Abstract:
BACKGROUND:Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal differentiation complex on chromosome 1q21. OBJECTIVE:To evaluate the polymorphisms in the filaggrin 2 gene (rs 12568784 and rs 16899374) in children and adults with atopic dermatitis and to verify the association of these with the severity of the clinical picture, presence of other allergic diseases, and socio-demographic factors. METHOD:The study was carried out with patients and control group. Questionnaires were used to evaluate ethnicity, sex, age, family history, scoring, atopic dermatitis (SCORAD), among other parameters. Genotyping of the filaggrin 2 gene was performed by real-time polymerase chain reaction. RESULTS:Forty-eight patients and 83 controls were evaluated. No correlation was found between the variables studied in patients with atopic dermatitis and polymorphisms, no significant difference between the prevalence of polymorphisms in the patients and in the control group p>0.05. STUDY LIMITS:The exclusive use of self-reported ethnicity information and the sample size. RESULTS:The results of this work can be an incentive for the study of the polymorphisms in atopic dermaititis, considering the characteristic of the Brazilian multi ethnic population. CONCLUSION:This is an unpublished work in Brazil and the first study in the world to have a control group to evaluate alterations in the gene of filaggrin 2.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Hertz A,Azulay-Abulafia L,Nascimento APD,Ohara CY,Kuschnir FC,Porto LCdoi
10.1016/j.abd.2019.07.002subject
Has Abstractpub_date
2020-01-01 00:00:00pages
173-179issue
2eissn
0365-0596issn
1806-4841pii
S0365-0596(20)30019-2journal_volume
95pub_type
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