Abstract:
:Although the association of multiple autoimmune diseases has already been widely described, no reports of the association between vitiligo, primary biliary cirrhosis and Sjogren's syndrome were retrieved in the SciELO and PubMed databases. The authors describe the case of a female patient who was diagnosed with primary biliary cirrhosis and Sjogren's syndrome at age 54. At age 58, she developed vitiligo restricted to the face, associated with significant impairment of self-esteem and quality of life. Antinuclear antibody was negative at the onset of the condition, but became positive after phototherapy initiation. In general, the occurrence of multiple autoimmune diseases in the same patient is known as a mosaic of autoimmunity. However, specific mechanisms appear to interconnect primary biliary cirrhosis and Sjogren's syndrome, such as PDC-E2-mediated generalized epithelitis.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Abdo-Aguiar LS,Silva de Castro CCdoi
10.1016/j.abd.2018.07.002subject
Has Abstractpub_date
2019-01-01 00:00:00pages
710-712issue
6eissn
0365-0596issn
1806-4841pii
S0365-0596(19)30088-1journal_volume
94pub_type
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journal_title:Anais brasileiros de dermatologia
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