In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation.

abstract：:The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphi...

journal_title：British journal of clinical pharmacology

authors： Choonara I,Lawrence A,Michalkiewicz A,Bowhay A,Ratcliffe J

更新日期：1992-11-01 00:00:00

abstract：AIMS:Antidepressant use has increased in the last decade. Several studies have suggested a possible association between maternal antidepressant use and teratogenic effects. METHODS:The pharmacy prescription database IADB.nl was used for a cohort study in which laxative and antidiarrhoeal medication use in children aft...

journal_title：British journal of clinical pharmacology

authors： Nijenhuis CM,ter Horst PG,van Rein N,Wilffert B,de Jong-van den Berg LT

更新日期：2012-01-01 00:00:00

abstract：:1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...

journal_title：British journal of clinical pharmacology

authors： Walley T,Tsao Y,Scott A,Mackay E,Vandenburg M,Breckenridge A

更新日期：1993-06-01 00:00:00

abstract：AIM:Identify and quantify factors describing variability of amikacin clearance in preterm neonates at birth. METHODS:Population pharmacokinetics of amikacin were estimated in a cohort of 205 extreme preterm neonates [post conception age (PCA) 27.8, SD 1.8, range 24-30 weeks; weight 1.07, SD 0.34, range 0.45-1.98 kg, p...

journal_title：British journal of clinical pharmacology

authors： Allegaert K,Anderson BJ,Cossey V,Holford NH

更新日期：2006-01-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:The effects of bopindolol, a new beta-adrenoceptor blocker, on the exercise tolerance of 12 in-patients, mean age 57 (5 years), with stable angina pectoris and documented coronary artery disease were evaluated. All patients received on 4 different days a single oral dose of bopindolol 0.5 mg, bopindolol 1.0 mg, bopind...

journal_title：British journal of clinical pharmacology

authors： Carboni GP,Scardovi AB,D'Ermo M,Prati PL

更新日期：1991-12-01 00:00:00

abstract：:1 The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The saliva/plasma ratio was 0.77 +/- 0.24 (s.d.) and showed no time-dependence being rapidly established following intravenous...

journal_title：British journal of clinical pharmacology

authors： Juma FD,Rogers HJ,Trounce JR

更新日期：1979-11-01 00:00:00

abstract：:1. The antisecretory responses to pH-feedback controlled (maximum dose 800 mg 24 h-1) and fixed-dose (0.25 mg kg-1 h-1) continuous infusions of ranitidine were compared in a randomised, placebo-controlled, cross-over study in 10 healthy male volunteers. 2. To assess tolerance during repeated dosing with ranitidine, th...

journal_title：British journal of clinical pharmacology

authors： Wilder-Smith CH,Halter F,Häcki W,Merki HS

更新日期：1992-05-01 00:00:00

abstract：:1. Alfuzosin is a post-synaptic alpha-adrenoceptor antagonist with antihypertensive and peripheral vasodilator properties. 2. We measured the effect of alfuzosin, 5 mg, on sympathetically-mediated venoconstriction by changes in the venous reflex response (VRR) in a randomised, double-blind, placebo-controlled, crossov...

journal_title：British journal of clinical pharmacology

authors： Sinclair AJ,Davies IB,Warrington SJ

更新日期：1989-01-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：:The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly...

journal_title：British journal of clinical pharmacology

authors： Watt AH,Bayer A,Routledge PA,Swift CG

更新日期：1989-02-01 00:00:00

abstract：:A method is described for the simultaneous determination of amodiaquine (AQ) and desethylamodiaquine (AQm) in plasma, urine, whole blood and packed red cells. After oral administration of AQ (600 mg) to seven healthy subjects, absorption of AQ was rapid, reaching peak concentrations in plasma, whole blood, and packed ...

