cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.

abstract：:We have previously described how T and natural killer (NK) lineage commitment proceeds from common T/NK progenitors (p-T/NK) in the murine fetal thymus (FT), with the use of a clonal assay system capable of discriminating p-T/NK from unipotent T or NK lineage-committed progenitors (p-T and p-NK, respectively). The mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikawa T,Fujimoto S,Kawamoto H,Katsura Y,Yokota Y

更新日期：2001-04-24 00:00:00

abstract：:The small-component origins of herpes simplex virus 1 DNA synthesis are transcribed late in infection by an RNA with heterogeneous initiation sites approximately 290-360 base pairs from the origins. We report that cellular proteins react with a labeled RNA probe representing the 5' terminus of a subset of this RNA but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roller RJ,McCormick AL,Roizman B

更新日期：1989-09-01 00:00:00

abstract：:It has been proposed that horizontal cells of the vertebrate retina have a negative feedback synapse with cone photoreceptors. gamma-Aminobutyric acid (GABA) has been suggested to be a neurotransmitter of monophasic horizontal cells (a subtype of horizontal cells), which have direct connections with red-sensitive and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachibana M,Kaneko A

更新日期：1984-12-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans, with case fatality rates approaching 75%. NiV contains two envelope glycoproteins, the receptor-binding G glycoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu K,Rajashankar KR,Chan YP,Himanen JP,Broder CC,Nikolov DB

更新日期：2008-07-22 00:00:00

abstract：:In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barducci A,Bonomi M,Prakash MK,Parrinello M

更新日期：2013-12-03 00:00:00

abstract：:Many bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS) signals in modulation of virulence and biofilm formation. Previous work on Xanthomonas campestris showed that the RpfC/RpfG two-component system is involved in sensing and responding to DSF signals, but little is known in other mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng Y,Schmid N,Wang C,Wang J,Pessi G,Wu D,Lee J,Aguilar C,Ahrens CH,Chang C,Song H,Eberl L,Zhang LH

更新日期：2012-09-18 00:00:00

abstract：:The rat calbindin D-9k gene is transcriptionally regulated by 1,25-dihydroxyvitamin D3 in the intestine. We have examined the 5'-flanking region of this gene and identified a 1,25-dihydroxyvitamin D3-responsive element (DRE) between nucleotides -489 and -445. This element confers 1,25-dihydroxyvitamin D3 responsivenes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Darwish HM,DeLuca HF

更新日期：1992-01-15 00:00:00

abstract：:The development of Drosophila requires the function of the CREB-binding protein, dCBP. In flies, dCBP serves as a coactivator for the transcription factors Cubitus interruptus, Dorsal, and Mad, and as a cosuppressor of Drosophila T cell factor. Current models propose that CBP, through its intrinsic and associated hist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bantignies F,Goodman RH,Smolik SM

更新日期：2002-03-05 00:00:00

abstract：:Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the oute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dovala D,Rath CM,Hu Q,Sawyer WS,Shia S,Elling RA,Knapp MS,Metzger LE 4th

更新日期：2016-10-11 00:00:00

abstract：:Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashimoto H,Nomura M

更新日期：1970-11-01 00:00:00

abstract：:The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are important mediator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones MF,Hara T,Francis P,Li XL,Bilke S,Zhu Y,Pineda M,Subramanian M,Bodmer WF,Lal A

更新日期：2015-03-31 00:00:00

abstract：:A debate has recently surfaced concerning the degree of precommitment attained by alpha beta and gamma delta T-cell precursors prior to T-cell receptor (TCR) gene rearrangement. It has been suggested that precursors may be precommitted to rearrange either alpha or delta genes, but not both, thus giving rise to alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson SD,Pelkonen J,Hurwitz JL

更新日期：1990-07-01 00:00:00

abstract：:Cyanobacteria, blue-green algae, are the most abundant autotrophs in aquatic environments and form the base of all aquatic food chains by fixing carbon and nitrogen into cellular biomass. The single most important nutrient for photosynthesis and growth is nitrate, which is severely limiting in many aquatic environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koropatkin NM,Pakrasi HB,Smith TJ

更新日期：2006-06-27 00:00:00

abstract：:The oligodendrocyte (Od), a glial cell that produces myelin in the central nervous system, may be a target for autoreactive T cells in autoimmune demyelinating processes, although not expressing major histocompatibility complex (MHC) products. To analyze Od-T-cell interactions, we selected from normal SJL/J mouse sple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jewtoukoff V,Lebar R,Bach MA

