Rituximab in the treatment of autoimmune haemolytic anaemia.

abstract：:1 The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The saliva/plasma ratio was 0.77 +/- 0.24 (s.d.) and showed no time-dependence being rapidly established following intravenous...

journal_title：British journal of clinical pharmacology

authors： Juma FD,Rogers HJ,Trounce JR

更新日期：1979-11-01 00:00:00

abstract：AIMS:Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healthy subjects after ing...

journal_title：British journal of clinical pharmacology

authors： Andersen V,Pedersen N,Larsen NE,Sonne J,Larsen S

更新日期：2002-08-01 00:00:00

abstract：AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

journal_title：British journal of clinical pharmacology

authors： El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

更新日期：2020-12-08 00:00:00

abstract：:Herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. As importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiv...

journal_title：British journal of clinical pharmacology

authors： Heinrich M

更新日期：2015-07-01 00:00:00

abstract：:Systemic cardiovascular effects during chronic treatment with topical minoxidil vs placebo were evaluated using a double-blind, randomized design for two parallel groups (n = 20 for minoxidil, n = 15 for placebo). During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-...

journal_title：British journal of clinical pharmacology

authors： Leenen FH,Smith DL,Unger WP

更新日期：1988-10-01 00:00:00

abstract：AIM:To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). METHOD:In this two part multiple crossover trial in 40 healthy subjects, DE 150 mg was given alone or with verapamil at different doses, duration of treatment (single vs. m...

journal_title：British journal of clinical pharmacology

authors： Härtter S,Sennewald R,Nehmiz G,Reilly P

更新日期：2013-04-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：AIMS:The aims of the study were to characterize the pharmacokinetics (PK) of selumetinib (AZD6244; ARRY-142886), a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor in clinical development for various indications, and its N-desmethyl metabolite in healthy volunteers, and evaluate clinically important covariat...

journal_title：British journal of clinical pharmacology

authors： Patel P,Howgate E,Martin P,Carlile DJ,Aarons L,Zhou D

更新日期：2018-01-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：AIMS:The aim was to assess the impact of a campaign for general practitioners (GPs) to reduce clinically-important drug-drug interactions (DDIs) in poly-treated elderly patients. METHODS:We compiled a list of 53 DDIs and analyzed reimbursed prescriptions dispensed to poly-treated (≥four drugs) elderly (>65 years) pati...

journal_title：British journal of clinical pharmacology

authors： Raschi E,Piccinni C,Signoretta V,Lionello L,Bonezzi S,Delfino M,Di Candia L,Di Castri L,Pieraccini F,Carati D,Poluzzi E,De Ponti F,Emilia-Romagna elderly poly-treated patients research group.

更新日期：2015-12-01 00:00:00

abstract：:Widespread use of cocaine and its attendant toxicity has produced a wealth of benchwork studies and small animal investigations that evaluated the effects of cocaine on the cardiovascular system. Despite this wealth of knowledge, very little is known about the frequency or types of arrhythmias in patients with signifi...

journal_title：British journal of clinical pharmacology

authors： Hoffman RS

更新日期：2010-05-01 00:00:00

abstract：:1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and...

journal_title：British journal of clinical pharmacology

authors： van der Kleijn E,Vree TB,Baars AM,Wijsman R,Edmunds LC,Knop HJ

更新日期：1981-01-01 00:00:00

abstract：:Little is known about the administration of direct-acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, serious...

journal_title：British journal of clinical pharmacology

authors： Bonaldo G,Vaccheri A,Motola D

更新日期：2020-08-01 00:00:00

abstract：AIMS:To study the impact of risperidone (RISP) on clozapine (CLZ) biotransformation in vitro in microsomal fractions containing varying expression of CYP oxidases and in vivo in patients. METHODS:Human liver microsomes (n= 11) were assessed for expression of CYPs 1A2, 2D6 and 3A4, because these enzymes mediate RISP an...

journal_title：British journal of clinical pharmacology

authors： Chetty M,d'Esposito F,Zhang WV,Glen J,Dore G,Stankovic Z,Edwards RJ,Ramzan I,Murray M

更新日期：2009-10-01 00:00:00

abstract：:1 Forty-one patients with essential hypertension, stages I, II, and III, were treated with captopril alone or in combination with hydrochlorothiazide. Forty two percent were responsive to captopril alone, while the remaining 58% also required the diuretic. The need for the diuretic was related to the phase of hyperten...

journal_title：British journal of clinical pharmacology

authors： Rabinad Estrada E,Ingelmo Morin M,Martinez Amenos A,Alsina J,Balcells Gorina A

更新日期：1982-01-01 00:00:00

abstract：AIMS:Voriconazole is a novel triazole with broad-spectrum antifungal activity. It is likely that some patients receiving voriconazole may also require treatment with the anticoagulant warfarin. Cytochrome P450 isoenzymes are important in the metabolism of both these drugs. This study investigated the effect of voricona...

journal_title：British journal of clinical pharmacology

authors： Purkins L,Wood N,Kleinermans D,Nichols D

更新日期：2003-12-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in...

