Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine.

abstract：:Previously, we have shown that DNA prime-protein boost is effective in eliciting neutralizing antibodies (NAb) against randomly selected HIV-1 isolates. Given the genetic diversity of HIV-1 viruses and the unique predominant subtypes in different geographic regions, it is critical to test the DNA prime-protein boost a...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang M,Zhang L,Zhang C,Hong K,Shao Y,Huang Z,Wang S,Lu S

更新日期：2012-11-01 00:00:00

abstract：:Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this t...

journal_title：Human vaccines & immunotherapeutics

authors： Palma P,Rinaldi S,Cotugno N,Santilli V,Pahwa S,Rossi P,Cagigi A

更新日期：2014-01-01 00:00:00

abstract：:Rabies is the most lethal zoonotic, vaccine-preventable viral disease in the world. Its treatment is complicated by insufficient vaccine supply and the requirement for four to five repeated injections, as commercially available inactivated rabies lack adjuvant and have low immunogenicity. In this study, we focused on ...

journal_title：Human vaccines & immunotherapeutics

authors： Ze L,Zonglin L,Ya'Nan W,Shaohui S,Huijuan Y,Wei C,Li W,Liao G

更新日期：2019-01-01 00:00:00

abstract：:How countries, particularly low- and middle-income economies, should pay the coronavirus disease 2019 (COVID-19) vaccine is an important and understudied issue. We undertook an online survey to measure the willingness-to-pay (WTP) for a COVID-19 vaccine and its determinants in Indonesia. The WTP was assessed using a s...

journal_title：Human vaccines & immunotherapeutics

authors： Harapan H,Wagner AL,Yufika A,Winardi W,Anwar S,Gan AK,Setiawan AM,Rajamoorthy Y,Sofyan H,Vo TQ,Hadisoemarto PF,Müller R,Groneberg DA,Mudatsir M

更新日期：2020-12-01 00:00:00

abstract：:This article aims to explore the trends of monoclonal antibodies (mAbs) research and commercialization, mainly to examine the development trajectories by a contrastive exploration of successful and unsuccessful mAb. This work is based on two sets of R&D project reports, consisting of 517 discontinued mAb project repor...

journal_title：Human vaccines & immunotherapeutics

authors： Lai Y,Suo S,Wang R,Kong X,Hu Y,Tang D,Shi H,Chen S,Hu H

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide, and is a leading cause of hospitalization in previously healthy individuals without predisposing risk factors or comorbidities. In this study we determined PCV13 serotype distribution in adults aged ≥50 years with radio...

journal_title：Human vaccines & immunotherapeutics

authors： Regev-Yochay G,Chowers M,Chazan B,Gonzalez E,Gray S,Zhang Z,Pride M

更新日期：2018-01-01 00:00:00

abstract：:The 4-component vaccine 4CMenB, developed against invasive disease caused by meningococcal serogroup B, is approved for use in infants in several countries worldwide. 4CMenB is mostly used as 3 + 1 schedule, except for the UK, where a 2 + 1 schedule is used, and where the vaccine showed an effectiveness of 82.9%. Here...

journal_title：Human vaccines & immunotherapeutics

authors： Biolchi A,Tomei S,Santini L,Welsch JA,Toneatto D,Gaitatzis N,Bai X,Borrow R,Giuliani MM,Mori E,Pizza M

更新日期：2019-01-01 00:00:00

abstract：:Respiratory infections caused by Pseudomonas aeruginosa are a major clinical problem globally, particularly for patients with chronic pulmonary disorders, such as those with cystic fibrosis (CF), non-CF bronchiectasis (nCFB) and severe chronic obstructive pulmonary disease (COPD). In addition, critically ill and immun...

journal_title：Human vaccines & immunotherapeutics

authors： Grimwood K,Kyd JM,Owen SJ,Massa HM,Cripps AW

更新日期：2015-01-01 00:00:00

abstract：:Measles virus (MV) is the only human virus within the morbillivirus genus of the Paramyxoviridae. The veterinary members are canine distemper virus (CDV), peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the marine morbilliviruses phocine distemper virus (PDV), dolphin morbillivirus (DMV) and...

journal_title：Human vaccines & immunotherapeutics

authors： Cosby SL,Weir L

更新日期：2018-01-02 00:00:00

abstract：:Vaccination status is more often evaluated by up-to-date vaccination coverage rather than timeliness of immunization. Delaying vaccination may be dangerous during infancy. The aim of this study was to identify the importance of potentially dangerous vaccination delay (previously defined) and determinants of these dela...

