Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses.

abstract：:The licensed meningococcal serogroup B vaccine, 4CMenB (Bexsero(®)), contains recombinant membrane proteins (rMenB) and outer membrane vesicles (OMV) of the New Zealand serogroup B strain. We investigated whether reducing the OMV and/or protein content influences 4CMenB immunogenicity and reactogenicity in healthy two...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Prymula R,Zuccotti GV,Xie F,Barone M,Dull PM,Toneatto D

更新日期：2014-01-01 00:00:00

abstract：:Different strategies have been proposed for the development of protein subunit vaccine candidates for tuberculosis (TB), which shows better safety than other types of candidates and the currently used Bacillus Calmette-Guérin (BCG) vaccine. In order to develop more effective protein subunits depending on the mechanism...

journal_title：Human vaccines & immunotherapeutics

authors： Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

更新日期：2015-01-01 00:00:00

abstract：:Respiratory infections caused by Pseudomonas aeruginosa are a major clinical problem globally, particularly for patients with chronic pulmonary disorders, such as those with cystic fibrosis (CF), non-CF bronchiectasis (nCFB) and severe chronic obstructive pulmonary disease (COPD). In addition, critically ill and immun...

journal_title：Human vaccines & immunotherapeutics

authors： Grimwood K,Kyd JM,Owen SJ,Massa HM,Cripps AW

更新日期：2015-01-01 00:00:00

abstract：:Disseminated bacillus Calmette-Guérin (BCG) disease is a rare and serious adverse event following immunization (AEFI) with BCG. Here, we reported two cases of disseminated BCG disease in the same family and reviewed the literature to identify another 35 cases in China. The average age at onset was 3.7 ± 2.1 months amo...

journal_title：Human vaccines & immunotherapeutics

authors： Wang J,Wu QS,Jiang MB,Xu ZH

更新日期：2020-10-20 00:00:00

abstract：:Rubella is a contagious viral disease, which mainly affects the fetus, if the mother is infected in the 1st trimester of her pregnancy. All adolescent girls (aged 11 to 19 y) and women of childbearing age are at risk of developing rubella. This disease is mild and self-limiting, and incubation period is 2-3 weeks. Hum...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P,Chawla S

更新日期：2012-06-01 00:00:00

abstract：:One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

更新日期：2020-06-02 00:00:00

abstract：:Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination is recommended for all women during each pregnancy to prevent pertussis in young infants. However, data on the safety of this protective measure are limited and conflicting. To assess maternal and infant outcomes associated with administration of this vac...

journal_title：Human vaccines & immunotherapeutics

authors： Berenson AB,Hirth JM,Rahman M,Laz TH,Rupp RE,Sarpong KO

更新日期：2016-08-02 00:00:00

abstract：:Maternal vaccination offers the opportunity to protect pregnant women and their infants against potentially serious disease. As both pregnant women and their newborns are vulnerable to severe illness, the potential public health impact of mass maternal vaccination programs is remarkable. Several high-income countries ...

journal_title：Human vaccines & immunotherapeutics

authors： Regan AK

更新日期：2016-12-01 00:00:00

abstract：:Immunocompromising conditions increase the risk of invasive pneumococcal disease (IPD). Vaccine uptake in patients with these conditions may be low in part because of concerns about decreased immunogenicity and safety in these high-risk groups. We conducted a literature search to identify publications describing antib...

journal_title：Human vaccines & immunotherapeutics

authors： Chilson E,Scott DA,Schmoele-Thoma B,Watson W,Moran MM,Isturiz R

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:NmenB vaccine (4CMenB) is now available, but studies on the cost-effectiveness of vaccine introduction in a country outbreak situation are lacking. The aim of this study was to evaluate the cost-effectiveness of 4CMenB in the context of a hypothetical epidemic outbreak in Chile. We analyzed the direct and in...

journal_title：Human vaccines & immunotherapeutics

authors： Izquierdo G,Torres JP,Santolaya ME,Valenzuela MT,Vega J,Chomali M

更新日期：2015-01-01 00:00:00

abstract：:Influenza viruses cause annual winter epidemics globally and influenza vaccination is most effective way to prevent the disease or severe outcomes from the illness, especially in developing countries. However, the majority of the world's total production capacity of influenza vaccine is concentrated in several large m...

