Abstract:
:Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Alneberg J,Bjarnason BS,de Bruijn I,Schirmer M,Quick J,Ijaz UZ,Lahti L,Loman NJ,Andersson AF,Quince Cdoi
10.1038/nmeth.3103subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1144-6issue
11eissn
1548-7091issn
1548-7105pii
nmeth.3103journal_volume
11pub_type
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