DeviceEditor visual biological CAD canvas.

abstract：Background:UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, details of UP element and binding affinity effects on transcriptional strength are unclear. Results:Her...

journal_title：Journal of biological engineering

authors： Yan Q,Fong SS

更新日期：2017-11-01 00:00:00

abstract：UNLABELLED: BACKGROUND:Traumatic spinal cord injury (SCI) leads to serious neurological and functional deficits through a chain of pathophysiological events. At the molecular level, progressive damage is initially revealed by collapse of plasma membrane organization and integrity produced by breaches. Consequently, th...

journal_title：Journal of biological engineering

authors： Chen B,Zuberi M,Borgens RB,Cho Y

更新日期：2012-09-14 00:00:00

abstract：Background:With the increasing incidence of colorectal cancer (CRC), its accurate diagnosis is critical and in high demand. However, conventional methods are not ideal due to invasiveness and low accuracy. Herein, we aimed to identify efficient CRC mRNA markers in a non-invasive manner using CRC-derived extracellular v...

journal_title：Journal of biological engineering

authors： Cha BS,Park KS,Park JS

更新日期：2020-02-04 00:00:00

abstract：Background:Anti-CRISPR proteins are expressed by phages as a reaction to the bacterial CRISPR-Cas defense system. Recently, the structures of anti-CRISPR proteins have been determined, and their diverse functions have been clarified. Anti-CRISPR proteins such as LmAcrIIA2 and LmAcrIIA4 interact with the SpCas9:gRNA sys...

journal_title：Journal of biological engineering

authors： Li J,Xu Z,Chupalov A,Marchisio MA

更新日期：2018-08-01 00:00:00

abstract：Background:Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential to treat myocardial infarction (MI). However, in patients with diabetes, the diabetic environment affected MSCs activity and could impair the efficacy of treatment. I...

journal_title：Journal of biological engineering

authors： Meng X,Zheng M,Yu M,Bai W,Zuo L,Bu X,Liu Y,Xia L,Hu J,Liu L,Li J

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:Among disposable bioreactor systems, cylindrical orbitally shaken bioreactors show important advantages. They provide a well-defined hydrodynamic flow combined with excellent mixing and oxygen transfer for mammalian and plant cell cultivations. Since there is no known universal correlation between the volume...

journal_title：Journal of biological engineering

authors： Klöckner W,Gacem R,Anderlei T,Raven N,Schillberg S,Lattermann C,Büchs J

更新日期：2013-12-02 00:00:00

abstract：Background:This article explains some simple experiments that can be used in undergraduate or graduate physics or biomedical engineering laboratory classes to learn how birdcage volume radiofrequency (RF) coils and magnetic resonance imaging (MRI) work. For a clear picture, and to do any quantitative MRI analysis, acqu...

journal_title：Journal of biological engineering

authors： Vincent DE,Wang T,Magyar TAK,Jacob PI,Buist R,Martin M

更新日期：2017-11-02 00:00:00

abstract：Background:Oleaginous fungi are efficient tools to convert agricultural waste streams into valuable components. The filamentous fungus Mucor circinelloides was cultivated in whey permeate, a byproduct from cheese production, to produce an oil-rich fungal biomass. Response surface methodology was used to optimize the fe...

journal_title：Journal of biological engineering

authors： Chan LG,Cohen JL,Ozturk G,Hennebelle M,Taha AY,L N de Moura Bell JM

更新日期：2018-11-14 00:00:00

abstract：:Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, causing lifelong functional deficits in cognition and behavior. The complex pathophysiology of neural injury is a primary barrier to developing sensitive and specific diagnostic tools, which consequentially has a detrimental effect...

journal_title：Journal of biological engineering

authors： Martinez BI,Stabenfeldt SE

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Glucagon is a peptide hormone with many uses as a therapeutic agent, including the emergency treatment of hypoglycemia. Physical instability of glucagon in solution leads to problems with the manufacture, formulation, and delivery of this pharmaceutical product. Glucagon has been shown to aggregate and form ...

