identification (RFID) tagging system for ...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-019-0143-x
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:Biological Computer Aided Design (bioCAD) assists the de novo design and selection of existing genetic components to achieve a desired biological activity, as part of an integrated design-build-test cycle. To meet the emerging needs of Synthetic Biology, bioCAD tools must address the increasing prevalence of...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-6-1
更新日期:2012-02-28 00:00:00
abstract:: Two current technologies used in biosensor development are very promising: 1. The sol-gel process of making microporous glass at room temperature, and 2. Using a fluorescent compound that undergoes fluorescence quenching in response to a specific analyte. These technologies have been combined to produce an iron biose...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-5-4
更新日期:2011-05-10 00:00:00
abstract:BACKGROUND:Poly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharmaceutical industry. γ-PGA is usually produced microbially by different Bacillus spp. The produced γ-P...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-017-0065-4
更新日期:2017-07-12 00:00:00
abstract:Background:Silkworm genetic engineering is widely used in gene function, silk engineering and disease-resistant engineering in most of Asia. Some of the earliest promoter elements are used to control the development of silkworm transgenic expression and gene therapy. However, the low expression and specificity of natur...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/s13036-018-0121-8
更新日期:2018-12-04 00:00:00
abstract::The ovarian follicle is the structural and functional unit of the ovary, composed of the female gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a female's germ cell supply, but also secrete important hormones necessary for proper endocrine function. Folliculogenesis, the growth a...
journal_title:Journal of biological engineering
pub_type: 杂志文章,评审
doi:10.1186/s13036-018-0134-3
更新日期:2019-01-09 00:00:00
abstract:: The following essay was written by Mr. Alex Hatch, a junior undergraduate student majoring in Biological Engineering at Utah State University. Mr. Hatch submitted a 1000-1200 word essay to the 5th Annual Bioethics Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biologic...
journal_title:Journal of biological engineering
pub_type: 杂志文章
doi:10.1186/1754-1611-4-7
更新日期:2010-06-09 00:00:00