journal_title：British journal of clinical pharmacology

authors： Winstanley P,Edwards G,Orme M,Breckenridge A

更新日期：1987-01-01 00:00:00

abstract：:1. We studied the effects of pre-treatment with oral indomethacin (25 mg four times daily for 3 days) on the pharmacokinetics, haemodynamics and diuretic properties of oral felodipine (10 mg single dose) in 12 healthy male volunteers using a placebo controlled double-blind four-way crossover protocol. 2. Felodipine wi...

journal_title：British journal of clinical pharmacology

authors： Hardy BG,Bartle WR,Myers M,Bailey DG,Edgar B

更新日期：1988-11-01 00:00:00

abstract：:1. Less than 5% of a dose of the conventional oral formulation of cyclosporin, Sandimmun, is absorbed in liver transplant recipients with external biliary drainage, necessitating intravenous administration of the drug and exposing the patient to increased risk of severe side-effects. 2. We compared the pharmacokinetic...

journal_title：British journal of clinical pharmacology

authors： Trull AK,Tan KK,Tan L,Alexander GJ,Jamieson NV

更新日期：1995-06-01 00:00:00

abstract：:Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P les...

journal_title：British journal of clinical pharmacology

authors： Rae SA,Williams IA,English J,Baylis EM

更新日期：1982-09-01 00:00:00

abstract：:1. The dose-related effects of azapropazone on (i) event-related and spontaneous EEG-activity and (ii) the subjects' pain ratings were investigated using an experimental human pain model based on both chemo-somatosensory event-related potentials (CSSERP) and subjects' pain ratings. 2. Healthy subjects (n = 20) partici...

journal_title：British journal of clinical pharmacology

authors： Lötsch J,Mohammadian P,Hummel T,Florin S,Brune K,Geisslinger G,Kobal G

更新日期：1995-12-01 00:00:00

abstract：:1 The properties of a recently introduced digitalis glycoside, 4-beta-methyl digoxin (medigoxin) were compared to those of a standard digoxin preparation. Using a radioimmunoassay (RIA) technique, serial plasma levels were recorded for 8 h following a single oral dose in five fasting volunteer subjects, and urinary gl...

journal_title：British journal of clinical pharmacology

authors： Hayward RP,Greenwood H,Hamer J

更新日期：1978-07-01 00:00:00

abstract：:1. The pharmacokinetics of proguanil were evaluated in patients with acute P. falciparum malaria receiving concomitantly proguanil hydrochloride and atovaquone. The population consisted of 203 Blacks, 112 Orientals and 55 Malays; 274 males and 96 females. Of the 370 patients, 114 and 256 patients were classified as 'p...

journal_title：British journal of clinical pharmacology

authors： Hussein Z,Eaves CJ,Hutchinson DB,Canfield CJ

更新日期：1996-11-01 00:00:00

abstract：:1. Mizolastine, a new benzimidazole derivative with potent selective, non-sedative H1-histamine antagonist activity was compared with terfenadine, cetirizine and loratadine using the histamine-induced wheal and flare model in healthy volunteers. 2. Study design was a five way double-blind crossover design using a sing...

journal_title：British journal of clinical pharmacology

authors： Rosenzweig P,Caplain H,Chaufour S,Ulliac N,Cabanis MJ,Thebault JJ

更新日期：1995-11-01 00:00:00

abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

journal_title：British journal of clinical pharmacology

authors： Krueger H,Müller-Limmroth W

更新日期：1983-01-01 00:00:00

abstract：AIM:To describe the time to clinical events (death, disability, cognitive impairment and depression) in Parkinson's disease using the time course of disease status and treatment as explanatory variables. METHODS:Disease status based on the Unified Parkinson's Disease Rating Scale (UPDRS) and the time to clinical outco...

journal_title：British journal of clinical pharmacology

authors： Vu TC,Nutt JG,Holford NH

更新日期：2012-08-01 00:00:00

abstract：:The hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity in both well and under-resourced settings. Maternal, fetal, and neonatal complications of the HDP are concentrated among, but not limited to, women with pre-eclampsia. Pre-eclampsia is a systemic disorder of endotheli...

journal_title：British journal of clinical pharmacology

authors： Magee LA,Abalos E,von Dadelszen P,Sibai B,Easterling T,Walkinshaw S,CHIPS Study Group.

