Abstract：
BACKGROUND:Children with hepatoblastoma routinely undergo repetitive surveillance imaging, with CT scans for several years after therapy, increasing the risk of radiation-induced cancer. OBJECTIVE:The purpose of this study was to determine the utility of surveillance CT scans compared to serum alpha-fetoprotein (AFP) levels for the detection of hepatoblastoma relapse. MATERIALS AND METHODS:This was a retrospective study of all children diagnosed with AFP-positive hepatoblastoma from 2001 to 2011 at a single institution. RESULTS:Twenty-six children with hepatoblastoma were identified, with a mean age at diagnosis of 2 years 4 months (range 3 months to 11 years). Mean AFP level at diagnosis was 132,732 ng/ml (range 172.8-572,613 ng/ml). Five of the 26 children had hepatoblastoma relapse. A total of 105 imaging exams were performed following completion of therapy; 88 (84%) CT, 8 (8%) MRI, 5 (5%) US and 4 (4%) FDG PET/CT exams. A total of 288 alpha-fetoprotein levels were drawn, with a mean of 11 per child. The AFP level was elevated in all recurrences and no relapses were detected by imaging before AFP elevation. Two false-positive AFP levels and 15 false-positive imaging exams were detected. AFP elevation was found to be significantly more specific than PET/CT and CT imaging at detecting relapse. CONCLUSION:We recommend using serial serum AFP levels as the preferred method of surveillance in children with AFP-positive hepatoblastoma, reserving imaging for the early postoperative period, for children at high risk of relapse, and for determination of the anatomical site of clinically suspected recurrence. Given the small size of this preliminary study, validation in a larger patient population is warranted.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Rojas Y,Guillerman RP,Zhang W,Vasudevan SA,Nuchtern JG,Thompson PAdoi
10.1007/s00247-014-3000-6subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1275-80issue
10eissn
0301-0449issn
1432-1998journal_volume
44pub_type
杂志文章abstract：:A 10-year old, mentally and physically normally developed girl complained of back pain following an accident. Radiological findings revealed an inhomogeneous, coarse osteosclerosis along the endplates and posterior parts of the ovoid shaped vertebral bodies, in the proximal and distal femora-, proximal humeri and tibi...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02387669
更新日期：1989-01-01 00:00:00
abstract：:The Computed Tomography (CT) appearance of a pelvic haemangioma involving the rectum in two children, one with the Vater association and one with Klippel-Trenaunay syndrome, is described. Both cases complained of painless rectal bleeding and the diagnosis was suggested by the presence of pelvic phleboliths on the plai...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02387639
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:There are many controversies surrounding the effectiveness of endoscopic treatment of vesicouretheral reflux (VUR) in children, thus it is of highest priority to analyze factors influencing the outcome of therapy and to search for new methods that would increase the success rate and reduce the number of rein...
journal_title：Pediatric radiology
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02386819
更新日期：1986-01-01 00:00:00
abstract：:Imaging plays a major role in the diagnostic work-up of children with hepatobiliary or pancreatic diseases. It consists mainly of US, CT and MRI, with US and MRI being the preferred imaging modalities because of the lack of ionizing radiation. In this review the technique of US, CT and MRI in children will be addresse...
journal_title：Pediatric radiology
pub_type： 杂志文章,评审
doi：10.1007/s00247-010-1858-5
更新日期：2011-01-01 00:00:00
abstract：:The anatomical anomalies that characterize septo-optic-dysplasia (deMorsier Syndrome) are variable and often subtle. We report imaging studies of nine patients with septo-optic-dysplasia which provide radiologic and ultrasonographic clues to this disorder. In addition, we propose that cerebral schizencephaly may be a ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02388642
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:The Haller index is an accepted CT method for evaluating thoracic dimensions in patients with pectus excavatum. The purpose of this study is to establish age- and gender-related norms for the Haller index in childhood. MATERIALS AND METHODS:We retrospectively reviewed 574 consecutive chest CT examinations (M=2...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-003-1116-1
更新日期：2004-04-01 00:00:00
abstract：:Hemangiopericytoma (HP) is a rare vascular tumor that usually occurs in adults, but 10% occur in children. Tumors occurring in the first year of life are even more rare and are referred to as infantile hemangiopericytoma. In this article, we report the imaging, operative, and pathological findings in a patient with an...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470050738
更新日期：2000-04-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF00973956
更新日期：1976-02-13 00:00:00
abstract：:Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old a...
