Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment.

Abstract:

:Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow gluten-free diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal.

journal_name

An Bras Dermatol

authors

Clarindo MV,Possebon AT,Soligo EM,Uyeda H,Ruaro RT,Empinotti JC

doi

10.1590/abd1806-4841.20142966

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

865-75; quiz 876-7

issue

6

eissn

0365-0596

issn

1806-4841

pii

S0365-05962014000600865

journal_volume

89

pub_type

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