更新日期：2011-09-01 00:00:00

abstract：:1. The purpose of this study was to determine the effects of cardiac output on distribution and elimination kinetics of the marker compound sorbitol. 2. The disposition kinetics of sorbitol were investigated after rapid intravenous injection and arterial sampling in nine patients who had undergone cardiac catheterizat...

journal_title：British journal of clinical pharmacology

authors： Weiss M,Hübner GH,Hübner IG,Teichmann W

更新日期：1996-04-01 00:00:00

abstract：:Since hepatic clearance of ICG is reduced by H2-receptor antagonists in normal subjects, it has been suggested that they reduce liver blood flow. We have studied the effect of intravenous ranitidine on ICG clearance in twelve patients with chronic liver disease. Wedged and free hepatic venous pressure were measured be...

journal_title：British journal of clinical pharmacology

authors： Dunk AA,Jenkins WJ,Burroughs AK,Walt RP,Osuafor TO,Sherlock S,Mackie S,Dick R

更新日期：1983-08-01 00:00:00

abstract：AIM:Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive population pharmacokin...

journal_title：British journal of clinical pharmacology

authors： Piana C,Zhao W,Adkison K,Burger D,Jacqz-Aigrain E,Danhof M,Della Pasqua O

更新日期：2014-05-01 00:00:00

abstract：:1. Fifty-four depressive in-patients aged 18-45 yr, were treated at random, in double-blind conditions, with mianserin 60 mg daily or imipramine 150 mg daily in three divided doses for 4 weeks. Nitrazepam and diazepam were also allowed if necessary. 2. There was no significant difference in antidepressant efficacy bet...

journal_title：British journal of clinical pharmacology

authors： Pichot P,Dreyfus JF,Pull C

更新日期：1978-01-01 00:00:00

abstract：:1 The effects of the thromboxane synthetase inhibitor dazoxiben (UK 37248) on haemodynamics, blood gases, thromboxane and prostacyclin release and on arrhythmias were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. 2 Ten minutes after the administration of UK 37248 2 mg...

journal_title：British journal of clinical pharmacology

authors： Coker SJ,Parratt JR

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this randomized, double-blind, crossover trial was to compare the hypotensive effects of a fixed combination of captopril (C) 50 mg and hydrochlorothiazide (HCTZ) 25 mg (C 50/HCTZ 25) once daily with those of a fixed combination of C 25 mg and HCTZ 12.5 mg (C 25/HCTZ 12.5) twice daily. We studied 199 pa...

journal_title：British journal of clinical pharmacology

authors： Lacourcière Y,Poirier L,Provencher P,Guivarc'h PH

更新日期：1991-07-01 00:00:00

abstract：:The steady-state pharmacokinetic interaction between nefazodone and cimetidine was evaluated in a three-period crossover study consisting of three treatments of 1 week duration with a 1 week washout between treatments. The 18 healthy, male study subjects received: nefazodone hydrochloride 200 mg twice daily (every 12 ...

journal_title：British journal of clinical pharmacology

authors： Barbhaiya RH,Shukla UA,Greene DS

更新日期：1995-08-01 00:00:00

abstract：AIMS:To summarize and extend the main conclusions and recommendations relevant to drug management during acute kidney disease (AKD) as agreed at the 16th Acute Disease Quality Initiative (ADQI) consensus conference. METHODS:Using a modified Delphi method to achieve consensus, experts attending the 16th ADQI consensus ...

journal_title：British journal of clinical pharmacology

authors： Ostermann M,Chawla LS,Forni LG,Kane-Gill SL,Kellum JA,Koyner J,Murray PT,Ronco C,Goldstein SL,ADQI 16 workgroup.

更新日期：2018-02-01 00:00:00