Abstract:
:Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which has shown promising results in the treatment of this entity. We report the case of a 70-year-old male with refractory Sézary syndrome in whom treatment with alemtuzumab achieved an 80% skin lesion clearance with complete haematologic and radiologic response. The treatment was discontinued after 4 months due to adverse effects, with the patient showing a sustained response without disease progression after 13 months of follow-up.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Reifs CM,Salido-Vallejo R,Garnacho-Saucedo GM,Corte-Sánchez S,González-Menchen A,García-Nieto AVdoi
10.1590/abd1806-4841.20164322subject
Has Abstractpub_date
2016-09-01 00:00:00pages
642-644issue
5eissn
0365-0596issn
1806-4841pii
S0365-05962016000500642journal_volume
91pub_type
abstract::Evolution and cost of three types of compression therapy (single layer, multilayer and Unna boot) in patients with venous ulceration were compared. The evaluation lasted two months and used photographic records and instrument based on pressure ulcer scale for healing (PUSH). Treatment with monolayer compression therap...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1590/abd1806-4841.20162980
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Although no scientific evidence has yet been published, it is widely understood that molluscum contagiosum tends to be more common and more intense in patients with atopic dermatitis. This lack of evidence led to the development of the present study. OBJECTIVES:To evaluate the prevalence of the association ...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962011000400006
更新日期:2011-07-01 00:00:00
abstract::Sexually transmitted diseases (STDs) have a significant prevalence in both the general population and pregnant women. Accordingly, we consider the physiological changes of the maternal organism that can alter the clinical course of these diseases. In addition, obstetric and neonatal complications may occur, resulting ...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章,评审
doi:10.1590/s0365-05962010000600002
更新日期:2010-11-01 00:00:00
abstract::This report presents the case of a 13-year-old female patient with history of acute myeloid leukemia, who, after a bone marrow transplant, began to vomit and experienced rapidly progressive deterioration of consciousness, in addition to disseminated erythematous-violaceous macules, and some blisters with hemorrhagic c...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1016/j.abd.2020.03.007
更新日期:2020-01-01 00:00:00
abstract::Congenital self-healing reticulohistiocytosis is the benign spectrum of Langerhans Cell Histiocytosis, characterized by cutaneous lesions at birth or in the neonatal period, absence of systemic manifestations and spontaneous resolution of clinical status. Despite the benign and often self-resolving course in most pati...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962011000400026
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Dermatomyositis affects striated muscles, skin and other organs. OBJECTIVE:To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20143422
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment. OBJECTIVES:To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and ...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20197938
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:The social reality of the albino needs to be more studied in Brazil, as myths and social segregation regarding this illness are likely to be found in the country, with psychosocial and medical implications. OBJECTIVE:As this subject has not been referenced in previous scientific articles in Brazil, this res...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20153498
更新日期:2015-07-01 00:00:00
abstract::Noonan Syndrome is one of the most common genetic syndromes and also an important differential diagnosis in children presenting with syndromic facies similar to Turner's syndrome phenotype. This syndrome is characterized by facial dysmorphism, congenital heart defects, short stature and also a wide phenotypic variatio...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20131934
更新日期:2013-07-01 00:00:00
abstract::Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is still the subject of controversy. We evaluated the efficacy of phototherapy in the treatment of parapsoriasis and its relation with TCCL. Patients diagnosed with parapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Bet...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/S0365-05962013000200028
更新日期:2013-03-01 00:00:00
abstract::Lymphangiomas are a malformation caused by the abnormal migration of lymphatic tissue, leading to failures in the communication and drainage of the lymphatic system. They usually present as groups of translucent papules and vesicles in the skin or mucous membranes. Presentation as a verrucous plaque limited to a singl...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962011000200020
更新日期:2011-03-01 00:00:00
abstract::Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromati...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20154076
更新日期:2015-11-01 00:00:00
abstract::Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids. Nevertheless, many studies on retinoids emphasize their application in treating and preventing non melanoma sk...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章,评审
doi:10.1590/abd1806-4841.20131803
更新日期:2013-07-01 00:00:00
abstract:BACKGROUNDS:One of the most frequent causes of allergic contact dermatitis of occupational origin are rubber additives, which are present in Personal Protective Equipment (PPE). The most allergenic additives of natural and synthetic gloves are thiurams, carbamates and mercapto group. OBJECTIVE:To investigate the state...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962011000500008