journal_title：British journal of clinical pharmacology

authors： Ma Z,Liu H,Wu B

更新日期：2014-03-01 00:00:00

abstract：AIMS:To quantify usage of COX-2 inhibitors compared with nonselective NSAIDs and to determine their impact (including financial) on the co-prescription of antipeptic ulcer (anti-PU) drugs. METHODS:The Irish General Medical Services prescription database (covering 1.2 million people) was examined for NSAID prescription...

journal_title：British journal of clinical pharmacology

authors： Teeling M,Bennett K,Feely J

更新日期：2004-03-01 00:00:00

abstract：:In order to clarify the characteristics of absorption of 5-aminosalicylic acid (5-ASA) from the colon, a neutral solution was instilled into the right part of the colon and the rectum, respectively, in six volunteers. A laxative (bisacodyl) and liquid meals were given prior to each instillation. No significant differe...

journal_title：British journal of clinical pharmacology

authors： Bondesen S,Schou JB,Pedersen V,Rafiolsadat Z,Hansen SH,Hvidberg EF

更新日期：1988-02-01 00:00:00

abstract：AIMS:We aimed to examine the frequency of high-dose (defined as mean chlorpromazine mg equivalent doses above 1000) antipsychotic prescriptions in schizophrenia and their clinical correlates in the context of a comparison between studies in 2001 and 2004 within six East Asian countries and territories. METHODS:Prescri...

journal_title：British journal of clinical pharmacology

authors： Sim K,Su HC,Fujii S,Yang SY,Chong MY,Ungvari G,Si T,He YL,Chung EK,Chan YH,Shinfuku N,Kua EH,Tan CH,Sartorius N

更新日期：2009-01-01 00:00:00

abstract：AIMS:The aim of this study was to determine the potential influence of variables such as the cell content in the fluid, and serum levels, on the concentrations of ceftibuten, cefixime and azithromycin in the middle ear fluid of patients suffering from acute otitis media. METHODS:This randomized, open study compared th...

journal_title：British journal of clinical pharmacology

authors： Scaglione F,Demartini G,Dugnani S,Arcidiacono MM,Pintucci JP,Fraschini F

更新日期：1999-03-01 00:00:00

abstract：:1 The properties of a recently introduced digitalis glycoside, 4-beta-methyl digoxin (medigoxin) were compared to those of a standard digoxin preparation. Using a radioimmunoassay (RIA) technique, serial plasma levels were recorded for 8 h following a single oral dose in five fasting volunteer subjects, and urinary gl...

journal_title：British journal of clinical pharmacology

authors： Hayward RP,Greenwood H,Hamer J

更新日期：1978-07-01 00:00:00

abstract：:1 The bronchodilating efficacy and the degree of beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline were determined in seven subjects who exhibited histamine-induced bronchoconstriction. 2 Rimiterol, 0.5 (high dose) and 0.05 (low dose) mug kg-1 min-1, salbutamol, 0.3 and 0.03 mug kg-1 min-1, isop...

journal_title：British journal of clinical pharmacology

authors： Marlin GE,Turner P

更新日期：1975-02-01 00:00:00

abstract：AIMS:This study aimed to develop a population pharmacokinetic model for quantitative evaluation of the influence of genetic variants in metabolic enzymes and transporters on lamotrigine pharmacokinetics while taking into account the influence of various clinical, biochemical and demographic factors. METHODS:We include...

journal_title：British journal of clinical pharmacology

authors： Milosheska D,Lorber B,Vovk T,Kastelic M,Dolžan V,Grabnar I

更新日期：2016-08-01 00:00:00

abstract：:Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subseq...

journal_title：British journal of clinical pharmacology

authors： Klotz U,Ziegler G,Rosenkranz B,Mikus G

更新日期：1986-11-01 00:00:00

abstract：:The pharmacokinetics of metoclopramide have been studied in nine children receiving the drug as prophylaxis for cytotoxic induced vomiting. Plasma concentrations of metoclopramide have also been studied in three children with dystonic reactions to the drug. The pharmacokinetics in children were similar to those report...

journal_title：British journal of clinical pharmacology

authors： Bateman DN,Craft AW,Nicholson E,Pearson AD

更新日期：1983-05-01 00:00:00

abstract：:Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects i...

journal_title：British journal of clinical pharmacology

authors： Cushley MJ,Wee LH,Holgate ST

更新日期：1986-10-01 00:00:00

abstract：:1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients--those who have not received digoxin, those during the early phases of treatment, those...

journal_title：British journal of clinical pharmacology

authors： Ford AR,Aronson JK,Grahame-Smith DG,Carver JG

更新日期：1979-08-01 00:00:00

abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...

journal_title：British journal of clinical pharmacology

authors： Seidling HM,Lampert A,Lohmann K,Schiele JT,Send AJ,Witticke D,Haefeli WE

更新日期：2013-09-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Structured medication interviews improve the medication history upon hospitalization. Pharmacy records are valid lists of the prescribed medications available to individual patients. In Denmark, treating doctors now have access to their patients' pharmacy records through a real-...

journal_title：British journal of clinical pharmacology

authors： Glintborg B,Poulsen HE,Dalhoff KP

更新日期：2008-02-01 00:00:00