journal_title：Journal of biological engineering

authors： Hoppe CC,Nguyen LT,Kirsch LE,Wiencek JM

更新日期：2008-07-09 00:00:00

abstract：:An intestinal protozoan parasite, Cryptosporidium parvum, is a major cause of waterborne gastrointestinal disease worldwide. Detection of Cryptosporidium oocysts in potable water is a high priority for the water treatment industry to reduce potential outbreaks among the consumer populace. Anti-Cryptosporidium oocyst p...

journal_title：Journal of biological engineering

authors： Kramer MF,Vesey G,Look NL,Herbert BR,Simpson-Stroot JM,Lim DV

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation of synthetic and natural microbial communities and their underlying ecological parameters, such as f...

journal_title：Journal of biological engineering

authors： Bayer TS,Hoff KG,Beisel CL,Lee JJ,Smolke CD

更新日期：2009-01-02 00:00:00

abstract：BACKGROUND:Poly(γ-glutamic acid) (γ-PGA) is a biopolymer with many useful properties making it applicable for instance in food and skin care industries, in wastewater treatment, in biodegradable plastics or in the pharmaceutical industry. γ-PGA is usually produced microbially by different Bacillus spp. The produced γ-P...

journal_title：Journal of biological engineering

authors： Regestein Née Meissner L,Arndt J,Palmen TG,Jestel T,Mitsunaga H,Fukusaki E,Büchs J

更新日期：2017-07-12 00:00:00

abstract：: : Building synthetic gene networks with highly transient dynamics requires rapid protein degradation. We show that the degradation conferred by two commonly used ssrA tags is highly temperature dependent. Synthetic gene networks are being used increasingly in real-world applications where they may be subjected to va...

journal_title：Journal of biological engineering

authors： Purcell O,Grierson CS,Bernardo Md,Savery NJ

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Surface-enhanced Raman scattering (SERS) is a powerful light scattering technique that can be used for sensitive immunoassay development and cell labeling. A major obstacle to using SERS is the complexity of fabricating SERS probes since they require nanoscale characterization and optical uniformity. The lig...

journal_title：Journal of biological engineering

authors： Israelsen ND,Wooley D,Hanson C,Vargis E

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:As engineered biological systems become more complex, it is increasingly common to express multiple operons from different plasmids and inducible expression systems within a single host cell. Optimizing such systems often requires screening combinations of origins of replication, expression systems, and anti...

journal_title：Journal of biological engineering

authors： Lee TS,Krupa RA,Zhang F,Hajimorad M,Holtz WJ,Prasad N,Lee SK,Keasling JD

更新日期：2011-09-20 00:00:00

abstract：:3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagn...

journal_title：Journal of biological engineering

authors： Chia HN,Wu BM

更新日期：2015-03-01 00:00:00

abstract：Background:Aptamers, single-stranded DNAs or RNAs, can be selected from a library containing random sequences using a method called Systematic Evolution of Ligands by EXponential Enrichment (SELEX). In SELEX, monitoring the enriching statuses of aptamer candidates during the process is a key step until today. Conformat...

journal_title：Journal of biological engineering

authors： Liu Q,Zhang W,Chen S,Zhuang Z,Zhang Y,Jiang L,Lin JS

更新日期：2020-01-13 00:00:00

abstract：Background:Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated and expanded from many tissues, and are being investigated for use in cell therapies. Though MSC therapies have demonstrated some success, none have been FDA approved for clinical use. MSCs lose stemness ex vivo, decreasing therape...

journal_title：Journal of biological engineering

authors： Hamann A,Nguyen A,Pannier AK

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:The use of in silico simulations as a basis for designing artificial biological systems (and experiments to characterize them) is one of the tangible differences between Synthetic Biology and "classical" Genetic Engineering. To this end, synthetic biologists have adopted approaches originating from the tradi...

journal_title：Journal of biological engineering

authors： Ryback BM,Odoni DI,van Heck RG,van Nuland Y,Hesselman MC,Martins Dos Santos VA,van Passel MW,Hugenholtz F

更新日期：2013-11-18 00:00:00

abstract：:Due to steadily growing population and economic transitions in the more populous countries, renewable sources of energy are needed more than ever. Plant biomass as a raw source of bioenergy and biofuel products may meet the demand for sustainable energy; however, such plants typically compete with food crops, which sh...