journal_title：Human vaccines & immunotherapeutics

authors： Bailly AC,Gras P,Lienhardt JF,Requillart JC,Vié-le-Sage F,Martinot A,Dubos F

更新日期：2018-04-03 00:00:00

abstract：:Two rotavirus vaccines are currently available in Japan. We estimated the incremental cost-effectiveness ratio (ICER) of routine infant rotavirus immunisation program without defining which vaccine to be evaluated, which reflects the current deliberation at the Health Science Council in charge of Immunisation and Vacc...

journal_title：Human vaccines & immunotherapeutics

authors： Hoshi SL,Kondo M,Okubo I

更新日期：2017-05-04 00:00:00

abstract：:Rotavirus gastroenteritis accounts for an estimated 130,000 GP consultations and 13,000 hospitalisations for children under 5 y old each year in England and Wales. In July 2013, an oral live attenuated rotavirus vaccine (Rotarix®) was introduced into the UK infant immunisation program as a 2 dose schedule at 2 and 3 m...

journal_title：Human vaccines & immunotherapeutics

authors： Inns T,Trindall A,Dunling-Hall S,Shankar AG

更新日期：2016-04-02 00:00:00

abstract：:Neisseria meningitidis or meningococcus is divided into 12 distinct serogroups of which A, B, C, W, X, and Y are medically most important and cause health problems in different parts of the world. The epidemiology of N. meningitidis is unpredictable over time and across geographic regions. Globally, serogroup A has be...

journal_title：Human vaccines & immunotherapeutics

authors： Bröker M,Emonet S,Fazio C,Jacobsson S,Koliou M,Kuusi M,Pace D,Paragi M,Pysik A,Simões MJ,Skoczynska A,Stefanelli P,Toropainen M,Taha MK,Tzanakaki G

更新日期：2015-01-01 00:00:00

abstract：:Post licensure surveillance of adverse events following immunization (AEFI) is a fundamental activity to improve safety and maintain public confidence in vaccines.   Since 2011, the Liguria Region has been involved in the inter-regional project of post-marketing surveillance of AEFI, coordinated by the Italian Medicin...

journal_title：Human vaccines & immunotherapeutics

authors： Alicino C,Merlano C,Zappettini S,Schiaffino S,Della Luna G,Accardo C,Gasparini R,Durando P,Icardi G

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative ne...

journal_title：Human vaccines & immunotherapeutics

authors： Fettelschoss A,Zabel F,Bachmann MF

更新日期：2014-01-01 00:00:00

abstract：:Objective: To evaluate the efficacy of an intervention utilizing patient navigators (PNs) to 1) educate families on human papillomavirus (HPV) vaccination in a clinic setting and 2) provide personalized reminders for follow-up. Method: Families with 9-17 year-old children who had no record of completing the HPV vaccin...

journal_title：Human vaccines & immunotherapeutics

authors： Berenson AB,Rupp R,Dinehart EE,Cofie LE,Kuo YF,Hirth JM

更新日期：2019-01-01 00:00:00

abstract：:We conducted a multicentre test negative case control study to estimate the 2013-14 influenza vaccine effectiveness (IVE) against hospitalised laboratory confirmed influenza in 12 hospitals in France, Italy and Spain. We included all ≥18 years hospitalised patients targeted by local influenza vaccination campaign repo...

journal_title：Human vaccines & immunotherapeutics

authors： Rondy M,Castilla J,Launay O,Costanzo S,Ezpeleta C,Galtier F,de Gaetano Donati K,Moren A

更新日期：2016-05-03 00:00:00

abstract：:Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor mi...

journal_title：Human vaccines & immunotherapeutics

authors： Collins JM,Gulley JL

更新日期：2019-01-01 00:00:00

abstract：:Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protect...

journal_title：Human vaccines & immunotherapeutics

authors： Kostinov MP,Cherdantsev AP,Kuselman AI,Akhmatova NK,Kostinova AM,Deryabina EV,Demina EO,Kostinov AM

更新日期：2018-01-01 00:00:00

abstract：:Background: Compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza B virus infections. We developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process...

journal_title：Human vaccines & immunotherapeutics

authors： Ye H,Jia S,Zhang Y,Li J,Zhu F

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:To evaluate the validity and reliability of a survey to identify vaccine hesitancy among parents. METHODS:Cross-sectional survey of parents of 19-35 month old children was conducted in Changxing County, Zhejiang Province, through a questionnaire developed for the survey of the vaccine hesitancy. Construct v...

