Slide navigation patterns among pathologists with long experience of digital review.

Abstract:

AIMS:In order to develop efficient digital pathology workstations, we studied the navigation patterns of pathologists diagnosing whole-slide images. To gain a better understanding of these patterns, we built a conceptual model based on observations. We also determined whether or not new navigation patterns have emerged among pathologists with extensive digital experience. METHODS AND RESULTS:Five pathologists were asked to diagnose a set of four cases while thinking out loud. The navigation within the digital slides was recorded and divided into re-occurring navigation actions. The pathologists reused the same type of actions, but their occurrence differed. The most common action was a slow panning that followed an edge structure or covered an area systematically, which accounted for 30.2% of all actions and had a median duration of 7.2 s. Of all the actions, 49% were carried out within the navigation overview and 38% of the actions could not have been performed with a conventional microscope. CONCLUSIONS:The new navigation possibilities in the digital workstation were used to a large extent. The division of actions into different concepts can be used to find and prioritize between existing user interface designs as well as to understand the different navigation styles used by different pathologists.

journal_name

Histopathology

journal_title

Histopathology

authors

Molin J,Fjeld M,Mello-Thoms C,Lundström C

doi

10.1111/his.12629

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

185-92

issue

2

eissn

0309-0167

issn

1365-2559

journal_volume

67

pub_type

杂志文章
  • Prognostic indicators in WHO 2003 low-grade endometrial stromal sarcoma.

    abstract:AIMS:Endometrial stromal sarcoma (ESS) has traditionally been divided into low and high grade, but the World Health Organization (WHO, 2003) has changed the definition. Since 2003, many studies have used the old criteria, and few have focused on WHO 2003-defined ESS low grade (ESS-LG). The aim of this study was to inve...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2011.04115.x

    authors: Feng W,Hua K,Gudlaugsson E,Yu Y,Zhou X,Baak JP

    更新日期:2013-04-01 00:00:00

  • Gleason drift in the NIHR ProtecT study.

    abstract:AIMS:There is increasing evidence of Gleason score (GS) drift in prostatic core biopsies during the last two decades. The ProtecT study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate-specific antigen (PSA) level, perineural invasion, tumour length and age on GS. ...

    journal_title:Histopathology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/his.12549

    authors: Oxley J,Simpkin A,Goepel J,Varma M,Griffiths D,Grigor K,Mayer N,Warren A,Deshmukh N,Bhattarai S,Dormer J,Hounsome L,Adamczyk LA,Metcalfe C,Lane JA,Davis M,Donovan JL,Neal DE,Hamdy FC,Robinson MC,ProtecT Study Grou

    更新日期:2015-02-01 00:00:00

  • Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach.

    abstract:AIMS:To investigate the relation of fatty acid synthase (FAS) expression to the clinicopathological characteristics of gastric cancers and gastric tumorigenesis. METHODS AND RESULTS:FAS expression was examined immunohistochemically in 626 gastric cancers, 51 gastric adenomas, and non-neoplastic epithelium contiguous w...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2002.01289.x

    authors: Kusakabe T,Nashimoto A,Honma K,Suzuki T

    更新日期:2002-01-01 00:00:00

  • Mixed pulmonary blastoma and carcinosarcoma.

    abstract::Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1994.tb01574.x

    authors: Olenick SJ,Fan CC,Ryoo JW

    更新日期:1994-08-01 00:00:00

  • Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast.

    abstract:AIMS:Comedo carcinoma is generally regarded as the subtype of ductal carcinoma in situ (DCIS) most likely to progress to invasive carcinoma. Increased angiogenesis could be associated with an enhanced risk of progression and might therefore be a marker of poor prognosis, as can be demonstrated for invasive breast tumou...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2005.02299.x

    authors: Vogl G,Dietze O,Hauser-Kronberger C

    更新日期:2005-12-01 00:00:00

  • Tenascin-C in primary malignant melanoma of the skin.

    abstract:AIMS:To investigate the expression and the prognostic role of glycoprotein Tenascin-C (Tn-C) in primary melanoma of the skin. METHODS AND RESULTS:The immunohistochemical expression of Tn-C was studied in 98 primary melanomas and related to inflammation, invasion, and patient outcome. Patients were followed up for dise...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2004.01976.x

    authors: Ilmonen S,Jahkola T,Turunen JP,Muhonen T,Asko-Seljavaara S

    更新日期:2004-10-01 00:00:00

  • Dilated (congestive) cardiomyopathy: a syndrome of severe cardiac dysfunction with remarkably few morphological features of myocardial damage.