journal_title：Journal of biological engineering

authors： Debez A,Belghith I,Friesen J,Montzka C,Elleuche S

更新日期：2017-09-01 00:00:00

abstract：Background:Silkworm genetic engineering is widely used in gene function, silk engineering and disease-resistant engineering in most of Asia. Some of the earliest promoter elements are used to control the development of silkworm transgenic expression and gene therapy. However, the low expression and specificity of natur...

journal_title：Journal of biological engineering

authors： Dong ZQ,Hu ZG,Li HQ,Jiang YM,Cao MY,Chen P,Lu C,Pan MH

更新日期：2018-12-04 00:00:00

abstract：:The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting given that in most situations autografts cannot be used. The emergence of artificial skin substitutes provides...

journal_title：Journal of biological engineering

authors： Dixit S,Baganizi DR,Sahu R,Dosunmu E,Chaudhari A,Vig K,Pillai SR,Singh SR,Dennis VA

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:The Hamiltonian Path Problem asks whether there is a route in a directed graph from a beginning node to an ending node, visiting each node exactly once. The Hamiltonian Path Problem is NP complete, achieving surprising computational complexity with modest increases in size. This challenge has inspired resear...

journal_title：Journal of biological engineering

authors： Baumgardner J,Acker K,Adefuye O,Crowley ST,Deloache W,Dickson JO,Heard L,Martens AT,Morton N,Ritter M,Shoecraft A,Treece J,Unzicker M,Valencia A,Waters M,Campbell AM,Heyer LJ,Poet JL,Eckdahl TT

更新日期：2009-07-24 00:00:00

abstract：:In situ tissue regeneration approach aims to exploit the body's own biological resources and reparative capability and recruit host cells by utilizing cell-instructive biomaterials. In order to immobilize and release bioactive factors in biomaterials, it is important to engineer the load effectiveness, release kinetic...

journal_title：Journal of biological engineering

authors： Zhao W,Jin K,Li J,Qiu X,Li S

更新日期：2017-06-29 00:00:00

abstract：: Two current technologies used in biosensor development are very promising: 1. The sol-gel process of making microporous glass at room temperature, and 2. Using a fluorescent compound that undergoes fluorescence quenching in response to a specific analyte. These technologies have been combined to produce an iron biose...

journal_title：Journal of biological engineering

authors： Yoder MF,Kisaalita WS

更新日期：2011-05-10 00:00:00

abstract：Background:Inulinase can hydrolyze polyfructan into high-fructose syrups and fructoligosaccharides, which are widely used in food, the medical industry and the biorefinery of Jerusalem artichoke. In the present study, a recombinant exo-inulinase (rKcINU1), derived from Kluyveromyces cicerisporus CBS4857, was proven as ...

journal_title：Journal of biological engineering

authors： Ma J,Li Q,Tan H,Jiang H,Li K,Zhang L,Shi Q,Yin H

更新日期：2019-10-29 00:00:00

abstract：: The following essay was written by Mr. Alex Hatch, a junior undergraduate student majoring in Biological Engineering at Utah State University. Mr. Hatch submitted a 1000-1200 word essay to the 5th Annual Bioethics Contest sponsored by the Institute of Biological Engineering (IBE). A group of professionals in Biologic...

journal_title：Journal of biological engineering

authors： Hatch AD

更新日期：2010-06-09 00:00:00

abstract：:Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structure without dissolving (Zhu and Marchant, Expert Rev Med Devices 8:607-626, 2011). Among the numerous polymers ...

journal_title：Journal of biological engineering

authors： Abasalizadeh F,Moghaddam SV,Alizadeh E,Akbari E,Kashani E,Fazljou SMB,Torbati M,Akbarzadeh A

更新日期：2020-03-13 00:00:00

abstract：Background:The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins in mammalian cell lines. However, these promoters are susceptible to silencing, thus limiting protei...

journal_title：Journal of biological engineering

authors： Zúñiga RA,Gutiérrez-González M,Collazo N,Sotelo PH,Ribeiro CH,Altamirano C,Lorenzo C,Aguillón JC,Molina MC

更新日期：2019-06-28 00:00:00