Intranasal immunization with a single dose of the fusion protein formulated with a combination adjuvant induces long-term protective immunity against respiratory syncytial virus.

abstract：:Influenza can be potentially fatal to vulnerable populations, particularly those in the hospital. Canada's National Advisory Committee on Immunization recommends that health-care workers (HCW) be immunized against influenza partly to avoid infecting high-risk populations. However, influenza immunization rates among HC...

journal_title：Human vaccines & immunotherapeutics

authors： Di Castri AM,Halperin DM,McPherson CM,Nunn A,Farrar-Muir H,Kwong JC,Henry B

更新日期：2020-06-02 00:00:00

abstract：:The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection. Vaccine development may be hindered by modulation of vaccine-induce...

journal_title：Human vaccines & immunotherapeutics

authors： Ferraro A,Buonocore SM,Auquier P,Nicolas I,Wallemacq H,Boutriau D,van der Most RG

更新日期：2019-01-01 00:00:00

abstract：:Despite a publicly funded immunization program and continuous promotional efforts, vaccine uptake for seasonal influenza in Quebec (Canada) remains under its goal of 80%. Missed opportunities can explain the low influenza vaccine rates among chronically ill children. To address that, demonstration projects using the l...

journal_title：Human vaccines & immunotherapeutics

authors： Dubé E,Gagnon D,Huot C,Paré R,Jacques S,Kossowski A,Quach C,Landry M

更新日期：2014-01-01 00:00:00

abstract：:When the next pandemic emerges, will we be ready? Experts say that the number of animal to human "species jumps" is bound to increase as populations increase and the speed of travel between continents accelerates. Typical pandemic timelines no longer apply.(1) Pandemic H1N1 traveled the world in just weeks, as did SAR...

journal_title：Human vaccines & immunotherapeutics

authors： Spero D,Petrovsky N,De Groot AS

更新日期：2012-07-01 00:00:00

abstract：:High-risk human papillomavirus (HPV) types are responsible for nearly all cases of cervical cancers. Cervarix® and Gardasil® 9 are the current prophylactic vaccines available that protect against the majority of HPVs associated with cancer. Although these vaccines are highly effective, HPV vaccine implementation has b...

journal_title：Human vaccines & immunotherapeutics

authors： Kunda NK,Peabody J,Zhai L,Price DN,Chackerian B,Tumban E,Muttil P

更新日期：2019-01-01 00:00:00

abstract：:Within the past few years, several measles outbreaks have occurred in the southeast of Iran. To learn about the effectiveness of the immunization services for producing a serologic response against measles, this follow-up study was designed and implemented in the southeast of Iran. In Iran, all routine immunization se...

journal_title：Human vaccines & immunotherapeutics

authors： Zahraei SM,Izadi S,Mokhtari-Azad T

更新日期：2016-12-01 00:00:00

abstract：:The efficacy and effectiveness of influenza vaccines depend primarily on the vaccine recipient and the virus similarity to the endemic virus. Regulatory T cells (Tregs) and cytokines are known to restrict immune responses against viral infections. We conducted this study to explore the role of Tregs, cytokines, and an...

journal_title：Human vaccines & immunotherapeutics

authors： Wang SM,Tsai MH,Lei HY,Wang JR,Liu CC

更新日期：2012-09-01 00:00:00

abstract：:Human papillomavirus (HPV) infection is a major cause of cervical cancer. HPV vaccine has been shown to be highly effective in preventing HPV infection, and understanding the genotypes of HPV infection can guide the utilization of HPV vaccine. This epidemiological study aimed to investigate the genotype distribution o...

journal_title：Human vaccines & immunotherapeutics

authors： Geng Y,Liu L

更新日期：2019-01-01 00:00:00

abstract：:In tick-borne encephalitis (TBE)-endemic regions, long-term vaccination programs are efficient in preventing the disease. A booster dose of a polygeline-free inactivated TBE vaccine (Encepur Adults, GSK), administered approximately 3 years post-primary vaccination according to 1 of 3 licensed vaccination schedules in ...

journal_title：Human vaccines & immunotherapeutics

authors： Costantini M,Callegaro A,Beran J,Berlaimont V,Galgani I

更新日期：2020-09-01 00:00:00

abstract：:Polio is an acute viral disease that is still endemic in Pakistan. The polio vaccination program is facing many challenges that result in an increased number of new cases. The success of polio vaccination has been threatened in different parts of Pakistan. In the past, the immunization program was affected by differen...

journal_title：Human vaccines & immunotherapeutics

authors： Ahmad T,Khan M,Musa TH,Hui J

更新日期：2020-06-02 00:00:00

abstract：:Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Is...