    abstract::A review of 76 endomyocardial biopsies and 54 autopsies of patients with dilated cardiomyopathy (DCM) revealed features of hypertrophy and degenerative changes associated with long-standing hypertrophy. Long-term survivors had significantly heavier heart weights. Short-term survivors had heavier than normal right vent...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1985.tb02821.x

    authors: Rose AG,Beck W

    更新日期:1985-04-01 00:00:00

  • Immunohistochemical expression patterns of AP2alpha and AP2gamma in the developing fetal human breast.

    abstract:AIMS:AP2alpha (TFAP2A) and AP2gamma (TFAP2G) transcription factors have been implicated in the control of proliferation, differentiation and apoptosis of normal breast epithelium and in breast cancer. The aim of this study was to provide a comprehensive analysis of the expression patterns of TFAP2A and TFAP2G in the de...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2007.02887.x

    authors: Friedrichs N,Steiner S,Buettner R,Knoepfle G

    更新日期:2007-12-01 00:00:00

  • Intestinal metaplasia subtyping: evaluation of Gomori's aldehyde fuchsin for routine diagnostic use.

    abstract:AIMS:Intestinal metaplasia (IM) has been implicated in the pathogenesis of gastro-oesophageal carcinoma, but because of its common occurrence, its specificity for use in cancer surveillance is low. IM subtypes characterized by mucin phenotype have been studied to try and improve specificity. METHODS AND RESULTS:On bal...

    journal_title:Histopathology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2559.1997.2110847.x

    authors: Shah KA,Deacon AJ,Dunscombe P,Price AB

    更新日期:1997-09-01 00:00:00

  • Pathology of the gastric antrum and body associated with Helicobacter pylori infection in non-ulcerous patients: is the bacterium a promoter of intestinal metaplasia?

    abstract::A series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for Helicobacter pylori (H. pylori) colonization in the gastric antral and/or body mucosa using Giemsa staining. Findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1993.tb00062.x

    authors: Rugge M,Di Mario F,Cassaro M,Baffa R,Farinati F,Rubio J Jr,Ninfo V

    更新日期:1993-01-01 00:00:00

  • Splenic marginal zone atrophy and progressive CD8+ T-cell lymphocytosis in HIV infection: a study of adult post-mortem spleens from Côte d'Ivoire.

    abstract:AIMS:Progressive changes have been reported in lymph nodes in HIV infection, but few accounts describe altered splenic histology at different stages of the disease. Investigation of splenic changes accompanying the progressive CD4+ T-cell depletion that occurs in HIV infection could shed light on normal immunological i...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01569.x

    authors: Wilkins BS,Davis Z,Lucas SB,Delsol G,Jones DB

    更新日期:2003-02-01 00:00:00

  • Pigmented spindle cell carcinoid tumour of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms.

    abstract:AIMS:A variety of histological variants of thymic carcinoid tumour have been described. A rare case of pigmented spindle cell carcinoid tumour of the thymus is documented and compared with the reported cases of thymic pigmented carcinoid tumour in the literature, with a discussion of the differential diagnosis of spind...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2002.01339.x

    authors: Kuo TT

    更新日期:2002-02-01 00:00:00

  • A histological comparison of cutaneous malignant melanoma between the Oxford Region and Western Australia.

    abstract::Two series of cutaneous malignant melanoma (CMM), one from a low incidence area (the Oxford Region) and one from a high incidence area (Western Australia), were compared by one pathologist using the same histological criteria. The findings included similarities in the distributions of histogenetic type of CMM, predomi...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1982.tb02765.x

    authors: Heenan PJ,Holman CD

    更新日期:1982-11-01 00:00:00

  • Neurofilament is superior to cytokeratin 20 in supporting cutaneous origin for neuroendocrine carcinoma.

    abstract:AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.13758

    authors: Stanoszek LM,Chan MP,Palanisamy N,Carskadon S,Siddiqui J,Patel RM,Harms KL,Lowe L,Fullen DR,Harms PW

    更新日期:2019-02-01 00:00:00

  • CD 30-positive transformed follicular lymphoma: two case reports and literature review.