journal_title：Human vaccines & immunotherapeutics

authors： Hu Y,Chen Y,Liang H,Wang Y

更新日期：2019-01-01 00:00:00

abstract：:DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from degradation and improve transfection efficiencies in vivo. Recen...

journal_title：Human vaccines & immunotherapeutics

authors： Cole G,McCaffrey J,Ali AA,McBride JW,McCrudden CM,Vincente-Perez EM,Donnelly RF,McCarthy HO

更新日期：2017-01-02 00:00:00

abstract：:The introduction of a serogroup A meningococcal conjugate vaccine in the African meningitis belt has been a remarkable success. Meningitis due to the serogroup A meningococcus, previously responsible for most epidemics, has fallen by 99% in vaccinated countries. Success must, however, not distract from the continuing ...

journal_title：Human vaccines & immunotherapeutics

authors： Stuart JM

更新日期：2018-05-04 00:00:00

abstract：:Anti-vaccination movement has existed as long as the vaccines themselves, but its mode of action and social influences evolved over time. Such attitude with no doubt has negative impact on vaccination rates and eradication of infectious diseases. In this study, we used an online survey to examine vaccination attitudes...

journal_title：Human vaccines & immunotherapeutics

authors： Zarobkiewicz MK,Zimecka A,Zuzak T,Cieślak D,Roliński J,Grywalska E

更新日期：2017-11-02 00:00:00

abstract：:Hepatitis B vaccine is the most effective strategy to control hepatitis B virus (HBV) infection and disease. It is considered that an anti-HBs (antibodies against HBV surface antigen) titer >10 mIU/ml, measured shortly after a complete vaccination schedule, provides protection against infection. Approximately 4-10% of...

journal_title：Human vaccines & immunotherapeutics

authors： Cassaniti I,Calarota SA,Adzasehoun KM,Chiesa A,Comolli G,Parea M,Baldanti F

更新日期：2016-11-01 00:00:00

abstract：:Rotavirus (RV) infection is the primary cause for childhood gastroenteritis worldwide. In Korea, RV infection is most common among children less than 5 years of age. This post-licensure study was conducted to further evaluate the RV vaccine (RIX4414) to provide additional local clinical data to the Korean Food and Dru...

journal_title：Human vaccines & immunotherapeutics

authors： Kim JS,Bae CW,Lee KY,Park MS,Choi YY,Kim KN,Kim JD,Park WS,Sin JB,Kim EA,Lee SG,Kim CS,Cha SH,Hong YJ,Shin SM,Shim GH,Choi KM,Yang JW,Liu A,Suryakiran PV,Han HH

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:The aim of the present study is to review the economic burden of varicella disease and the benefit of universal varicella vaccination in different settings pending its implementation in all Italian regions. MATERIALS AND METHODS:Research was conducted using PubMed, Scopus and ISI databases. Score quality ...

journal_title：Human vaccines & immunotherapeutics

authors： Unim B,Saulle R,Boccalini S,Taddei C,Ceccherini V,Boccia A,Bonanni P,La Torre G

更新日期：2013-09-01 00:00:00

abstract：:The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effecti...

journal_title：Human vaccines & immunotherapeutics

authors： Zheng Z,Diaz-Arévalo D,Guan H,Zeng M

更新日期：2018-07-03 00:00:00

abstract：:Assessing the beliefs and attitudes of Health Care Workers (HCW) to influenza and influenza vaccination can be useful in overcoming low compliance rates. The purpose of our study is to evaluate the opinion of HCW and students regarding influenza, influenza vaccine and the factors associated with vaccination compliance...

journal_title：Human vaccines & immunotherapeutics

authors： Bonaccorsi G,Lorini C,Santomauro F,Guarducci S,Pellegrino E,Puggelli F,Balli M,Bonanni P

更新日期：2013-12-01 00:00:00

abstract：:This review aims to present the unique considerations for manufacturing and the regulation of new vaccines in Muslim-populated countries such as Malaysia. Our specific objectives are to highlight vaccine production and the ingredients of concern, summarize the current mechanism for ruling and recommendations on new va...

journal_title：Human vaccines & immunotherapeutics

authors： Khoo YSK,Ghani AA,Navamukundan AA,Jahis R,Gamil A

更新日期：2020-03-03 00:00:00