An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.

abstract：:Schizophrenia is a severe mental disorder, characterized by a complex symptomatology and a chronic relapsing course, leading to a more or less intensive residual syndrome. The disorder has strong consequences on social functioning and on the patients' quality of life and is associated with a huge economical burden for...

journal_title：Current pharmaceutical biotechnology

authors： Moller HJ

更新日期：2012-06-01 00:00:00

abstract：:Intra-uterine growth retardation (IUGR) represents one of the major problems in perinatal medicine. IUGR is one of main causes of perinatal mortality and morbidity. A huge number and variety of established and possible causes of IUGR have been described. There are currently no data about effective treatment of this fe...

journal_title：Current pharmaceutical biotechnology

authors： Mierzynski R,Dluski D,Darmochwal-Kolarz D,Poniedziałek-Czajkowska E,Leszczynska-Gorzelak B,Kimber-Trojnar Z,Agnieszka-Wankowicz,Oleszczuk J

更新日期：2016-01-01 00:00:00

abstract：:Most cancer patients will experience moderate to severe pain and/or neuropathy during the course of their disease. Recent improvements in the primary treatment of cancer have increased the life span of cancer patients, but not necessarily their quality of life (QoL). The pain and suffering cancer patients experience m...

journal_title：Current pharmaceutical biotechnology

authors： Knopp KL,Nisenbaum ES,Arneric SP

更新日期：2011-10-01 00:00:00

abstract：:Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

journal_title：Current pharmaceutical biotechnology

authors： Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

journal_title：Current pharmaceutical biotechnology

authors： Girgis GNS

更新日期：2020-01-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial ...

journal_title：Current pharmaceutical biotechnology

authors： Gujral N,Yoo H,Bamdad F,Lee KY,Suh JW,Sunwoo H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Oxymatrine is one of the most promising alkaloids from Sophora flavescens for its excellent pharmacological effects. OBJECTIVE:The aim of this research is to assess the biopharmaceutical and pharmacokinetic activities of oxymatrine, and clarify its mechanisms of absorption and metabolism. METHODS:The biolo...

journal_title：Current pharmaceutical biotechnology

authors： Wang HQ,Chen FH,Wang L,Chi LQ,Wang GH

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concent...

journal_title：Current pharmaceutical biotechnology

authors： Giannakopoulos K,Hoffmann U,Ansari U,Bertsch T,Borggrefe M,Akin I,Behnes M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent claudication. However, numerous research groups report that PTX also may potentially be used in the anticancer therapy following one of the main trends in the nowadays medicine - combined anticancer therapy. SCOPE OF REVIEW:The re...

journal_title：Current pharmaceutical biotechnology

authors： Golunski G,Woziwodzka A,Piosik J

更新日期：2018-01-01 00:00:00

abstract：:Tryparedoxin peroxidase (TryP) is a key enzyme of the trypanothione-dependent metabolism for removal of oxidative stress in leishmania. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. Inhibitors of this enzyme are presumed to be antilesihmania drugs and structura...

journal_title：Current pharmaceutical biotechnology

authors： Singh BK,Dubey VK

更新日期：2009-09-01 00:00:00

abstract：:X-ray is a non-thermal technology that has shown good efficacy in reducing pathogenic and spoilage bacteria, viruses and parasites. X-ray hygiene technology resulted in a high microbial loss in numerous food products, such as dairy products, ready-to-eat shrimp, oysters, fresh products, strawberries, shredded iceberg ...

journal_title：Current pharmaceutical biotechnology

authors： Zehi ZB,Afshari A,Noori SMA,Jannat B,Hashemi M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Alfalfa and red clover are the most widespread and most important perennial legumes, primarily used as a high-quality feed for livestock. Both alfalfa and red clover, as well as some other plant species from Fabaceae family, are a rich natural source of phytoestrogens, nonsteroidal compounds with an estrogen...

journal_title：Current pharmaceutical biotechnology

authors： Tucak M,Horvat D,Cupic T,Krizmanic G,Tomas V,Ravlic M,Popovic S

更新日期：2018-01-01 00:00:00

abstract：:Celiac Disease (CD) is an immune-mediated enteropathy, generally of the proximal intestine, that occurs in genetically susceptible individuals triggered by the ingestion of gluten. The incidence and frequency of CD are increasing, and it is predicted that CD affects approximately 1% of the people worldwide. The common...

journal_title：Current pharmaceutical biotechnology

authors： Azimi T,Nasser A,Shariati A,Shiadeh SMJ,Safari H,Alizade-Sani M,Taghipour A,Dehghan A

