Immunizations in solid organ and hematopoeitic stem cell transplant patients: A comprehensive review.

Abstract:

:The Solid Organ Transplantation (SOT) and Haematopoietic Stem Cell Transplantation (HSCT) population is continuously increasing as a result of broader indications for transplant and improved survival. Infectious diseases, including vaccine-preventable diseases, are a significant threat for this population, primarily after but also prior to transplantation. As a consequence, clinicians must ensure that patients are optimally immunized before transplantation, to provide the best protection during the early post-transplantation period, when immunosuppression is the strongest and vaccine responses are poor. After 3-6 months, inactivated vaccines immunization can be resumed. By contrast, live-attenuated vaccines are lifelong contraindicated in SOT patients, but can be considered in HSCT patients at least 2 years after transplantation, if there is no immunosuppression or graft-versus-host-disease. However, because of the advantages of live-attenuated over inactivated vaccines--and also sometimes the absence of an inactivated alternative--an increasing number of prospective studies on live vaccine immunization after transplantation are performed and give new insights about safety and immunogenicity in this population.

journal_name

Hum Vaccin Immunother

authors

L'Huillier AG,Kumar D

doi

10.1080/21645515.2015.1078043

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

2852-63

issue

12

eissn

2164-5515

issn

2164-554X

journal_volume

11

pub_type

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