    abstract:AIMS:Here we report two cases of follicular lymphoma that transformed to CD30 positive diffuse large B cell lymphoma and review the literature on this topic. RESULTS:The first case represents an example of early transformation of conventional low-grade follicular lymphoma to CD30-positive large B cell lymphoma. Immuno...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/his.12733

    authors: Montes-Moreno S,Climent F,González de Villambrosía S,González Barca EM,Batlle A,Insunza A,Pané-Foix M,Colorado M,Martin-Sánchez G,Espiga CR,Conde E,Piris MA

    更新日期:2015-12-01 00:00:00

  • Keratin 10-positive orthokeratotic dysplasia: a new leucoplakia-type precancerous entity of the oral mucosa.

    abstract:AIMS:We investigated a group of oral mucosal lesions with characteristic hyperorthokeratotic foci, which we termed orthokeratotic dysplasia (OKD), to determine if it could be identified as a distinct histopathological entity. METHODS AND RESULTS:We screened 282 surgical specimens from 200 patients with oral leucoplaki...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2012.04283.x

    authors: Kobayashi T,Maruyama S,Abé T,Cheng J,Takagi R,Saito C,Saku T

    更新日期:2012-11-01 00:00:00

  • Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma.

    abstract:AIMS:This study has compared the tissue expression of the p53 tumour suppressor protein and DNA repair proteins APE1, hMSH2 and ERCC1 in normal, dysplastic and malignant lip epithelium. METHODS AND RESULTS:Morphological analysis and immunohistochemistry were performed on archived specimens of normal lip mucosa (n=15),...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2011.03756.x

    authors: Souza LR,Fonseca-Silva T,Pereira CS,Santos EP,Lima LC,Carvalho HA,Gomez RS,Guimarães AL,De Paula AM

    更新日期:2011-02-01 00:00:00

  • 'Pseudomesotheliomatous' carcinomas of the pleura: a 10-year analysis of cases from the Environmental Lung Disease Research Group, Cardiff.

    abstract:AIMS:To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma. METHODS AND RESULTS:Over a 10-year (1990-2000) study period 53 carcinomas mimicking diffuse pleural mesothelioma ('pseudomesotheliomatous' carc...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.2003.01674.x

    authors: Attanoos RL,Gibbs AR

    更新日期:2003-11-01 00:00:00

  • Glandular lesions of the uterine cervix: the present state of our knowledge.

    abstract::The assessment of squamous lesions of the uterine cervix is a major preoccupation of diagnostic histopathologists and this can overshadow the recognition of significant abnormalities affecting the adjacent endocervical glands. This review gives an account of recent advances in our knowledge of the histology and histoc...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1986.tb02578.x

    authors: Wells M,Brown LJ

    更新日期:1986-08-01 00:00:00

  • A fixation-decalcification procedure for bone biopsies.

    abstract::A procedure for the simultaneous fixation and decalcification of bone biopsies is described. Mild acidic fixatives (such as Bouin's fluid) are effective decalcifying agents when made calcium-free by a continuous circulation through a column of anion-binding ion exchange resin. The procedure has been found relatively f...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1978.tb01725.x

    authors: Bussolati G

    更新日期:1978-09-01 00:00:00

  • Immunohistochemical study of endometrial high-grade endometrioid carcinoma with or without a concurrent low-grade component: implications for pathogenetic and survival differences.

    abstract:AIMS:To compare the clinical and pathogenetic differences between high-grade (HG) endometrioid carcinomas with and without concurrent low-grade (LG) components. METHODS AND RESULTS:The expression of ARID1A, PTEN, p53 and mismatch repair (MMR) proteins in HG endometrioid carcinomas without (n = 19) or with (n = 22) con...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/his.12664

    authors: Mao TL,Ayhan A,Kuo KT,Lin MC,Tseng LH,Ogawa H

    更新日期:2015-10-01 00:00:00

  • Atypical and malignant meningiomas: importance of micronecrosis as a prognostic indicator.

    abstract::Twenty-eight patients with a diagnosis of either atypical or malignant meningioma, according to the World Health Organisation (WHO) classification, were followed up to relate histopathological features with times to recurrence and death. Five year disease-free survival was 41% with a median disease free survival of 27...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1993.tb01218.x

    authors: McLean CA,Jolley D,Cukier E,Giles G,Gonzales MF

    更新日期:1993-10-01 00:00:00

  • Metastasis in pleural mesothelioma. Immunohistochemical markers for disseminated disease.