journal_title：Human vaccines & immunotherapeutics

authors： Liu Y,Wu JY,Wang X,Chen JT,Xia M,Hu W,Zou Y,Yin WD

更新日期：2014-01-01 00:00:00

abstract：:Rotavirus (RV) and norovirus (NoV) are the 2 leading causes of acute viral gastroenteritis worldwide. We have developed a non-live NoV and RV vaccine candidate consisting of NoV virus-like particles (VLPs) and recombinant polymeric RV VP6 protein produced in baculovirus-insect cell expression system. Both components h...

journal_title：Human vaccines & immunotherapeutics

authors： Blazevic V,Malm M,Arinobu D,Lappalainen S,Vesikari T

更新日期：2016-03-03 00:00:00

abstract：:The development of a successful vaccine, which should elicit a combination of humoral and cellular responses to control or prevent infections, is the first step in protecting against infectious diseases. A vaccine may protect against bacterial, fungal, parasitic, or viral infections in animal models, but to be effecti...

journal_title：Human vaccines & immunotherapeutics

authors： Zheng Z,Diaz-Arévalo D,Guan H,Zeng M

更新日期：2018-07-03 00:00:00

abstract：:We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were mainta...

journal_title：Human vaccines & immunotherapeutics

authors： Einstein MH,Levin MJ,Chatterjee A,Chakhtoura N,Takacs P,Catteau G,Dessy FJ,Moris P,Lin L,Struyf F,Dubin G,HPV-010 Study Group.

更新日期：2014-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of respiratory tract infections in both children and elderly people. In this study we evaluated the short- and long-term protective efficacy of a single intranasal (IN) immunization with a RSV vaccine formulation consisting of a codon-optimized fusion (F) prot...

journal_title：Human vaccines & immunotherapeutics

authors： Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

更新日期：2017-12-02 00:00:00

abstract：:In tick-borne encephalitis (TBE)-endemic regions, long-term vaccination programs are efficient in preventing the disease. A booster dose of a polygeline-free inactivated TBE vaccine (Encepur Adults, GSK), administered approximately 3 years post-primary vaccination according to 1 of 3 licensed vaccination schedules in ...

journal_title：Human vaccines & immunotherapeutics

authors： Costantini M,Callegaro A,Beran J,Berlaimont V,Galgani I

更新日期：2020-09-01 00:00:00

abstract：:Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use. Despite a proven medical need, PCV vaccination in Southern Europe remained suboptimal until 2015/16. We searched PubMed for manuscripts published betwee...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira M,Castro O,Palmieri M,Efklidou S,Castagna S,Hoet B

更新日期：2017-06-03 00:00:00

abstract：OBJECTIVE:In China, Hib vaccine is a private-sector vaccine that is an option for parents to select to give to their children; it must be paid for out-of-pocket because it is not included in the government's Expanded Program on Immunization (EPI). We evaluated utilization patterns of Hib vaccine to provide evidence in ...

journal_title：Human vaccines & immunotherapeutics

authors： Li Y,Yue C,Wang Y,Zhu X,Martin K,Scherpbier RW,Liu J,Wang Z,Ma Y,Cheng H,Zhang Z,Wang Q,Li H,Xie S,Xiao Q,Wang H,An Z

更新日期：2018-04-03 00:00:00

abstract：:Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid C...

journal_title：Human vaccines & immunotherapeutics

authors： Masadeh MM,Alzoubi KH,Al-Azzam SI,Al-Agedi HS,Abu Rashid BE,Mukattash TL

更新日期：2014-01-01 00:00:00

abstract：:Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a major health problem particularly in developing countries. The available vaccines have certain limitations regarding their efficacy, and inability to induce an immune response especially in individuals under 2 years of age. Conjugate vaccines ...

journal_title：Human vaccines & immunotherapeutics

authors： Ali A,An SJ,Cui C,Haque A,Carbis R

更新日期：2012-02-01 00:00:00

abstract：:Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs...

journal_title：Human vaccines & immunotherapeutics

authors： Chen Z,He Q

更新日期：2017-04-03 00:00:00

abstract：:Last decades, the number of routine childhood vaccinations has increased considerably, which consequently has led to multiple vaccine injections per consultation. Implementation of additional vaccines will probably lead to more than 2 vaccine injections per consult, which might be a barrier for parents to vaccinate th...