更新日期：1989-04-01 00:00:00

abstract：:In mantle cell lymphoma (MCL), the translocation t(11;14) is considered the cytogenetic hallmark of the disease. Recently, however, deletion of the chromosomal region 11q22-q23 has been identified as a frequent event in this type of cancer, indicating the existence of a pathogenically relevant tumor suppressor gene in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaffner C,Idler I,Stilgenbauer S,Döhner H,Lichter P

更新日期：2000-03-14 00:00:00

abstract：:The genomic sequences encoding the human lysosomal acid lipase/cholesteryl esterase (sterol esterase; EC 3.1.1.13) have been isolated and sequenced, and the information has been used to identify mutations in both alleles of the gene from a patient with Wolman disease, an autosomal recessive lysosomal lipid storage dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson RA,Byrum RS,Coates PM,Sando GN

更新日期：1994-03-29 00:00:00

abstract：:In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbertson LA,Stahl FW

更新日期：1994-12-06 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role in neurotransmitter release at the neuronal synapse. Here, the SNARE proteins are essential by forming the SNARE complex that drives vesicular membrane fusion. While it is widely accepted that the SNARE proteins are in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lakomek NA,Yavuz H,Jahn R,Pérez-Lara Á

更新日期：2019-04-30 00:00:00

abstract：:Human neutrophils respond to chemoattractants, resulting in their accumulation at an inflammatory site. Chemoattractants such as the C5a peptide, derived from the C5 complement factor, bind to inhibitory guanine nucleotide binding protein (Gi)-coupled seven membrane-spanning receptors expressed in neutrophils. C5a rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buhl AM,Avdi N,Worthen GS,Johnson GL

更新日期：1994-09-13 00:00:00

abstract：:Controlling the effects of proactive interference (PI), the deleterious effect of prior mental activity on current memory representations, is believed to be a key function of the prefrontal cortex. This view is supported by neuroimaging evidence for a correlation between the longer reaction times caused by high PI con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feredoes E,Tononi G,Postle BR

更新日期：2006-12-19 00:00:00

abstract：:The image that best expresses Darwin's thinking is the tree of life. However, Darwin's human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our own species. Darwin believed that the root of the human tree was very deep ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL

更新日期：2010-05-11 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00

abstract：:The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seki T,Spurr N,Obata F,Goyert S,Goodfellow P,Silver J

更新日期：1985-10-01 00:00:00

abstract：:Crystals of magnetite (Fe(3)O(4)) and periclase (MgO) in Fe-Mg-Ca carbonate in the Martian meteorite Allan Hills 84001 were studied by using transmission electron microscopy to understand their origin and evaluate claims that the magnetites were made by Martian microorganisms. In magnesian carbonate, periclase occurs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber DJ,Scott ER

更新日期：2002-05-14 00:00:00

abstract：:Bone marrow mononuclear cells (BMC) from patients with ischemic cardiomyopathy (ICMP) show a reduced neovascularization capacity in vivo. NO plays an important role in neovascularization, and NO bioavailability is typically reduced in patients with ICMP. We investigated whether the impaired neovascularization capacity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasaki K,Heeschen C,Aicher A,Ziebart T,Honold J,Urbich C,Rossig L,Koehl U,Koyanagi M,Mohamed A,Brandes RP,Martin H,Zeiher AM,Dimmeler S

更新日期：2006-09-26 00:00:00

abstract：:The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LM,Bollum FJ

更新日期：1970-04-01 00:00:00

abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

更新日期：2020-08-04 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:Hypertension, a remediable risk factor for stroke, cardiovascular disease, and renal failure, affects 50 million individuals in the United States alone. African Americans (blacks) have a higher incidence and prevalence of hypertension and hypertension-associated target organ damage compared with Caucasian Americans (w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suthanthiran M,Li B,Song JO,Ding R,Sharma VK,Schwartz JE,August P

更新日期：2000-03-28 00:00:00

abstract：:We have measured high-resolution x-ray absorption spectra of lanthanide (Ln) and heavy transition metal complexes that display prominent narrow absorption peaks near the L2 and L3 absorption edges. The anomalous scattering factors (f' and f"), which are mathematically related to the absorption cross section, have corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lye RC,Phillips JC,Kaplan D,Doniach S,Hodgson KO

更新日期：1980-10-01 00:00:00