当前位置： SCI文献检索 > Human Vaccines & Immunotherapeutics期刊下所有文献 > Potential effect of PCV13 introduction on Emergency Department accesses for lower respiratory tract infections in elderly and at risk adults.

Potential effect of PCV13 introduction on Emergency Department accesses for lower respiratory tract infections in elderly and at risk adults.

Abstract：

:Liguria, an administrative region in northern Italy characterized by a decade of high PCV coverage in paediatric age group, has issued new PCV13 recommendations for free active immunization in adults with risk factors and subjects aged ≥ 70 years old. Main aims of this study are: (1) a descriptive epidemiology of the clinical burden of lower respiratory tract infections (LRTI) in adults ≥18 years of age; and (2) a crossover evaluation of the effect of introduction of PCV13 vaccination in adults aged ≥70 years old, in terms of ED accesses for LRTI, obtained by a Syndrome Surveillance System (SSS). The ED access, chief complaint based SSS will allow an active surveillance of a population cohort of >430 000 individuals resident in Genoa metropolitan area, aged ≥18 years old, for a period of 60 months. During pre-PCV period, annual cumulative incidence of ED accesses for LRTI was equal to 7/1000 and 2% in ≥65 and ≥85 year adults, respectively. In ≥65 years adults, more than 70% of subjects identified by the SSS has at least one risk condition, with a peak of 87% in ≥85 year cohort. New Ligurian PCV13 recommendations can potentially reach more than 75% of ED accesses for LRTI. Data highlights the heavy impact of LRTI in terms of ED accesses, especially in the elderly and subjects with chronic conditions and the usefulness of SSS tool for monitoring PCV vaccination effect.

journal_name

Hum Vaccin Immunother

journal_title

Human vaccines & immunotherapeutics

authors

Ansaldi F,Orsi A,Trucchi C,De Florentiis D,Ceravolo A,Coppelli M,Schiaffino S,Turello V,Rosselli R,Carloni R,Icardi G,Study Group LP,Canepa P,Sticchi L,Zanetti R,Cremonesi I,Brasesco P,Moscatelli P

doi

10.4161/hv.34419

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

166-71

issue

1

eissn

2164-5515

issn

2164-554X

journal_volume

11

pub_type

杂志文章

相关文献

Human Vaccines & Immunotherapeutics文献大全
  • Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.

    abstract：:Different strategies have been proposed for the development of protein subunit vaccine candidates for tuberculosis (TB), which shows better safety than other types of candidates and the currently used Bacillus Calmette-Guérin (BCG) vaccine. In order to develop more effective protein subunits depending on the mechanism...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2015.1037057

    authors： Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

    更新日期：2015-01-01 00:00:00

  • Parents' attitude toward multiple vaccinations at a single visit with alternative delivery methods.

    abstract：:Last decades, the number of routine childhood vaccinations has increased considerably, which consequently has led to multiple vaccine injections per consultation. Implementation of additional vaccines will probably lead to more than 2 vaccine injections per consult, which might be a barrier for parents to vaccinate th...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.29361

    authors： Kaaijk P,Kleijne DE,Knol MJ,Harmsen IA,Ophorst OJ,Rots NY

    更新日期：2014-01-01 00:00:00

  • Acute gastroenteritis hospitalizations among children aged < 5 years before and after introduction of rotavirus vaccines: a hospital-based surveillance study in Galicia, Spain.

    abstract：:Rotavirus vaccines were licensed in Spain between late 2006 and early 2007. Rotavirus vaccination was recommended but not reimbursed by the Spanish National Health System. Significant coverage rates have been reached in Galicia, with an average of 47% since the period July 2007-June 2008. We aim to explore eventual va...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.20178

    authors： Martinón-Torres F,Martinón-Torres N,Bouzón Alejandro M,Redondo Collazo L,Pértega-Díaz S,Seoane-Pillado MT,Aboal Viñas J,San-Martín M

    更新日期：2012-07-01 00:00:00

  • In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate.

    abstract：:Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaraldehyde catalyzed cross-linked α-poly-L-lysine and CRM197 protein matr...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2019.1599674

    authors： Griffin TJ 4th,Thanawastien A,Cartee RT,Mekalanos JJ,Killeen KP

    更新日期：2019-01-01 00:00:00

  • A phase 1, randomized, open-label, active-controlled trial to assess the safety of a meningococcal serogroup B bivalent rLP2086 vaccine in healthy adults.

