Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma.

Abstract:

:Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development.

journal_name

An Bras Dermatol

authors

Hussein MRA

doi

10.1016/j.abd.2020.04.006

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

627-630

issue

5

eissn

0365-0596

issn

1806-4841

pii

S0365-0596(20)30178-1

journal_volume

95

pub_type

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