更新日期:2011-09-01 00:00:00
abstract::Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinfla...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章,评审
doi:10.1590/abd1806-4841.20175994
更新日期:2017-11-01 00:00:00
abstract::Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the ...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1016/j.abd.2020.04.006
更新日期:2020-01-01 00:00:00
abstract::Laugier-Hunziker syndrome is an acquired macular hyperpigmentation of the oral and genital mucosa, often associated with longitudinal melanonychia. We report a case of longitudinal melanonychia on fingernails and toenails, hutchinson's signal and lenticular pigmentation of her lips and oral mucosa. Histopathological a...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962010000500029
更新日期:2010-09-01 00:00:00
abstract::Perforating dermatoses are a group of skin diseases characterized by transepidermal elimination of dermal material. The disease is divided into two groups: the primary group and the secondary group. The classical or primary perforating dermatoses are subdivided into four types according to the eliminated dermal materi...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1590/abd1806-4841.20164619
更新日期:2016-09-01 00:00:00
abstract::Proliferating trichilemmal cyst is an uncommon neoplasm arising from the follicular isthmus, whose histopathological hallmark is the presence of trichilemmal keratinization. We describe a case of proliferating trichilemmal cyst in a 57-year-old woman with a broad clinical, radiological, macroscopic and microscopic cor...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1590/abd1806-4841.20198199
更新日期:2019-01-01 00:00:00
abstract::Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20165358
更新日期:2016-11-01 00:00:00
abstract::Although the association of multiple autoimmune diseases has already been widely described, no reports of the association between vitiligo, primary biliary cirrhosis and Sjogren's syndrome were retrieved in the SciELO and PubMed databases. The authors describe the case of a female patient who was diagnosed with primar...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1016/j.abd.2018.07.002
更新日期:2019-01-01 00:00:00
abstract::Diffuse plane normolipemic xanthoma is a rare disease, of a group of clinical syndromes called histiocytoses, characterized by the presence of yellowish or yellow-orange plaques, distributed symmetrically on the cutaneous surface and usually accompanied by xanthelasma. It affects mainly adults and it may cause discret...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962010000100010
更新日期:2010-01-01 00:00:00
abstract::The term 'angiokeratoma' includes a wide range of dermatological conditions of hyperkeratotic vascular disorders with a similar histologic combination of hyperkeratosis and superficial dermal vascular ectasia. Angiokeratomas can be classified into localized and systemic forms. Angiokeratoma of Fordyce (AKF) is a local...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20153876
更新日期:2015-05-01 00:00:00
abstract::Calciphylaxis, also known as calcific uremic arteriolopathy, is a severe complication often observed in patients with hyperparathyroidism secondary to chronic renal failure, which occurs mainly in women. It is characterized by ischemic tissue loss secondary to progressive vascular compromise. This is a rare and severe...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962012000500014
更新日期:2012-09-01 00:00:00
abstract::The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic abnormalities with eosinophilia and atypical lymphocytes, and may involve other ...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章,评审
doi:10.1590/s0365-05962012000300013
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. OBJECTIVES:To evaluate treatment response to the autologous transplantation of noncultured epidermal ...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20175700
更新日期:2017-05-01 00:00:00
abstract::Tattoos are defined as the intentional or accidental deposit of pigment into the skin. These pigments have been associated with various dermatoses such as allergic contact dermatitis, lichenoid dermatitis, photoinduced reactions, and granulomatous, sarcoid and pseudolymphomatous reactions. The objective of this report...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/s0365-05962010000500019
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE:Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT)...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章,随机对照试验
doi:10.1590/abd1806-4841.20186709
更新日期:2018-06-01 00:00:00
abstract::There are no studies about pediatric oral mucosal diseases performed by dermatologists in Brazil. This study presents the casuistics of oral mucosal diseases in children examined at the Oral Diseases Clinic at the Department of Dermatology - University of São Paulo - Brazil. Cases were retrospectively studied from the...
journal_title:Anais brasileiros de dermatologia
pub_type: 杂志文章
doi:10.1590/abd1806-4841.20165424
更新日期:2016-11-01 00:00:00
abstract::We report a 35-year-old mulatto female patient with neurofibromatosis Type 1 who presented with facial asymmetry. The patient had two lesions: florid cemento-osseous dysplasia associated with peripheral giant cell granuloma. She was referred for surgical treatment of the peripheral giant cell granuloma and the florid ...
journal_title:Anais brasileiros de dermatologia
pub_type:
doi:10.1590/abd1806-4841.20175277
更新日期:2017-03-01 00:00:00