Abstract：
:The effectiveness of low-molecular weight heparin CY 216 in the prophylaxis of fatal pulmonary embolism in patients undergoing general surgery was assessed in a multicentre, double-blind, randomized, clinical trial against placebo. A total of 4,498 patients aged over 40 undergoing general surgery were enrolled in the 18 centres which took part in the trial. Patients received a single daily subcutaneous injection of 7,500 anti-Xa units I.C. of CY 216 or placebo two hours before surgery, 12 hours after the initial injection and then daily for at least seven days. A post-mortem examination had to be carried out in every patient who died. The two groups of patients were well-matched for age, sex, type of disease, site and duration of operation as well as for incidence of risk factors which could predispose to the development of thromboembolism. Twenty-six deaths were recorded and validated: eight (0.36%) in the CY 216 group and 18 (0.80%) in the placebo group (p less than 0.05). At the post-mortem examination, carried out in 23 patients (88.5%), two deaths were found to be directly due to pulmonary embolism (0.09%) in the CY 216 group and four (0.18%) in the placebo group. Pulmonary embolism contributed to death in four other placebo-treated patients. Pulmonary or extrapulmonary thromboembolism was a significantly less frequent direct cause of death (p less than 0.05) in the CY 216 group (two pulmonary embolisms) than in the placebo group (four pulmonary embolisms, one acute myocardial infarction, one disseminated intravascular coagulation, two ischemic cerebral strokes).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int Surgjournal_title
International surgeryauthors
Pezzuoli G,Neri Serneri GG,Settembrini P,Coggi G,Olivari N,Buzzetti G,Chierichetti S,Scotti A,Scatigna M,Carnovali Msubject
Has Abstractpub_date
1989-10-01 00:00:00pages
205-10issue
4eissn
0020-8868issn
2520-2456journal_volume
74pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:One hundred cases of malignant tumors of the larynx, pharynx, oral cavity, nose and paranasal sinuses were studied. The hypopharynx was the most frequent site and the most common type of tumor was squamous cell carcinoma. Lymph nodes were palpable in 59% of cases, of which 72.8% showed histological evidence of metasta...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:Among the causes of male infertility, the varicocele accounts for 40%. Videolaparoscopic varicocelectomy was used for the treatment of 800 men as day surgery cases. The operation enabled high bilateral ligation, with an average operating time of 1.5 hours. Operative difficulties were minor being colon adhesions, vascu...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Massive lower gastrointestinal hemorrhage originates in the colon in 70% of cases. In half the remaining cases it originates in the small bowel, and in the other half in the duodenum. Currently available diagnostic techniques are: mesenteric angiography, barium contrast meal studies, colonoscopy, and laparotomy. Cause...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:This preliminary study included five patients with a history of haematemesis resulting from rupture of oesophageal varices complicating schistosomal hepatic fibrosis. Simultaneous measurements were taken of the endoscopic variceal pressure (EVP) and the free portal pressure (FPP) obtained by the cannulation of a mesen...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Fifteen patients with 16 histologically verified heterotopic pancreas lesions were encountered at our department during a period of 22 years. The incidence was 0.25% of the findings of all abdominal operations during the same period. Heterotopic pancreas caused symptoms in 5 patients. All the remaining 10 patients wer...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The diagnostic and therapeutic problems involved in 29 cases of isolated hepatic tumors have been presented. In nine cases the hepatoma was discovered during emergency treatment for complications. Selective arteriography was the most accurate method of establishing the etiologic diagnosis. Suprahepatic phlebography in...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：:At present imaging techniques and laboratory tests are employed very extensively to investigate obscure visceral symptoms. During these investigations it can happen that a liver lesion is discovered. This lesion, solid or cystic, when discovered in the liver of a healthy person, is called hepatic incidentaloma. This s...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Induction of transplant tolerance is a clinically desirable goal. To provide unbiased insight into transplant tolerance, we analyzed gene expression profiling in peripheral blood mononuclear cells from recipients of living-donor liver transplants (LDLTs) who had retained an immune tolerance with a well-functioning gra...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:We made clinical trials of en bloc extended radical mastectomy (EXT) of a new type in 118 patients from 1980 through 1985. A variety of conventional radical mastectomies (RDL) were also performed in 105 patients from 1973 through 1985. A multivariate analysis was performed of the results to compare EXT and RDL. The re...
journal_title：International surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:A consecutive series of 385 patients with intussusception treated between January 1, 1982 and December 31, 1987 was analysed. Male patients predominated over female by a ratio of 2.2:1. Seventy nine per cent of patients were under 12 months of age. There was no seasonal variation in the incidence of intussusception. R...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Totally implantable access ports (TIAPs) are generally used in oncology. Few studies have addressed complications associated with the insertion site. A total of 233 consecutive oncology patients were enrolled to receive TIAP inserts via internal jugular vein (IJV) or subclavian vein (SV). Data on clinicopathologic par...
