Abstract:
:Pulmonary arterial hypertension (PAH) is a devastating disease without effective treatment. Despite decades of research and the development of novel treatments, PAH remains a fatal disease, suggesting an urgent need for better understanding of the pathogenesis of PAH. Recent studies suggest that microRNAs (miRNAs) are dysregulated in patients with PAH and in experimental pulmonary hypertension. Furthermore, normalization of a few miRNAs is reported to inhibit experimental pulmonary hypertension. We have reviewed the current knowledge about miRNA biogenesis, miRNA expression pattern, and their roles in regulation of pulmonary artery smooth muscle cells, endothelial cells, and fibroblasts. We have also identified emerging trends in our understanding of the role of miRNAs in the pathogenesis of PAH and propose future studies that might lead to novel therapeutic strategies for the treatment of PAH.
journal_name
Am J Respir Cell Mol Biolauthors
Zhou G,Chen T,Raj JUdoi
10.1165/rcmb.2014-0166TRsubject
Has Abstractpub_date
2015-02-01 00:00:00pages
139-51issue
2eissn
1044-1549issn
1535-4989journal_volume
52pub_type
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