Salvage pancreaticoduodenectomy after complete response to chemoradiotherapy for a previously unresectable pancreatic adenosquamous carcinoma: a case report.

Abstract:

:Pancreatic cancer is known for its typically late presentation and poor survival rates, with overall 5-year survival of less than 5%. The role of chemotherapy alone or with radiotherapy in the management of locally advanced tumors continues to be an area of debate.We report a case of locally advanced, pancreatic adenosquamous carcinoma that was initially deemed unresectable intraoperatively. Nonetheless, the tumor was resected after radiological response to gemcitabine-capecitabine chemoradiotherapy regimen similar to the Selective Chemoradiation in Advanced LOcalised Pancreatic cancer trial. Histological examination revealed complete pathological response with extensive fibrosis (ypT0 N0). On 12-month follow-up CT, a single liver lesion in the left lateral segment was identified and confirmed to be a metastasis with cytological diagnosis via EUS and FNA. The disease remained stable and confined to the solitary hepatic metastasis after further gemcitabine chemotherapy. Therefore, a further successful resection was performed.The 2 main strategies for the management of locally advanced unresectable pancreatic cancer are chemotherapy induction followed by consolidation chemoradiotherapy or chemotherapy alone, with conflicting published evidence. Evidence for the optimal management of the rare histological type of adenosquamous carcinoma is scant. We present a case of such tumor with a complete pathological response to chemoradiotherapy. The results of future studies in the area are eagerly awaited.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Elias A,Chatzizacharias NA,Xanthis A,Corrie P,Davies S,Brais RJ,Jamieson NV,Praseedom RK,Huguet E,Harper SJF,Jah A

doi

10.1097/MD.0000000000000499

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

e499

issue

6

eissn

0025-7974

issn

1536-5964

pii

00005792-201502020-00011

journal_volume

94

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature.

    abstract::Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-198007000-00006

    authors: Bardwick PA,Zvaifler NJ,Gill GN,Newman D,Greenway GD,Resnick DL

    更新日期:1980-07-01 00:00:00

  • The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population.

    abstract::Dyslipidemia is one of the most important factors for coronary artery disease (CAD). The atherogenic index of plasma (AIP), a new comprehensive lipid index, might be a strong marker for predicting the risk of CAD.A hospital-based case-control study including 2936 CAD patients and 2451 controls was conducted in a Chine...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008058

    authors: Cai G,Shi G,Xue S,Lu W

    更新日期:2017-09-01 00:00:00

  • Natural history of adults with congenitally malformed aortic valves (unicuspid or bicuspid).

    abstract::Appreciation of the frequency of the congenitally malformed aortic valve has come about during the last 50 years, a period during which aortic valve replacement became a predictably successful operation. Study of patients at necropsy with either a congenitally unicuspid (1 true commissure) or bicuspid (2 true commissu...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0b013e3182764b84

    authors: Roberts WC,Vowels TJ,Ko JM

    更新日期:2012-11-01 00:00:00

  • Efficacy and safety of traditional Chinese medicine for erosive oral lichen planus: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:Oral lichen planus (OLP) is a common disease among oral mucous membrane diseases. Erosive oral lichen planus (EOLP) is a type of OLP, it has a potential tendency of cancerization. There have been some randomized controlled trials (RCTs) using Traditional Chinese Medicine (TCM) to treat EOLP. No systematic re...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023375

    authors: You Y,Huang X,Chen Y,You Y

    更新日期:2020-11-25 00:00:00

  • Pain relieving effect of dexmedetomidine in patients undergoing total knee or hip arthroplasty: A meta-analysis.

    abstract:BACKGROUND:To evaluate the safety and efficacy of dexmedetomidine in patients undergoing total knee and hip arthroplasty for postoperative pain control. METHODS:An updated systematic review and meta-analysis of randomized controlled trials (RCTs) identified in systematic searches of MEDLINE, EMBASE, Google Scholar, th...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000018538

    authors: Yang Q,Ren Y,Feng B,Weng X

    更新日期:2020-01-01 00:00:00

  • Acute and Chronic Pheochromocytoma-Induced Cardiomyopathies: Different Prognoses?: A Systematic Analytical Review.

