Abstract:
:Neph et al. (2012) (Circuitry and dynamics of human transcription factor regulatory networks. Cell, 150: 1274-1286) reported the transcription factor (TF) regulatory networks of 41 human cell types using the DNaseI footprinting technique. This provides a valuable resource for uncovering regulation principles in different human cells. In this paper, the architectures of the 41 regulatory networks and the distributions of housekeeping and specific regulatory interactions are investigated. The TF regulatory networks of different human cell types demonstrate similar global three-layer (top, core and bottom) hierarchical architectures, which are greatly different from the yeast TF regulatory network. However, they have distinguishable local organizations, as suggested by the fact that wiring patterns of only a few TFs are enough to distinguish cell identities. The TF regulatory network of human embryonic stem cells (hESCs) is dense and enriched with interactions that are unseen in the networks of other cell types. The examination of specific regulatory interactions suggests that specific interactions play important roles in hESCs.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Zhang S,Tian D,Tran NH,Choi KP,Zhang Ldoi
10.1093/nar/gku923subject
Has Abstractpub_date
2014-11-10 00:00:00pages
12380-7issue
20eissn
0305-1048issn
1362-4962pii
gku923journal_volume
42pub_type
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