Abstract:
:To identify histological preneoplastic lesions and early neoplastic foci, a histological and immunohistochemical study has been conducted on a series of 18 cases with the rare association of multiple intraductal papillomas and in situ breast carcinoma. The pathological and clinical data of these cases have been collated. A close anatomical and spatial association between the benign papillomas and areas of in situ carcinoma (mostly of the cribriform type) was a frequent finding. In agreement with the results of our previous investigations, cytoplasmic CEA has been found to be a marker of intraductal carcinomas, while staining for actin has been found useful to identify the myoepithelial cells present in benign papillomas as opposed to carcinomas. The immunohistochemical procedures for these two markers have been conducted on parallel sections; alternatively, an immunoperoxidase/immuno-galactosidase sequence has been applied on the same section. The results indicate that, in cases with multiple papillomas, CEA-positive, myoepithelial cell-free carcinomatous areas can be anatomically associated with and even present inside the benign-looking papillary lesions. These findings can be interpreted as evidence of a malignant transformation of intraductal papillomas, or, less likely, of their 'cancerization' by ductal carcinoma.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Papotti M,Gugliotta P,Ghiringhello B,Bussolati Gdoi
10.1111/j.1365-2559.1984.tb02414.xsubject
Has Abstractpub_date
1984-11-01 00:00:00pages
963-75issue
6eissn
0309-0167issn
1365-2559journal_volume
8pub_type
杂志文章相关文献
HISTOPATHOLOGY文献大全abstract::In an ultrastructural study of oral lesions in lichen planus, it was found that some plasma cells have an associated lamina densa. Subsequently, similar appearances have been found in pemphigus vulgaris, in the inflammatory cell infiltrates in dental granulomas and cysts and in a patient with Ehlers-Danlos syndrome. T...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1979.tb03010.x
更新日期:1979-07-01 00:00:00
abstract:AIMS:To evaluate whether a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in bone marrow trephine biopsies (BMBs) of primary myelofibrosis (PMF) patients may have prognostic implications. METHODS AND RESULTS:Reticulin fibrosis, collagen deposition and osteosclerosis...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13309
更新日期:2017-12-01 00:00:00
abstract:AIMS:Perineural invasion (PNI) by prostatic adenocarcinoma is debated as a prognostic parameter. This study investigates the prognostic predictive value of PNI in a series of patients with locally advanced prostate cancer treated with radiotherapy and androgen deprivation using 10 years outcome data from the TROG 03.04...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14107
更新日期:2020-08-01 00:00:00
abstract:AIM:Dual-colour chromogenic in-situ hybridization (dc-CISH) is an emerging methodology for characterizing genomic alterations. This study was aimed at evaluating the performance of a dc-CISH kit (ZytoVision) in determining human epidermal growth factor receptor 2 (HER2) status in breast cancer. METHODS AND RESULTS:Two...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2011.04037.x
更新日期:2011-11-01 00:00:00
abstract::The light microscopical appearance of the normal parathyroid gland based on an autopsy study of 138 glands from 38 adults without evidence of hyperparathyroidism, is described. It differs from earlier descriptions in that we found less adipose tissue in the glands of many normal adults than had been reported. This obs...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1984.tb02353.x
更新日期:1984-05-01 00:00:00
abstract:AIM:Primary cutaneous neuroendocrine carcinoma, or Merkel cell carcinoma (MCC), cannot be distinguished morphologically from small-cell neuroendocrine carcinomas (SmCC) from other sites. Immunohistochemistry is required to confirm cutaneous origin, and is also used for detection of sentinel lymph node (SLN) metastases ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13758
更新日期:2019-02-01 00:00:00
abstract:AIMS:To assess cytokeratin (CK) and thyroid transcription factor (TTF)-1 expression in primary epithelial lung tumours by comparison with non-pulmonary carcinomas and to correlate it with their histological type and grade. METHODS AND RESULTS:Immunohistochemistry using antibodies against CKs 5/6, 7, 19, 20 and TTF-1 w...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2004.01893.x
更新日期:2004-08-01 00:00:00
abstract:AIMS:Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosar...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2001.01277.x
更新日期:2001-11-01 00:00:00
abstract:AIMS:Pathological or neuroprotective mechanisms in the brain in severe malaria may arise from microvascular obstruction with malaria-parasitized erythrocytes. This study aimed to investigate the role of hypoxia and induction of the vascular endothelial growth factor (VEGF) pathway in the neuropathophysiology of severe ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2010.03619.x
更新日期:2010-08-01 00:00:00
abstract::High levels of bcl-2 protein have been found in a wide variety of human cancers. Since p53 gene inactivation occurs in over half of human cancers, it is possible that loss of p53-mediated repression of bcl-2 gene expression accounts, at least in part, for the frequent abnormalities in bcl-2 protein production seen in ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-431.x
更新日期:1996-04-01 00:00:00
abstract:AIMS:Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histol...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14114
更新日期:2020-08-01 00:00:00
abstract::In the Cambridge renal transplant unit percutaneous needle biopsies of renal transplants have been extensively used to help identify the cause of impaired allograft function. During the period 1966--1973, 154 of the 269 renal allografts transplanted were biopsied at least once during the first 90 days after transplant...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1977.tb01656.x
更新日期:1977-05-01 00:00:00
abstract:AIMS:Fibroadenomas (FAs) and phyllodes tumours (PTs) are fibroepithelial tumours. Mutations in MED12 exon 2 have been reported in FAs. This study investigated the MED12 mutations in a spectrum of fibroepithelial tumours. METHODS AND RESULTS:Using direct sequencing, we analysed MED12 exon 2 mutations on 121 samples, in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.12764