    abstract::Pheochromocytoma and paraganglioma (PPG) are rare and late-diagnosed catecholamine secreting tumors, which may be associated with unrecognized and/or severe cardiomyopathies. We performed a computer-assisted systematic search of the electronic Medline databases using the MESH terms "myocarditis," "myocardial infarctio...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000002198

    authors: Batisse-Lignier M,Pereira B,Motreff P,Pierrard R,Burnot C,Vorilhon C,Maqdasy S,Roche B,Desbiez F,Clerfond G,Citron B,Lusson JR,Tauveron I,Eschalier R

    更新日期:2015-12-01 00:00:00

  • The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies.

    abstract:BACKGROUND:The single nucleotide polymorphism (SNP) rs2476601 of the protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) gene has been presented to implicate in the pathogenesis of alopecia areata (AA) in a few association investigations with limited sample size and inconsistent conclusions. METHODS:The aim of ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000015448

    authors: Lei ZX,Chen WJ,Liang JQ,Wang YJ,Jin L,Xu C,Kang XJ

    更新日期:2019-05-01 00:00:00

  • Correlation of cervical and thoracic inlet sagittal parameters by MRI and radiography in patients with cervical spondylosis.

    abstract::To investigate the relationship between cervical and thoracic sagittal alignment parameters measured by magnetic resonance imaging (MRI) and x-ray in patients with cervical spondylosisData from 120 symptomatic patients who presented with cervical spondylosis between April 2015 and January 2016 were retrospectively ana...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014393

    authors: Cheng J,Liu P,Sun D,Ma Z,Liu J,Wang Z,Mou J

    更新日期:2019-02-01 00:00:00

  • Clinicopathological features and surgical options for synchronous colorectal cancer.

    abstract::This study was conducted to investigate the clinicopathological features of synchronous cancers and treatment options according to their locations.Records of 8368 patients with colorectal cancer treated at our center between July 2003 and December 2010 were analyzed retrospectively. All synchronous colorectal cancer p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006224

    authors: Lee BC,Yu CS,Kim J,Lee JL,Kim CW,Yoon YS,Park IJ,Lim SB,Kim JC

    更新日期:2017-03-01 00:00:00

  • Herbal medicine (zhishi xiebai guizhi decoction) for unstable angina: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Unstable angina (UA) is a clinically common coronary heart disease. Zhishi xiebai guizhi decoction (ZXGD) has been widely used in the management of UA, although its effective evidence is not clear and there is no systematic review regarding its efficacy and safety. Therefore, we conduct this systematic revie...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000013965

    authors: Tang Y,Cai H,Zhan Z,Luo Y,Huang Y,Chen D,Chen B

    更新日期:2018-12-01 00:00:00

  • Delayed Intracerebral Hemorrhage Secondary to Ventriculoperitoneal Shunt: A Case Report and Literature Review.

    abstract::The ventriculoperitoneal (VP) shunt is a routine procedure for cerebrospinal fluid (CSF) diversion, and is associated with many complications. A delayed hemorrhage after the VP shunt surgery, however, is quite rare. In this study, we report a case involving late-onset hemorrhage. The 67-year-old male patient with a hi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002029

    authors: Ma L,Chen YL,Yang SX,Wang YR

    更新日期:2015-11-01 00:00:00

  • Long-term outcome of idiopathic pulmonary hemosiderosis in children.

    abstract::We retrospectively analyzed the long-term outcome of idiopathic pulmonary hemosiderosis (IPH) in 15 children. IPH started at a mean age of 5 years, and the mean duration of follow-up was 17.2 years (range, 10-36 yr). Four patients developed immune disorders, 3 cases of rheumatoid polyarthritis or rheumatoid polyarthri...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-200009000-00005

    authors: Le Clainche L,Le Bourgeois M,Fauroux B,Forenza N,Dommergues JP,Desbois JC,Bellon G,Derelle J,Dutau G,Marguet C,Pin I,Tillie-Leblond I,Scheinmann P,De Blic J

    更新日期:2000-09-01 00:00:00

  • Traditional Chinese medicine on treating pain caused by prostate cancer: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Prostate cancer is a male malignant tumor disease with high prevalence in recent years. Patients with advanced prostate cancer are more likely to have bone metastasis and have strong bone pain, and even lead to pathological fracture, which has a serious impact on the quality of life of patients. Traditiona...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017624

    authors: Wang N,Xu L,Wang JS,Yu XD,Chu LY,Deng S,Ge FX,Li HS

    更新日期:2019-11-01 00:00:00

  • Is allograft a more reliable treatment option than autograft in 2-level anterior cervical discectomy and fusion with plate fixation?