journal_title：International surgery
pub_type： 杂志文章
doi：10.9738/INTSURG-D-13-00185.1
更新日期：2014-03-01 00:00:00
abstract：:The authors give a brief review of the pathologic anatomy, the incidence and distribution, the probable etiologic factors in the development of spondylolysis and spondylisthesis, and a description of the clinical syndrome of this abnormality. It is pointed out that there are two distinct parts to the clinical syndrome...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:To fit for internal fixation of unstable fractures of various parts of the curved pelvis, plates of different shapes and sizes were devised. The plates were used in 18 clinical cases. The late complications such as leg length inequality, pelvic obliquity and low back pain were effectively avoided. ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The aim of this study was to compare two preoperative staging procedures of non-small cell lung cancer (NSCLC): one using positron emission tomography (PET) and one using conventional imaging studies. Accuracy, effects on patient management, and costs were calculated. Four hundred thirteen consecutive patients with NS...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:In a group of 82 women with congenital or acquired uterine malformation (such as intrauterine adhesions or uterus myomatosus), cerclage was successfully performed according to the McDonald method. The percentage of term deliveries increased from 29.8% to 69.2% and the percentage of spontaneous abortions decreased from...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:NO is an important mediator in the generalized inflammatory response of the body during sepsis and septic shock. We investigated the possible effects of L-arginine and aminoguanidine on plasma NO levels and the interaction between NO levels and lung tissue damage and blood gases in sepsis. Fifty Wistar male rats were ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:Congenital defects presenting at an adult age are subject to diagnostic errors because of their relative rarity and often odd clinical presentation. We illustrate a 63-year-old male patient with multiple ileal carcinoid tumors along with a carcinoid tumor in Meckel's diverticulum. The Meckel's diverticulum is a congen...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:We have analyzed 196 cases of pyloroduodenal obstruction due to peptic ulcer disease. Obstruction occurred in 19% of peptic ulcer patients. Males predominated five to one over females. Diagnosis could usually be made on clinical grounds alone. Air contrast x-ray studies were better than conventional barium meal x-rays...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Nine primary intra-abdominal or retroperitoneal liposarcomas, of which eight were recurrent tumors, were surgically resected and enrolled in this study. Histopathological examination of primary tumors revealed that the number of well-differentiated, pleomorphic and myxoid type was two, four and three, respectively. In...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Tubal occlusion through a culdotomy incision offers a method of surgical sterilization acceptable to women in some countries where abdominal sterilization is not acceptable. This technic requires skilled gynecologic surgeons, who are a limited resource in many developing countries. On the other hand, gynecologic surge...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：:In an attempt to assess the different methods of treatment of tumors of the esophagus we contacted 170 surgeons (in 1975-1976). Seventy-six (45%) answered a questionnaire concerning the surgical management of esophageal tumors, the reasons for non operability and non resectability, the place of radiotherapy, the valid...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:This is a 1 year study on the use of a culdoscopic sterilization technique on 250 patients aged 25 or more with at least 4 children and at least 6 weeks Postpartum. Clinical examination was made to exclude tumors, infections, or endometriosis. The laparoscope was used for transvaginal female sterilization employing ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:A retrospective analysis of 88 ovarian tumours diagnosed over five years (1980-1984) in multi-racial Singaporean Oriental women revealed 70 (79%) epithelial tumours (ET), 17 (8%) sex cordstromal (SCS), six (7%) germ cell (GCT) and five (6%) secondary (metastatic) (SEC) cancers. The racial proportions and histological ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:This case history re-emphasizes the absolute necessity for all cases of leukokoria or opaque media, where a view of the fundus is impossible, to have preliminary "A" or "B" scan ultrasonography. In 1960 perhaps only two or three institutions had the high resolution "B" scan equipment at their disposal. Today at least ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:Tamoxifen (Nolvadex) has been in use for over 20 years and currently is probably the most prescribed anti-cancer medication in the world. It is an orally effective, synthetic, non-steroidal, estrogen antagonist and agonist agent. In studies and trials it has been shown to have only limited side effects. It has produce...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：:Pathological and clinical characteristics of thyroid carcinoma are reported. In 379 routine consecutive autopsies in which carcinoma was not suspected, serial sections of thyroid gland were histologically examined. Latent thyroid carcinoma was detected in 15.7% of the glands. Papillary adenocarcinoma comprised 76.3%, ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：:We operated on 138 patients for intestinal obstruction. The different causes are discussed and their pattern of occurrence is compared with that reported from England and other African countries. The 27.6% mortality rate was closely associated with the 28.2% incidence of gangrene. Factors which may lower this high mor...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical prac...
journal_title：International surgery
pub_type： 杂志文章,评审
doi：10.9738/INTSURG-D-13-00056.1
更新日期：2014-01-01 00:00:00
abstract：:Results of immediate reconstruction of the defects resulting from excision of cancer of the cheek, lower jaw, upper jaw and lip in 13 patients using temporal island, deltopectoral and cervicoacromial flaps have been described. The surgical techniques have been outlined. Previous radiotherapy is not a contraindication ...
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:The use of imaging techniques and their increasing sensitivity have resulted in increased detection of incidentalomas of the endocrine organs. The aim of our study was to review the currently used evaluation schemes and the outcomes of surgical and conservative management of adrenal incidentalomas at an Indian center....
journal_title：International surgery
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
