Abstract:
BACKGROUND:Dermatophytes are filamentous keratinophilic fungi. Trichophyton rubrum is a prevalent infectious agent in tineas and other skin diseases. Drug therapy is considered to be limited in the treatment of such infections, mainly due to low accessibility of the drug to the tissue attacked and development of antifungal resistance in these microorganisms. In this context, Photodynamic Therapy is presented as an alternative. OBJECTIVE:Evaluate, in vitro, the photodynamic activity of four derivatives of Protoporphyrin IX by irradiation with LED 400 nm in T. rubrum. METHOD:Assays were subjected to irradiation by twelve cycles of ten minutes at five minute intervals. RESULT:Photodynamic action appeared as effective with total elimination of UFCs from the second irradiation cycle. CONCLUSION:Studies show that the photodynamic activity on Trichophyton rubrum relates to a suitable embodiment of the photosensitizer, which can be maximized by functionalization of peripheral groups of the porphyrinic ring.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Ramos RR,Kozusny-Andreani DI,Fernandes AU,Baptista Mda Sdoi
10.1590/abd1806-4841.20163643subject
Has Abstractpub_date
2016-04-01 00:00:00pages
135-40issue
2eissn
0365-0596issn
1806-4841pii
S0365-05962016000200135journal_volume
91pub_type
杂志文章abstract::Metastatic ovarian cancer uncommonly presents with skin metastasis. When present, skin metastases of ovarian cancer are usually localized in the vicinity of the primary tumor. We report a case of a 58-year-old woman with a rapid growing erythematous, well-defined nodule localized on the left nasal ala. A skin biopsy w...
journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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doi:10.1590/abd1806-4841.20187044
更新日期:2018-03-01 00:00:00
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