    abstract::This study aimed to assess the efficacy of allograft in 2-level anterior cervical discectomy and fusion (ACDF) with plate fixation by comparing its clinical and radiological outcomes to those of autograft.Thirty five patients with femur cortical allografts and 32 patients with tricortical iliac autografts were evaluat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016621

    authors: Park JS,Park SJ,Lee CS,Chung SS,Park HJ

    更新日期:2019-08-01 00:00:00

  • Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy.

    abstract::This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures.Anal fissures are a common cause of anal pain. Conventional treatments include nonsteroidal anti-inflammatory drugs, topical creams, such as nitroglycerin an...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006853

    authors: Hang MTH,Smith BE,Keck C,Keshavarzian A,Sedghi S

    更新日期:2017-05-01 00:00:00

  • Evaluation of intrathecal drug delivery system for intractable pain in advanced malignancies: A prospective cohort study.

    abstract::Pain is prevalent in advanced malignancies; however, some patients cannot get adequate pain relief by conservative routes of analgesic administration or experience serious side effects related to high dose of opioids. For those who have exhausted multimodal conservative analgesic, intrathecal drug delivery is an alter...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006354

    authors: Zheng S,He L,Yang X,Li X,Yang Z

    更新日期:2017-03-01 00:00:00

  • Failed percutaneous kyphoplasty in treatment of stage 3 Kummell disease: A case report and literature review.

    abstract:RATIONALE:Albeit it is rare, the authors report a stage 3 Kummell disease case. It is diagnosed by dynamic thoracic magnetic resonance imaging (MRI). Because there is no established strategy on stage 3 Kummell disease, we performed percutaneous kyphoplasty at first, but unfortunately made a revision surgery to remove t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008895

    authors: Zhang C,Wang G,Liu X,Li Y,Sun J

    更新日期:2017-11-01 00:00:00

  • Injury of the cortico-ponto-cerebellar tract in a patient with mild traumatic brain injury: A case report.

    abstract:RATIONALE:We report on a patient with injury of the cortico-ponto-cerebellar tract (CPCT) following mild traumatic brain injury (TBI), diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS:A 53-year-old female patient was injured in a car crash. While under treatment at a local medical center for headache...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008749

    authors: Jang SH,Kwon HG

    更新日期:2017-12-01 00:00:00

  • Decreased cord blood estradiol levels in related to mothers with gestational diabetes.

    abstract::Recent studies have revealed a link between estradiol (E2) and glucose homeostasis. We aimed to assess the association between cord blood hormone levels and the risk of gestational diabetes mellitus (GDM).A total of 204 pregnant women with GDM and 204 pregnant women without GDM (control) were included in the study. Ma...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006962

    authors: Qi X,Gong B,Yu J,Shen L,Jin W,Wu Z,Wang J,Wang J,Li Z

    更新日期:2017-05-01 00:00:00

  • A case report: identification of a novel exon 1 deletion mutation in the GNE gene in a Chinese patient with GNE myopathy.

    abstract:RATIONALE:GNE myopathy is caused by mutations in the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase(GNE) gene and is clinically characterized by progressive weakness and atrophy of the lower-limb muscles with quadriceps sparing. Nearly all GNE mutations that have been reported thus far in various ethnic...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022663

    authors: Miao J,Wei XJ,Wang X,Yin X,Yu XF

    更新日期:2020-10-09 00:00:00

  • Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chine...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020984

    authors: Liu Z,Dong Y,Zhu M,Mu Y,Chen L

    更新日期:2020-06-26 00:00:00

  • Phenotype of NK Cells Determined on the Basis of Selected Immunological Parameters in Children Treated due to Acute Lymphoblastic Leukemia.

    abstract::Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. The chemotherapy for ALL is associated with a profound secondary immune deficiency.We evaluated the number and phenotype of natural killer (NK) cells at diagnosis, after the intensive chemotherapy and following the completion of the entire t...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002369

    authors: Koltan S,Debski R,Koltan A,Grzesk E,Tejza B,Eljaszewicz A,Gackowska L,Kubicka M,Kolodziej B,Kurylo-Rafinska B,Kubiszewska I,Wiese M,Januszewska M,Michalkiewicz J,Wysocki M,Styczynski J,Grzesk G

