Abstract:
BACKGROUND:Cancer is currently among the three leading causes of death after solid organ transplantation and its incidence is increasing. Non-melanoma skin cancer - squamous cell carcinoma and basal cell carcinoma - is the most common malignancy found in kidney transplant recipients (KTRs). The incidence of non-melanoma skin cancer in KTRs has not been extensively studied in Portugal. OBJECTIVES:To determine the incidence of non-melanoma skin cancer in KTRs from the largest Portuguese kidney transplant unit; and to study risk factors for non-melanoma skin cancer. METHODS:Retrospective analysis of clinical records of KTRs referred for the first time for a dermatology consultation between 2004 and 2013. A case-control study was performed on KTRs with and without non-melanoma skin cancer. RESULTS:We included 288 KTRs with a median age at transplantation of 47 years, a male gender predominance (66%) and a median transplant duration of 3.67 years. One fourth (n=71) of KTRs developed 131 non-melanoma skin cancers, including 69 (53%) squamous cell carcinomas and 62 (47%) basal cell carcinomas (ratio squamous cell carcinoma: basal cell carcinoma 1.11), with a mean of 1.85 neoplasms per patient. Forty percent of invasive squamous cell carcinomas involved at least two clinical or histological high-risk features. The following factors were associated with a higher risk of non-melanoma skin cancer: an older age at transplantation and at the first consultation, a longer transplant duration and the presence of actinic keratosis. KTRs treated with azathioprine were 2.85 times more likely to develop non-melanoma skin cancer (p=0.01). CONCLUSION:Non-melanoma skin cancer was a common reason for dermatology consultation in Portuguese KTRs. It is imperative for KTRs to have access to specialized dermatology consultation for early referral and treatment of skin malignancies.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Pinho A,Gouveia M,Cardoso JC,Xavier MM,Vieira R,Alves Rdoi
10.1590/abd1806-4841.20164891subject
Has Abstractpub_date
2016-07-01 00:00:00pages
455-62issue
4eissn
0365-0596issn
1806-4841pii
S0365-05962016000400455journal_volume
91pub_type
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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更新日期:2015-05-01 00:00:00
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journal_title:Anais brasileiros de dermatologia
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更新日期:2011-07-01 00:00:00
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journal_title:Anais brasileiros de dermatologia
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更新日期:2016-09-01 00:00:00
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journal_title:Anais brasileiros de dermatologia
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