    abstract：:Neisseria meningitidis serogroup B (MnB) is a significant cause of invasive meningococcal disease, but no broadly protective vaccine is yet approved. We assessed the safety and immunogenicity of a bivalent MnB vaccine composed of lipidated subfamily A and B variants of recombinant LP2086 (rLP2086, also known as factor...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.4161/hv.19983

    authors： Sheldon EA,Schwartz H,Jiang Q,Giardina PC,Perez JL

    更新日期：2012-07-01 00:00:00

  • Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season.

    abstract：:One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2019.1688040

    authors： Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

    更新日期：2020-06-02 00:00:00

  • Immunogenicity of different dosing schedules of the human live attenuate rotavirus vaccine (RV1) in infants and children: a meta-analysis.

    abstract：:Rotavirus immunization strategies have become part of a comprehensive global public health program to control rotavirus-associated gastroenteritis, particularly in infants and children in developing countries. Several studies have reported the efficacy of different rotavirus vaccine dosing schedules, but with mixed fi...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1080/21645515.2018.1537742

    authors： Dai X,Bai R,Jian M,Ji Z,Ding Z,Wang F,Bi Y,Manzamaesso A,Chen T,Luo L,Liu A,Bao F

    更新日期：2019-01-01 00:00:00

  • The regulatory T cells in anti-influenza antibody response post influenza vaccination.

    abstract：:The efficacy and effectiveness of influenza vaccines depend primarily on the vaccine recipient and the virus similarity to the endemic virus. Regulatory T cells (Tregs) and cytokines are known to restrict immune responses against viral infections. We conducted this study to explore the role of Tregs, cytokines, and an...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 临床试验,杂志文章

    doi：10.4161/hv.21117

    authors： Wang SM,Tsai MH,Lei HY,Wang JR,Liu CC

    更新日期：2012-09-01 00:00:00

  • Meningococcal vaccine: a new vaccine to combat meningococcal disease in India.

    abstract：:Meningococcal meningitis is caused by Neisseria meningitidis, a gram-negative, aerobic, encapsulated diplococcus. Meningococci are divided into numerous serogroups based on the composition of their capsular polysaccharide (Ps) antigens. At least 13 serogroups have been described: A, B, C, D, 29E, H, I, K, L, W-135, X,...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.4161/hv.21666

    authors： Verma R,Khanna P

    更新日期：2012-12-01 00:00:00

  • Novel dendritic cell-based vaccination in late stage melanoma.

    abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play an important role in stimulating an immune response of both CD4(+) T helper cells and CD8(+) cytotoxic T lymphocytes (CTLs). As such, DCs have been studied extensively in cancer immunotherapy for their capability to induce a specific anti...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.4161/hv.29110

    authors： Schneble EJ,Yu X,Wagner TE,Peoples GE

    更新日期：2014-01-01 00:00:00

  • HPV vaccine hesitancy among parents in Italy: a cross-sectional study.

    abstract：:This cross-sectional survey determined the vaccine hesitancy related to Human papillomavirus (HPV) and the determinants among parents of adolescents aged 12 and 13 years in Italy. Data was collected through a self-administered questionnaire. Two-thirds of the parents (66.7%) had heard of HPV infection and knew that th...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2020.1744367

    authors： Della Polla G,Pelullo CP,Napolitano F,Angelillo IF

    更新日期：2020-11-01 00:00:00

  • Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3.

    abstract：:Cancer progression depends on stepwise accumulation of oncogenic mutations and a select group of growth factors essential for tumor growth, metastasis and angiogenesis. Agents blocking the epidermal growth factor receptor (EGFR, also called HER1 and ERBB1) and the co-receptor called HER2/ERBB2 have been approved over ...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.1080/21645515.2015.1102809

    authors： Gaborit N,Lindzen M,Yarden Y

    更新日期：2016-03-03 00:00:00

  • Titering of 2009 pandemic H1N1 influenza virus hemagglutinin inhibition antibody in nonvaccinated pregnant women in Shiraz, Southern Iran.

    abstract：:Influenza may cause severe complications for pregnant women. In this study antibody response against 2009 H1N1 influenza virus in pregnant women was investigated. This seroprevalance cross sectional and questionnaire based study was conducted using a convenient sampling method. Blood samples of pregnant women were che...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.19189

    authors： Honarvar B,Moghadami M,Moattari A,Emami A,Tabatabaee HR,Jahromi BN,Asadi N,Mousavizadeh A,Lankarani KB,Joulaei H,Ghaffarpasand F

