Dermatophytes: host-pathogen interaction and antifungal resistance.

Abstract:

:Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance.

journal_name

An Bras Dermatol

authors

Peres NT,Maranhão FC,Rossi A,Martinez-Rossi NM

doi

10.1590/s0365-05962010000500009

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

657-67

issue

5

eissn

0365-0596

issn

1806-4841

pii

S0365-05962010000500009

journal_volume

85

pub_type

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