Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis.

Abstract:

:Actinic keratoses are premalignant lesions of the skin caused by excessive sun exposure. Lesions may become mainly squamous cell carcinoma. Cryotherapy with liquid nitrogen is one of the main treatments. In order to evaluate the response of actinic keratosis to cryotherapy by histopathology, two lesions were selected in each of 14 patients with multiple actinic keratoses. In one lesion a biopsy was performed and in the other lesion a biopsy was performed after cryotherapy. Subsequently, both biopsies were compared histologically. Of the thirteen patients who completed the study, the best results were obtained in lesions undergoing cryotherapy concerning the atypia of keratinocytes, epithelial thickness and corneal layer and lymphocytic infiltrate. Despite the small number of patients, it was concluded that, if performed correctly, cryotherapy has high efficacy in the treatment of actinic keratoses.

journal_name

An Bras Dermatol

authors

Oliveira MC,Trevisan F,Pinto CA,Xavier CA,Pinto JC

doi

10.1590/abd1806-4841.20153302

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

384-9

issue

3

eissn

0365-0596

issn

1806-4841

pii

S0365-05962015000300384

journal_volume

90

pub_type

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