    更新日期：2012-05-01 00:00:00

  • Q fever vaccination: Australian animal science and veterinary students' One Health perspectives on Q fever prevention.

    abstract：:Unvaccinated animal science and veterinary students are at risk of Q fever, a vaccine-preventable zoonotic disease transmitted from animals to humans. We investigated students' perspectives on Q fever prevention using a One Health approach combining animal, human and environmental health. Animal science and veterinary...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2020.1829900

    authors： Rahaman MR,Milazzo A,Marshall H,Chaber AL,Bi P

    更新日期：2020-11-12 00:00:00

  • Recommending immunizations to adolescents in Turkey: a study of the knowledge, attitude, and practices of physicians.

    abstract：:Introduction: The aim of this study was to determine the knowledge, attitudes, and practices of family physicians and pediatricians in regard to adolescent immunization.Methods: The study was conducted from March to May 2017. A total of 665 physicians participated. Participants were asked 31 questions about their pers...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2020.1715146

    authors： Kara Elitok G,Bulbul L,Altuntas SB,Altuntas B,Günindi G,Haltaş M,Yuvarlan A,Toprak D,Bulbul A

    更新日期：2020-05-03 00:00:00

  • Preparation and evaluation of immunogenic conjugates of Salmonella enterica serovar Typhi O-specific polysaccharides with diphtheria toxoid.

    abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a major health problem particularly in developing countries. The available vaccines have certain limitations regarding their efficacy, and inability to induce an immune response especially in individuals under 2 years of age. Conjugate vaccines ...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.18350

    authors： Ali A,An SJ,Cui C,Haque A,Carbis R

    更新日期：2012-02-01 00:00:00

  • Regional variations in HPV vaccination among 9-17 year old adolescent females from the BRFSS, 2008-2010.

    abstract：:Human papillomavirus (HPV) vaccine uptake among 18-26 y old women varies by geographic region in the US. However, little is known about regional variations in vaccination among girls who are in the vaccine's targeted age groups. Regional variation in HPV vaccination among female adolescents (9-17 y old) was examined u...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/21645515.2014.980202

    authors： Hirth JM,Rahman M,Smith JS,Berenson AB

    更新日期：2014-01-01 00:00:00

  • Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.

    abstract：:Attenuated measles virus (MV) is one of the most effective and safe vaccines available, making it attractive candidate vector to prevent infectious diseases. Attenuated MV have acquired the ability to use the complement regulator CD46 as a major receptor to mediate virus entry and intercellular fusion. Therefore, atte...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.1080/21645515.2015.1122146

    authors： Baldo A,Galanis E,Tangy F,Herman P

    更新日期：2016-05-03 00:00:00

  • Plasmodium falciparum gametocyte transit through the cutaneous microvasculature: A new target for malaria transmission blocking vaccines?

    abstract：:Malaria remains one of the most significant infectious diseases worldwide. Concordant with scaled intervention efforts and the emphasis of elimination and eradication on the agenda of many malaria control programs, the development of a malaria vaccine that reduces transmission of the parasite from human host to mosqui...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.1080/21645515.2016.1183076

    authors： Nixon CP

    更新日期：2016-12-01 00:00:00

  • On-label and off-label use of high-dose influenza vaccine in the United States, 2010-2012.

    abstract：:High-dose inactivated, influenza vaccine was licensed by the FDA in December 2009 for adults aged 65 y and older. The ACIP did not issue or state a preference for a specific vaccine in the elderly population. The extent of its on-label and off-label use is unknown. Using the MarketScan Commercial Claims and Encounters...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2015.1011026

    authors： McGrath LJ,Brookhart MA

    更新日期：2015-01-01 00:00:00

  • Hepatitis B-related knowledge and vaccination in association with discrimination against Hepatitis B in rural China.

    abstract：:Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2015.1069932

    authors： Yu L,Wang J,Zhu D,Leng A,Wangen KR

    更新日期：2016-01-01 00:00:00

  • Acceptance of varicella vaccination.