    更新日期:2015-12-01 00:00:00

  • Anti-angiogenesis treatment in a patient with appendix metastasis of small cell lung cancer: A case report.

    abstract:RATIONALE:Small-cell lung cancer (SCLC) is a common pathological type of lung cancer, but appendiceal metastasis of SCLC was rare. At present, clinical studies on the maintenance therapy of SCLC have not reached a significant conclusion. PATIENT CONCERNS:We reported on a 52-year-old man who diagnosed as extensive stag...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015333

    authors: Xue P,Wang N,Mao Y,Zhu S

    更新日期:2019-04-01 00:00:00

  • Association of Migraine and Sleep-Related Breathing Disorder: A Population-Based Cohort Study.

    abstract::In this nationwide population-based cohort study, we aimed to evaluate the effects of sleep-related breathing disorders (SBD) on migraine development.Patients ages 20 years or more and diagnosed with SBD between 2000 and 2009 were evaluated as the SBD cohort (n = 3411), and compared with comparison cohort (n = 13,644)...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001506

    authors: Harnod T,Wang YC,Kao CH

    更新日期:2015-09-01 00:00:00

  • Remnant lymph node metastases after neoadjuvant therapy and surgery in patients with pathologic T0 esophageal carcinoma impact on prognosis: A systematic review and meta-analysis.

    abstract:BACKGROUND:The aim of this study was to evaluate the outcomes of patients with pathologic T0 esophageal carcinoma after neoadjuvant therapy and surgery. METHODS:We searched PubMed, Embase, Cochrane Library, and Medline databases from inception up to November 12, 2016. The meta-analysis was performed to compare odds ra...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000007342

    authors: Lv HW,Li Y,Zhou MH,Cheng JW,Xing WQ

    更新日期:2017-06-01 00:00:00

  • CONSORT-Independent prognostic value of asphericity of pretherapeutic F-18 FDG uptake by primary tumors in patients with breast cancer.

    abstract:BACKGROUND:The aim of this study was to evaluate the prognostic implication of asphericity (ASP); spatial irregularity; of pretherapeutic F 2-deoxy-2-fluoro-D-glucose (F FDG) tumor uptake in patients with invasive ductal carcinoma (IDC) of the breast. METHODS:One hundred thirty-one female IDC patients (mean age = 48.1...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000008438

    authors: Jung JH,Son SH,Kim DH,Lee J,Jeong SY,Lee SW,Park HY,Lee J,Ahn BC

    更新日期:2017-11-01 00:00:00

  • A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis.

    abstract::Uremic pruritus is common and bothersome in patients receiving either peritoneal dialysis (PD) or hemodialysis (HD). To date, the preferred dialysis modality regarding the alleviation of uremic pruritus remains controversial. We conducted this cross-sectional study to compare the prevalence, intensity, and characteris...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002935

    authors: Wu HY,Peng YS,Chen HY,Tsai WC,Yang JY,Hsu SP,Pai MF,Lu HM,Chiang JF,Ko MJ,Wen SY,Chiu HC

    更新日期:2016-03-01 00:00:00

  • Burnout level and job satisfaction in Chinese pediatrics residents: A web-based cross-sectional study.

    abstract::To study the prevalence of burnout and job satisfaction in Chinese pediatrics residents.Prospective participants were invited via a WeChat group to participate from October 1, 2018 to January 31, 2019. The Maslach Burnout Inventory-Human Services Survey was used to measure physician burnout, and the Minnesota Satisfac...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019249

    authors: Ji L,Xiaowei Z,Ling K,Yao F,Qingkun S,Jun Z

    更新日期:2020-02-01 00:00:00

  • Primary cutaneous anaplastic large-cell lymphoma: A case report.

    abstract:RATIONALE:Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface. PATIENT CONCERNS:This is the case of a 73-year-old man who r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009645

    authors: Abed K,Stopa Z,Siewert-Gutowska M

    更新日期:2018-01-01 00:00:00

  • Noncystoscopic removal of retained ureteral stents in children: A retrospective study from a single-center.

    abstract::Cystoscopic technique is the current common method of retrieving double J ureteral stent in most pediatric urological centers. In this study, we evaluated the feasibility and efficacy of a novel noncystoscopic method to remove retained ureteral stents in pediatric patients.We reviewed all medical records from a total ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009540

    authors: Shao H,Liu P,Zhang H,Chen C,Lin X

    更新日期:2018-01-01 00:00:00