Alemtuzumab in refractory Sézary syndrome.

Abstract:

:Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by the triad of erythroderma, lymphadenopathy and circulating atypical cells. The emergence of new molecular targets has enabled the development of drugs such as alemtuzumab, an anti-CD52 monoclonal antibody, which has shown promising results in the treatment of this entity. We report the case of a 70-year-old male with refractory Sézary syndrome in whom treatment with alemtuzumab achieved an 80% skin lesion clearance with complete haematologic and radiologic response. The treatment was discontinued after 4 months due to adverse effects, with the patient showing a sustained response without disease progression after 13 months of follow-up.

journal_name

An Bras Dermatol

authors

Reifs CM,Salido-Vallejo R,Garnacho-Saucedo GM,Corte-Sánchez S,González-Menchen A,García-Nieto AV

doi

10.1590/abd1806-4841.20164322

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

642-644

issue

5

eissn

0365-0596

issn

1806-4841

pii

S0365-05962016000500642

journal_volume

91

pub_type

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