    abstract:AIMS:To examine 13 cases of mesothelioma with metastases and compare these with 29 biopsy samples of patients without metastases. Metastatic disease was defined as tumour in which tumour appeared in a different cavity/tissue of the body and which showed no direct spread. Consequently, mediastinal nodal and parenchymal ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2004.01844.x

    authors: Lumb PD,Suvarna SK

    更新日期:2004-04-01 00:00:00

  • A study of Gleason score interpretation in different groups of UK pathologists; techniques for improving reproducibility.

    abstract:AIMS:To test the effectiveness of a teaching resource (a decision tree with diagnostic criteria based on published literature) in improving the proficiency of Gleason grading of prostatic cancer by general pathologists. METHODS:A decision tree with diagnostic criteria was developed by a panel of urological pathologist...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2006.02394.x

    authors: Griffiths DF,Melia J,McWilliam LJ,Ball RY,Grigor K,Harnden P,Jarmulowicz M,Montironi R,Moseley R,Waller M,Moss S,Parkinson MC

    更新日期:2006-05-01 00:00:00

  • Possible liver cell differentiation in testicular germ cell tumours.

    abstract::Germ cell tumours may imitate various structures of the developing embryo and foetus. Certain structures have, however, very rarely or never been observed in these tumours. Thus the presence of hepatic tissue in testicular germ cell tumours has not been reported. In a series of 37 non-seminomatous testicular tumours s...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1983.tb02266.x

    authors: Jacobsen GK,Jacobsen M

    更新日期:1983-07-01 00:00:00

  • Aggressive B-cell lymphomas: a review based on the workshop of the XI Meeting of the European Association for Haematopathology.

    abstract::The generic term aggressive B-cell lymphoma includes a variety of entities, each with particular diagnostic and therapeutic issues. To define these entities better and to help confront such issues, a workshop was organized by the European Association of Haematopathology (EAHP) and the Society of Haematology during the...

    journal_title:Histopathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2559.2005.02068.x

    authors: Leoncini L,Delsol G,Gascoyne RD,Harris NL,Pileri SA,Piris MA,Stein H

    更新日期:2005-03-01 00:00:00

  • Histological grading of invasive breast carcinoma--a simplification of existing methods in a large conservation series with long-term follow-up.

    abstract:AIMS:To assess the validity of grading in the Edinburgh Breast Conservation Series; a consecutive cohort of 1812 early breast cancer patients treated by breast conservation and radiotherapy between 1981 and 1998 in a single specialist centre with > or =9 years' follow-up and full staging data. METHODS AND RESULTS:A si...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2009.03429.x

    authors: Thomas JS,Kerr GR,Jack WJ,Campbell F,McKay L,Pedersen HC,Kunkler IH,Cameron DA,Chetty U,Bartlett JM

    更新日期:2009-12-01 00:00:00

  • Microvessel density for melanoma prognosis.

    abstract:AIMS:Two-hundred and four accessible cases of malignant melanoma from the Grampian region of Scotland, collected over a period of 4 years, were studied for standard prognostic indicators for comparison with microvessel density. METHODS AND RESULTS:The range of tumour thickness varied from in-situ melanoma to 14.8 mm. ...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.2005.02193.x

    authors: Depasquale I,Thompson WD

    更新日期:2005-08-01 00:00:00

  • Inflammatory aetiology of primary oesophageal achalasia: an immunohistochemical and ultrastructural study of Auerbach's plexus.

    abstract:AIM:Achalasia is a disease of the oesophagus characterized by increased lower oesophageal sphincter (LOS) tone, absence of LOS relaxation with swallowing and aperistalsis of the body of the oesophagus. The aetiology and pathogenesis of idiopathic achalasia is still controversial. METHODS AND RESULTS:We examined 16 oes...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2559.1999.035005445.x

    authors: Raymond L,Lach B,Shamji FM

    更新日期:1999-11-01 00:00:00

  • Is poor prognosis really related to HLA-DR expression by malignant melanoma cells?

    abstract::HLA-DR expression was examined in 50 consecutive primary cutaneous malignant melanomas with a Breslow depth greater than 2 mm using two well-characterized monoclonal antibodies which detect fixation-resistant epitopes. In 31 of these cases (62%) a subpopulation of tumour cells was reactive, although there was consider...

    journal_title:Histopathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2559.1992.tb01011.x

    authors: Colloby PS,West KP,Fletcher A

    更新日期:1992-05-01 00:00:00