    abstract：:Varicella is a common vaccine-preventable disease that usually presents in children as a mild infection; however, severe complications also occur. The burden of varicella is significant in the terms of incidence, complication, and hospitalization rate related to varicella and economic disease burden. Despite the evide...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2020.1843337

    authors： Horváth A

    更新日期：2020-12-16 00:00:00

  • The 100 top-cited studies on vaccine: a bibliometric analysis.

    abstract：:Objective: The objective of this study was to analyze the 100 most cited studies on vaccine.Methods: A comprehensive search of studies on vaccine was performed in the Web of Science Core Collection without year or language restrictions. The 100 top-cited studies were retrieved after screening abstracts or full-texts. ...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.1080/21645515.2019.1614398

    authors： Zhang Y,Quan L,Xiao B,Du L

    更新日期：2019-01-01 00:00:00

  • Efficacy of Mycobacterium vaccae immunotherapy for patients with tuberculosis: A systematic review and meta-analysis.

    abstract：:Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until Novem...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,meta分析,评审

    doi：10.1080/21645515.2017.1335374

    authors： Huang CY,Hsieh WY

    更新日期：2017-09-02 00:00:00

  • Two-year antibody persistence in children vaccinated at 12-15 months with a measles-mumps-rubella virus vaccine without human serum albumin.

    abstract：:One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1080/21645515.2017.1309486

    authors： Berry AA,Abu-Elyazeed R,Diaz-Perez C,Mufson MA,Harrison CJ,Leonardi M,Twiggs JD,Peltier C,Grogg S,Carbayo A,Shapiro S,Povey M,Baccarini C,Innis BL,Henry O

    更新日期：2017-07-03 00:00:00

  • Evaluation of the HPV 18 antibody response in Gardasil® vaccinees after 48 mo using a pseudovirion neutralization assay.

    abstract：:The pseudo-neutralization assay (PsV) described in the current report allows for the creation of HPV18 pseudovirions in order to evaluate whether the antibody responses elicited following vaccination with Gardasil(®) are sufficient to neutralize the activity of these pseudovirions in vitro. The PsV assay evaluates a b...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.19179

    authors： Roberts C,Swoyer R,Bryan J

    更新日期：2012-04-01 00:00:00

  • Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugated vaccine (PHiD-CV) co-administered with DTPa-combined vaccines

    abstract：:Prophylactic paracetamol administration impacts vaccine immune response; this study ( www.clinicaltrials.gov : NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania ...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1080/21645515.2016.1223001

    authors： Falup-Pecurariu O,Man SC,Neamtu ML,Chicin G,Baciu G,Pitic C,Cara AC,Neculau AE,Burlea M,Brinza IL,Schnell CN,Sas V,Lupu VV,François N,Swinnen K,Borys D

    更新日期：2017-03-04 00:00:00

  • Immunization services offered in Québec (Canada) pharmacies.

    abstract：:Canadian Pharmacists are easy to reach. Although Québec pharmacists are not allowed to administer vaccines, they can: (1) promote vaccination, (2) counsel patients on vaccination, (3) sell vaccines and (4) provide vaccine administration by a nurse. Our objectives were to describe immunization services given in Québec ...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.25186

    authors： Sauvageau C,Dubé E,Bradet R,Mondor M,Lavoie F,Moisan J

    更新日期：2013-09-01 00:00:00

  • Vaccination against respiratory Pseudomonas aeruginosa infection.

    abstract：:Respiratory infections caused by Pseudomonas aeruginosa are a major clinical problem globally, particularly for patients with chronic pulmonary disorders, such as those with cystic fibrosis (CF), non-CF bronchiectasis (nCFB) and severe chronic obstructive pulmonary disease (COPD). In addition, critically ill and immun...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章,评审

    doi：10.4161/hv.34296

    authors： Grimwood K,Kyd JM,Owen SJ,Massa HM,Cripps AW

    更新日期：2015-01-01 00:00:00

  • Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab.

    abstract：:Monoclonal antibody preparations have demonstrated considerable clinical utility in the treatment of specific malignancies, as well as inflammatory and infectious diseases. Antibodies are conventionally delivered by passive administration, typically requiring costly large-scale laboratory development and production. A...

    journal_title：Human vaccines & immunotherapeutics

    pub_type： 杂志文章

    doi：10.4161/hv.26498

    authors： Muthumani K,Flingai S,Wise M,Tingey C,Ugen KE,Weiner DB

    更新日期：2013-10-01 00:00:00