journal_title：Human vaccines & immunotherapeutics

authors： Muhsen K,Kassem E,Rubenstein U,Goren S,Ephros M,Shulman LM,Cohen D

更新日期：2019-01-01 00:00:00

abstract：:Background: Rubella continues to be a leading cause of vaccine-preventable congenital birth defects and permanent organ damage, especially in developing countries. For women who are infected with the rubella virus (RV) before conception or during the first trimester of pregnancy, the unborn child has up to a 90% proba...

journal_title：Human vaccines & immunotherapeutics

authors： Kassa ZY,Hussen S,Asnake S

更新日期：2020-10-02 00:00:00

abstract：:Previously we showed that 65-kDa Mycobacterium leprae heat shock protein (Hsp65) is a target for the development of a tuberculosis vaccine. Here we evaluated peripheral blood mononuclear cells (PBMC) from healthy individuals or tuberculosis patients stimulated with two forms of Hsp65 antigen, recombinant DNA that enco...

journal_title：Human vaccines & immunotherapeutics

authors： Wowk PF,Franco LH,Fonseca DMD,Paula MO,Vianna ÉDSO,Wendling AP,Augusto VM,Elói-Santos SM,Teixeira-Carvalho A,Silva FDC,Vinhas SA,Martins-Filho OA,Palaci M,Silva CL,Bonato VLD

更新日期：2017-05-04 00:00:00

abstract：:The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor. In the liver, there is a large body of evidence showing a protective and pro-regenerative role for IL6 cis and trans signaling. While a few studies suggest a pat...

journal_title：Human vaccines & immunotherapeutics

authors： Widjaja AA,Chothani SP,Cook SA

更新日期：2020-10-02 00:00:00

abstract：:Background: The expansion of available vaccines in recent years has increased the overall costs of the vaccine program and put pressure on providers responsible for vaccination. In England in 2016-17, GP practices responsible for vaccinating their local population were paid £227 million. However, the costs to general ...

journal_title：Human vaccines & immunotherapeutics

authors： Crocker-Buque T,Mohan K,Ramsay M,Edelstein M,Mounier-Jack S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The prevalence of occult hepatitis B (HB) infection (OBI) in HB-vaccinated diabetic children has not yet been tested. Here, we aimed to determine the prevalence of OBI among HB-vaccinated children and adolescents with insulin-dependent diabetes mellitus (IDDM). RESULTS:Eighty-seven (51.2%) children had a ti...

journal_title：Human vaccines & immunotherapeutics

authors： Elrashidy H,El-Didamony G,Elbahrawy A,Hashim A,Alashker A,Morsy MH,Elwassief A,Elmestikawy A,Abdallah AM,Mohammad AG,Mostafa M,George NM,Abdelhafeez H

更新日期：2014-01-01 00:00:00

abstract：:Allergen-specific IgG produced by immune mothers is associated with less predisposition to allergy development in their children. This finding has been described by several groups over the last few decades, but the mechanisms by which maternal IgG can inhibit allergy development are still not fully understood. With th...

journal_title：Human vaccines & immunotherapeutics

authors： Victor JR

更新日期：2017-03-04 00:00:00

abstract：:One of the major obstacles to achieving complete eradication of tumors, even in the presence of circulating tumor-specific immunity, is the tumor-induced immunosuppressive environment, which includes myeloid-derived suppressor cells and regulatory T cells. Attenuated microorganisms have emerged as candidates for a nov...

journal_title：Human vaccines & immunotherapeutics

authors： Chang SY,Kim YJ,Ko HJ

更新日期：2013-08-01 00:00:00

abstract：:One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and underestimate the potent...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Plas JL,Verdijk P,Van Brummelen EMJ,Jeeninga RE,Roestenberg M,Burggraaf J,Kamerling IMC

更新日期：2020-06-02 00:00:00

abstract：:Anflu® is a seasonal trivalent inactivated split-virion influenza vaccine manufactured by Sinovac Biotech Co., Ltd. The objectives of this study were to evaluate the safety of Anflu® (2013-14 formulation: H1N1, H3N2 and BYAM) in infants and adults and its immunogenicity and cross-reactivity against mismatched influenz...

journal_title：Human vaccines & immunotherapeutics

authors： Shen Y,Hu Y,Meng F,Du W,Li W,Song Y,Ji X,Huo L,Fu Z,Yin W

更新日期：2016-05-03 00:00:00

abstract：:Neisseria meningitidis or meningococcus is divided into 12 distinct serogroups of which A, B, C, W, X, and Y are medically most important and cause health problems in different parts of the world. The epidemiology of N. meningitidis is unpredictable over time and across geographic regions. Globally, serogroup A has be...

