Efficacy and safety of histamine-2 receptor antagonists.

Abstract:

IMPORTANCE:Histamine-2 receptor antagonists (H2RAs) are frequently used in the treatment of gastroesophageal reflux disease (GERD) in children; however, their efficacy and safety is questionable. OBJECTIVE:To systematically review the literature to assess the efficacy and safety of H2RAs in pediatric GERD. EVIDENCE REVIEW:PubMed, EMBASE, and the Cochrane database were searched for randomized clinical trials investigating the efficacy and safety of H2RAs in pediatric GERD. Two reviewers independently extracted data from the included articles. The quality of the evidence was assessed using the Grades of Recommendations, Assessment, Development, and Evaluation approach. When possible, infants and children were analyzed separately. FINDINGS:Eight studies with a total of 276 children (0-15 years of age) were included. Compared with the placebo, H2RAs were more effective in the reduction of symptoms in terms of histologic healing and increasing gastric pH and had a larger overall treatment effect. In infants, H2RAs were only more effective in terms of histologic healing. Comparing H2RAs with antacids, H2RAs were more effective in symptom reduction in only 1 study. H2RAs compared with proton pump inhibitors were not significantly different in any of the outcome measures. For safety analysis, data were not reported in a quantitative manner and for all outcomes, the quality of evidence was very low. CONCLUSIONS AND RELEVANCE:Evidence to support the efficacy and safety of H2RAs in infants and children is limited and of poor quality. Well-designed placebo-controlled trials are needed before thorough conclusions can be drawn.

journal_name

JAMA Pediatr

journal_title

JAMA pediatrics

authors

van der Pol R,Langendam M,Benninga M,van Wijk M,Tabbers M

doi

10.1001/jamapediatrics.2014.1273

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

947-54

issue

10

eissn

2168-6203

issn

2168-6211

pii

1897084

journal_volume

168

pub_type

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