更新日期:2016-02-01 00:00:00
abstract::Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.13380
更新日期:2018-01-01 00:00:00
abstract:AIMS:There have been several cell kinetic studies of thymoma, but the effectiveness of using Ki67 antibody as a tool to measure proliferative activity in this tumour was rarely evaluated. We carried out an immuno-histochemical study using this antibody to assess the clinicopathological correlation and the prognostic si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00504.x
更新日期:1998-11-01 00:00:00
abstract:AIMS:Biliary intraductal tubular neoplasms that are non-mucinous and negative for mucin 5AC (MUC5AC) are called intraductal tubulopapillary neoplasms (ITPNs). Intraductal tubular neoplasms with mucinous cytoplasm and MUC5AC positivity also occur and their nature remains unclear, although some pathologists may classify ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14103
更新日期:2020-06-01 00:00:00
abstract:AIMS:Three cases with features of so-called 'Warthin-like tumour' of the thyroid (WaLTT) are described, in order to evaluate its relationship with papillary carcinoma (PC). METHODS AND RESULTS:We performed an histological and immunohistochemical study with emphasis on RET/PTC expression. The most striking features are...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00925.x
更新日期:2000-06-01 00:00:00
abstract:AIMS:Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic int...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2008.03092.x
更新日期:2008-08-01 00:00:00
abstract:AIMS:Pulmonary fibrosis in acute and chronic lung disease has been much investigated, but little attention has been directed at the elastic tissue in these situations. Our aim was to verify whether elastic deposition accompanies collagen deposition in the repairing process of acute and chronic lung injury. METHODS AND...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00992.x
更新日期:2000-11-01 00:00:00
abstract::The use of percutaneous renal tumour biopsy (RTB) as a diagnostic tool for the histological characterization of renal masses has increased dramatically within the last 30 years. This increased utilization has paralleled advances in imaging techniques and an evolving knowledge of the clinical value of nephron sparing s...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/his.12495
更新日期:2014-09-01 00:00:00
abstract:AIMS:To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs). METHODS AND RESULTS:Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7,...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2006.02444.x
更新日期:2006-06-01 00:00:00
abstract:AIMS:The clinicopathological distinctiveness of nodal cytotoxic molecule (CM)-positive Epstein-Barr virus (EBV)-associated peripheral T cell lymphoma (PTCL) remains to be clarified. We investigated 26 patients with this lymphoma compared to nodal CM(+) EBV(-) PTCL (n = 39) and extranasal natural killer/T cell lymphoma ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2012.04199.x
更新日期:2012-08-01 00:00:00
abstract::A retrospective histopathological study was undertaken to determine the prevalence of mucin filled ducts and their associated mucinous proliferation in 962 breast cancers and 335 benign lesions. A total of 38 (3%) cases with mucin filled ducts was identified and 27 (2%) of these showed mucin extravasation into the adj...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1996.d01-535.x
更新日期:1996-12-01 00:00:00
abstract:AIMS:In T cells, protein kinase C (PKC) theta plays a major role in T-cell receptor (TCR)-mediated activation of a novel nuclear factor (NF)-kappaB pathway that involves phosphorylation of p65 at serine 536 (Pp65(Ser536)). Bcl-10 acts along the same pathway downstream of PKC theta to activate NF-kappaB. The aim was to ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.2009.03250.x
更新日期:2009-03-01 00:00:00
abstract:AIMS:Colorectal carcinoma (CRC) with micropapillary (MP) features has only been described recently and is still being characterized. METHODS AND RESULTS:We reviewed the clinicopathological and molecular features of 42 CRC with MP features. Twenty-nine cases were also evaluated for immunohistochemical evidence of epith...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.13068
更新日期:2017-01-01 00:00:00
abstract::Thirty-two cases of mucoepidermoid carcinoma of the salivary glands were studied in order to characterize the expression of simple mucin-type carbohydrate antigens T, Tn and sialosyl-Tn and to evaluate its implication for tumour histogenesis. Monoclonal antibodies of known specificity were used on formalin-fixed, para...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01372.x
更新日期:1994-12-01 00:00:00
abstract::Clinicopathological and immunohistological features of three cases of large cell lymphoma of bone are reported. On histological grounds, all the cases were diagnosed as histiocytic lymphomas (Rappaport) or primary centroblastic lymphomas, polymorphic subtype (Kiel). On immunophenotyping, malignant cells strongly react...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1988.tb01928.x
更新日期:1988-02-01 00:00:00
abstract::The recognition of recurrent genetic alterations in specific tumour types has provided the basis for the reclassification of certain soft tissue neoplasms, and molecular analysis of patient material has the potential to provide both diagnostic and prognostic information. In this review, we evaluate the role of molecul...
journal_title:Histopathology
pub_type: 历史文章,杂志文章,评审
doi:10.1046/j.1365-2559.2000.01107.x
更新日期:2000-12-01 00:00:00
abstract::In view of the critical role of dendritic cells in immune mediated skin diseases, we have investigated the membrane antigen patterns and ultrastructure of cutaneous dendritic cells in eight patients with chronic discoid lupus erythematosus and five with subacute cutaneous lupus erythematosus. In the lesional epidermis...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00531.x
更新日期:1994-04-01 00:00:00
abstract:AIMS:MYC is a proto-oncogene that is frequently dysregulated in various malignancies, through translocation or amplification. Radiation-associated angiosarcoma frequently shows MYC amplification, and immunohistochemical expression has been shown to be a reliable surrogate marker for amplification, but less is known abo...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/his.14168
更新日期:2020-10-01 00:00:00