How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

Abstract:

:Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.

journal_name

An Bras Dermatol

authors

Bressan AL,Pereira D,Medeiros PM,Carneiro S,Azulay-Abulafia L

doi

10.1590/abd1806-4841.20175994

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

826-829

issue

6

eissn

0365-0596

issn

1806-4841

pii

S0365-05962017000600826

journal_volume

92

pub_type

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