journal_title：Human vaccines & immunotherapeutics

authors： Bröker M,Emonet S,Fazio C,Jacobsson S,Koliou M,Kuusi M,Pace D,Paragi M,Pysik A,Simões MJ,Skoczynska A,Stefanelli P,Toropainen M,Taha MK,Tzanakaki G

更新日期：2015-01-01 00:00:00

abstract：:In France, the incidence of invasive meningococcal disease (IMD) is around 1/100,000, with the following trends over the 2011-2018 period: a leading role of group B in subjects <15 years, a decrease of group C among <1 year since 2017, an increase of group W in all age groups including subjects <1 year since 2014 and ...

journal_title：Human vaccines & immunotherapeutics

authors： Taha MK,Gaudelus J,Deghmane AE,Caron F

更新日期：2020-10-02 00:00:00

abstract：:Background: To assess the knowledge and attitudes of middle school students toward vaccination, we measured their understanding of vaccine safety and effectiveness, expectations for communication with heath care providers, and their desired role in the vaccination decision-making process. Methods: A cross-sectional, s...

journal_title：Human vaccines & immunotherapeutics

authors： Herman R,McNutt LA,Mehta M,Salmon DA,Bednarczyk RA,Shaw J

更新日期：2019-01-01 00:00:00

abstract：:The usual treatments for patients with non-small-cell lung cancer (NSCLC), such as advanced lung adenocarcinoma, are unspecific and aggressive, and include lung resection, radiotherapy and chemotherapy. Recently, treatment with monoclonal antibodies and biological inhibitors has emerged as an effective alternative, ge...

journal_title：Human vaccines & immunotherapeutics

authors： Silva AP,Coelho PV,Anazetti M,Simioni PU

更新日期：2017-04-03 00:00:00

abstract：:The development of COVID-19 vaccines is occurring at a rapid pace, with the potential for a vaccine to be available within 6 months. So who should be prioritized for vaccination when in the first instance, there will be insufficient supply to meet demand? There is no doubt that health-care workers in all settings shou...

journal_title：Human vaccines & immunotherapeutics

authors： Russell FM,Greenwood B

更新日期：2020-11-03 00:00:00

abstract：:There is currently a lack of sufficient data on human papillomavirus (HPV)-attributable cervical carcinoma in China. Accordingly, we aimed to determine the prevalence and genotype distribution of HPV among women with cervical lesions in Shenzhen, in order to evaluate the potential benefit of HPV vaccination programs a...

journal_title：Human vaccines & immunotherapeutics

authors： Mai Q,Yang X,Cheng H,Wu G,Wu Z

更新日期：2020-09-22 00:00:00

abstract：:Hepatitis B vaccine is the most effective strategy to control hepatitis B virus (HBV) infection and disease. It is considered that an anti-HBs (antibodies against HBV surface antigen) titer >10 mIU/ml, measured shortly after a complete vaccination schedule, provides protection against infection. Approximately 4-10% of...

journal_title：Human vaccines & immunotherapeutics

authors： Cassaniti I,Calarota SA,Adzasehoun KM,Chiesa A,Comolli G,Parea M,Baldanti F

更新日期：2016-11-01 00:00:00

abstract：:Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment. Treatments for breast cancer have increased overall survival, but remain limited by lack of efficacy in a subset of breast cancer patients. The real challenge is...

journal_title：Human vaccines & immunotherapeutics

authors： Kieber-Emmons T,Monzavi-Karbassi B,Hutchins LF,Pennisi A,Makhoul I

更新日期：2017-02-01 00:00:00

abstract：:Rotavirus vaccines were licensed in Spain between late 2006 and early 2007. Rotavirus vaccination was recommended but not reimbursed by the Spanish National Health System. Significant coverage rates have been reached in Galicia, with an average of 47% since the period July 2007-June 2008. We aim to explore eventual va...

journal_title：Human vaccines & immunotherapeutics

authors： Martinón-Torres F,Martinón-Torres N,Bouzón Alejandro M,Redondo Collazo L,Pértega-Díaz S,Seoane-Pillado MT,Aboal Viñas J,San-Martín M

更新日期：2012-07-01 00:00:00

abstract：:Individuals infected with human immunodeficiency virus (HIV) have excess risk of developing human papillomavirus (HPV)-related disease. A substantial fraction of HPV-associated cancers is caused by HPV serotypes not included in the currently available vaccines. Among healthy women, both Cervarix(®) (HPV-16/18, GlaxoSm...

journal_title：Human vaccines & immunotherapeutics

authors： Toft L,Tolstrup M,Müller M,Sehr P,Bonde J,Storgaard M,Østergaard L,Søgaard OS

更新日期：2014-01-01 00:00:00