journal_title：Human vaccines & immunotherapeutics

authors： Kaaijk P,Kleijne DE,Knol MJ,Harmsen IA,Ophorst OJ,Rots NY

更新日期：2014-01-01 00:00:00

abstract：:Liguria, an administrative region in northern Italy characterized by a decade of high PCV coverage in paediatric age group, has issued new PCV13 recommendations for free active immunization in adults with risk factors and subjects aged ≥ 70 years old. Main aims of this study are: (1) a descriptive epidemiology of the ...

journal_title：Human vaccines & immunotherapeutics

authors： Ansaldi F,Orsi A,Trucchi C,De Florentiis D,Ceravolo A,Coppelli M,Schiaffino S,Turello V,Rosselli R,Carloni R,Icardi G,Study Group LP,Canepa P,Sticchi L,Zanetti R,Cremonesi I,Brasesco P,Moscatelli P

更新日期：2015-01-01 00:00:00

abstract：:The 7th Asian Vaccine Conference (ASVAC 2019) was held in Yangon, Myanmar from 13 to 15, September 2019. It brought together stakeholders in the field of vaccination to address challenges and issues relevant to clinical practice and immunization programs in the region. The conference themed "Immunization: sustaining h...

journal_title：Human vaccines & immunotherapeutics

authors： Linn K,Bravo L,Goh DYT,Nelson EAS

更新日期：2020-07-02 00:00:00

abstract：:Background: We performed a systematic review to evaluate factors affecting uptake of rotavirus vaccine amongst physicians, parents and health system. Methods: We identified 15 studies that met the inclusion criteria from 790 screened studies published between Jan 2005 to Jan 2016. Results: Perceived severity of rotavi...

journal_title：Human vaccines & immunotherapeutics

authors： Apte A,Roy S,Bavdekar A,Juvekar S,Hirve S

更新日期：2018-01-01 00:00:00

abstract：:Antipoverty vaccines are the vaccines targeting a group of approximately 20 neglected tropical diseases (NTDs), as currently defined by the World Health Organization (WHO). The "antipoverty" moniker refers to the fact that NTDs trap populations in poverty due to their chronic and deleterious effects on child intellect...

journal_title：Human vaccines & immunotherapeutics

authors： Hotez PJ

更新日期：2018-01-01 00:00:00

abstract：:While the Saudi Arabian Ministry of Health has made seasonal influenza vaccination available for several years, there remains a scarcity of vaccination coverage reports outside of the capital city. Understanding factors that affect vaccine uptake is important in developing strategies to improve coverage. This analytic...

journal_title：Human vaccines & immunotherapeutics

authors： Al Hassan YT,Fabella EL,Estrella ED,Al Ramadan HA,Al Rajeh AM,Al Saleh FH

更新日期：2021-01-30 00:00:00

abstract：:Rapid production of influenza vaccine antigen is an important challenge when a new pandemic occurs. Production of recombinant antigens in plants is a quick, cost effective and up scalable new strategy for influenza vaccine production. In this study, we have characterized a recombinant influenza haemagglutinin antigen ...

journal_title：Human vaccines & immunotherapeutics

authors： Jul-Larsen Å,Madhun AS,Brokstad KA,Montomoli E,Yusibov V,Cox RJ

更新日期：2012-05-01 00:00:00

abstract：:Vaccination status is more often evaluated by up-to-date vaccination coverage rather than timeliness of immunization. Delaying vaccination may be dangerous during infancy. The aim of this study was to identify the importance of potentially dangerous vaccination delay (previously defined) and determinants of these dela...

journal_title：Human vaccines & immunotherapeutics

authors： Bailly AC,Gras P,Lienhardt JF,Requillart JC,Vié-le-Sage F,Martinot A,Dubos F

更新日期：2018-04-03 00:00:00

abstract：:Vaccines dramatically reduce infection-related morbidity and mortality. Determining factors that modulate the host response is key to rational vaccine design and demands unsupervised analysis. To longitudinally resolve influenza-specific humoral immune response dynamics we constructed vaccine response profiles of infl...

journal_title：Human vaccines & immunotherapeutics

authors： Berger CT,Greiff V,Mehling M,Fritz S,Meier MA,Hoenger G,Conen A,Recher M,Battegay M,Reddy ST,Hess C

更新日期：2015-01-01 00:00:00