Abstract：
:We introduce PyClone, a statistical model for inference of clonal population structures in cancers. PyClone is a Bayesian clustering method for grouping sets of deeply sequenced somatic mutations into putative clonal clusters while estimating their cellular prevalences and accounting for allelic imbalances introduced by segmental copy-number changes and normal-cell contamination. Single-cell sequencing validation demonstrates PyClone's accuracy.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Roth A,Khattra J,Yap D,Wan A,Laks E,Biele J,Ha G,Aparicio S,Bouchard-Côté A,Shah SPdoi
10.1038/nmeth.2883subject
Has Abstractpub_date
2014-04-01 00:00:00pages
396-8issue
4eissn
1548-7091issn
1548-7105pii
nmeth.2883journal_volume
11pub_type
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