Abstract:
AIMS:The current WHO classification of thymic epithelial neoplasms describes type A and type AB thymomas as behaving 'like benign neoplasms'. However, recent published data suggest that rare cases may show more aggressive behaviour. The aim of this study was to assess the frequency of atypical cases, and to determine whether atypia is associated with more advanced disease. METHODS AND RESULTS:One hundred and twenty-one thymomas (type A, n = 68; type AB, n = 53) were retrospectively reviewed for 'atypical' features (nuclear pleomorphism, mitotic activity, and necrosis). Logistic regression was used to ascertain the association with increasing Masaoka-Koga stage. Where available, follow-up data were also reviewed. There were 72 stage I, 42 stage II, five stage III and two stage IV tumours. Only the presence of necrosis showed a significant association with increased stage in univariate and multivariate analysis. Nuclear atypia and increased mitotic activity were not associated with increasing stage of disease. CONCLUSIONS:Our data support the concept of there being more aggressive atypical variants of both type A and type AB thymoma, and suggest that the presence of necrosis could be used to predict aggressive behaviour.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Green AC,Marx A,Ströbel P,Mason M,Lim E,Jordan S,Ladas G,Dusmet M,Rice A,Nicholson AGdoi
10.1111/his.12512subject
Has Abstractpub_date
2015-05-01 00:00:00pages
884-91issue
6eissn
0309-0167issn
1365-2559journal_volume
66pub_type
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