Abstract：
:We report the sequence of A/B.L1, a tightly linked pair of genes from the A and B chorion families in Bombyx mori. Comparison with the previously characterized A/B.L11 and A/B.L12 pairs from the same species reveals moderate sequence divergence, which is clearly nonuniform. Although the average divergence of A/B.L12 from the other two pairs is more than double that between A/B.L11 and A/B.L1, the ratio differs by more than 30-fold in different DNA regions. One domain of the A gene is highly divergent between A/B.L12 and A/B.L1 or A/B.L11, but essentially invariable in the latter two. In well-aligned DNA segments, nearly all mutated sites (111/112) show variants shared by two of the three sequences, in 42% of the cases between the more distantly related pairs (A/B.L12 and either A/B.L1 or A/B.L11). Eight of the variants shared by distantly related pairs are clustered within 51 bp, suggesting the possibility that they arose through sequence transfers between gene pairs, rather than being primitive or resulting from independent mutations. The short intergenic, putatively regulatory DNA of the developmentally middle A/B.L1 and A/B.L11 pairs resembles that of the late HcA/HcB pairs, particularly in patches that may correspond to cis-regulatory elements.
journal_name
J Mol Evoljournal_title
Journal of molecular evolutionauthors
Tsitilou SG,Kafatos FCdoi
10.1007/BF02602909subject
Has Abstractpub_date
1989-11-01 00:00:00pages
396-406issue
5eissn
0022-2844issn
1432-1432journal_volume
29pub_type
杂志文章abstract：:The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-gamma. Replacement of PSMB5 by LMP7 changes the profile o...
journal_title：Journal of molecular evolution
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
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journal_title：Journal of molecular evolution
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