Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma.

Abstract:

:Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.

journal_name

An Bras Dermatol

authors

Mendaçolli PJ,Brianezi G,Schmitt JV,Marques ME,Miot HA

doi

10.1590/abd1806-4841.20154076

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

874-8

issue

6

eissn

0365-0596

issn

1806-4841

pii

S0365-05962015000600874

journal_volume

90

pub_type

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