更新日期：2020-01-01 00:00:00

abstract：:The recent developement of platelet concentrate for surgical use is an evolution of the fibrin glue technologies used since many years. The initial concept of these autologous preparations was to concentrate platelets and their growth factors in a plasma solution, and to activate it into a fibrin gel on a surgical sit...

journal_title：Current pharmaceutical biotechnology

authors： Bielecki T,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Three clones of Cabernet Franc (Nos. 02, 010 and 012) were selected in the last phase of clonal selection in Serbia. Wines made from each clone were assessed for quality parameters and taste during five consecutive vintages (2008-2012) and compared to the standard. The wine quality was determined based on th...

journal_title：Current pharmaceutical biotechnology

authors： Popovic-Djordjevic J,Pejin B,Dramicanin A,Jovic S,Vujovic D,Zunic D,Ristic R

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The uniqu...

journal_title：Current pharmaceutical biotechnology

authors： Saeedi M,Nezhad MS,Mehranfar F,Golpour M,Esakandari MA,Rashmeie Z,Ghorbani M,Nasimi F,Hoseinian SN

更新日期：2020-09-07 00:00:00

abstract：:Excessive cell proliferation contributes to the pathobiology of human diseases with a high health and socio-economic impact, including cancer and vascular occlusive diseases (e. g., atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel bypass graft failure). Recent advances in the understanding of ...

journal_title：Current pharmaceutical biotechnology

authors： Ivorra C,Samyn H,Edo MD,Castro C,Sanz-González SM,Déez-Juan A,Andrés V

更新日期：2003-02-01 00:00:00

abstract：:Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

journal_title：Current pharmaceutical biotechnology

authors： Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

更新日期：2011-10-01 00:00:00

abstract：AIMS:Globally Scientists are working to find more efficient antimicrobial drugs to treat microbial infections and kill drug-resistant bacteria. BACKGROUND:Despite the availability of numerous antimicrobial drugs bacterial infections still poses a serious threat to global health. Due to a constant decline in the effect...

journal_title：Current pharmaceutical biotechnology

authors： Khan K,Qureshi MA,Azam A,Moinuddin,Musarrat J,Javed S

更新日期：2021-01-18 00:00:00

abstract：:Many theoretical models of molecular interactions, biochemical and chemical reactions are described on the single-molecule level, although our knowledge about the biochemical/chemical structure and dynamics primarily originates from the investigation of many-molecule systems. At present, there are four experimental pl...

journal_title：Current pharmaceutical biotechnology

authors： Földes-Papp Z,Baumann G,Demel U,Tilz GP

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Although the stability of proteins is of significance to maintain protein function for therapeutical applications, this remains a challenge. Herein, a general method of preserving protein stability and function was developed using gelatin films. METHODS:Enzymes immobilized onto films composed of gelatin and...

journal_title：Current pharmaceutical biotechnology

authors： Zhang L,Shen Y,Lu W,Guo L,Xiang M,Zhang D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：AIM OF THE STUDY:To assess tramadol and O-desmethyltramadol (M1) concentrations and their correlations with analgesia in patients with cancer pain. PATIENTS AND METHODS:Thirty opioid-naive patients with nociceptive pain intensity on VAS (visual analogue scale) > 40 received controlled-release tramadol as the first (15...

journal_title：Current pharmaceutical biotechnology

authors： Leppert W,Mikolajczak P

更新日期：2011-02-01 00:00:00

abstract：:Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is expressed most abundantly in the parathyroid glands and kidney. It plays key role in these two organs because it senses changes in extracellular calcium and regulates PTH secretion and calcium reabsorption to suit the extracel...

journal_title：Current pharmaceutical biotechnology

authors： Vezzoli G,Soldati L,Gambaro G

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Sexual dysfunction and infertility are conditions with high prevalence in the general population. Nutritional factors have been reported to have an impact on sexual and reproductive health. OBJECTIVE:The aim of this review is to summarize the data on nutritional factors that have influence on male and femal...

journal_title：Current pharmaceutical biotechnology

authors： Silva T,Jesus M,Cagigal C,Silva C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...

journal_title：Current pharmaceutical biotechnology

authors： El-Aziz AMA,Shaker MA,Shaaban MI

更新日期：2019-01-01 00:00:00

abstract：:In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

journal_title：Current pharmaceutical biotechnology

authors： De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

更新日期：2012-12-01 00:00:00

abstract：:TGF-β isoforms (TGF-β1, -β2, and -β3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs, including the ...

journal_title：Current pharmaceutical biotechnology

authors： Hinck AP,O'Connor-McCourt MD

更新日期：2011-12-01 00:00:00