journal_title：Pediatric radiology
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doi：10.1007/s00247-007-0661-4
更新日期：2008-03-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470050728
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Newborns and small infants have shallow breathing. OBJECTIVE:To suggest criteria for when respiratory gating is necessary during cardiac MRI in newborns and infants. MATERIALS AND METHODS:One-hundred ten data sets of newborns and infants with (n = 92, mean age: 1.9 ± 1.7 [SD] years) and without (n = 18, me...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-015-3346-4
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Awareness and preparedness to handle sedation, analgesia, and contrast-media complications are key in the daily radiology practice. OBJECTIVE:The purpose is to create a computerized simulator (PC-Windows-based) that uses a graphical interface to reproduce critical incidents in pediatric and adult patients u...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470050744
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Unusual acute symptomatic and reversible early-delayed leukoencephalopathy has been reported to be induced by methotrexate (MTX). OBJECTIVE:We aimed to identify the occurrence of such atypical MTX neurotoxicity in children and document its MR presentation. MATERIALS AND METHODS:We retrospectively reviewed ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-005-0015-z
更新日期：2006-03-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470000331
更新日期：2000-11-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-018-4137-5
更新日期：2018-08-01 00:00:00
abstract：:An otherwise healthy 11-month-old boy presented with bilateral abdominal masses. Imaging findings, differential diagnosis, histological findings, and pertinent discussion are presented. ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470050197
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Hepatic involvement is frequent in patients with cystic fibrosis (CF), with focal biliary cirrhosis being the pathognomonic hepatic manifestation. In around one-quarter of CF patients, it results in CF-associated liver disease (CFLD). This occurs as a relatively early complication with the majority of patien...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-009-1531-z
更新日期：2010-07-01 00:00:00
abstract：:This article is the first of a two-part series on intracranial calcification in childhood. Intracranial calcification can be either physiological or pathological. Physiological intracranial calcification is not an expected neuroimaging finding in the neonatal or infantile period but occurs, as children grow older, in ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-020-04721-1
更新日期：2020-09-01 00:00:00
abstract：:Two cases of neonatal spontaneous rupture of the esophagus are described, one of which is associated with a duodenal stenosis. Seventeen cases have been reported. They present clinically with non-specific signs of respiratory insufficiency and radiologically by a right-sided hydropneumothorax. Esophageal opacification...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02386871
更新日期：1986-01-01 00:00:00
abstract：:Long-term imaging and clinical findings are reported in six children whose polycystic kidney disease was detected in infancy or early childhood. Over time (2 years to 20 years) all patients developed portal hypertension from hepatic fibrosis, a problem primarily noted in recessive pattern polycystic kidney disease. Mi...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02387555
更新日期：1988-01-01 00:00:00
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journal_title：Pediatric radiology
pub_type： 杂志文章,评审
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更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:The aberrant cervical thymus is an uncommon entity to be considered in the differential diagnosis of neck masses in children, so a preoperative diagnosis has rarely been made. OBJECTIVE:The purpose of this study was to assess the ultrasound features of aberrant cervical thymus and determine if recognition o...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s002470100468
更新日期：2001-07-01 00:00:00
abstract：:The diagnosis of Wilms' tumor is usually made by excretory urography after the patient presents with an abdominal mass. A diagnosis prior to the appearance of an obvious mass might result in an improved cure rate and less morbid therapy. The three cases described illustrate the difficulty in making an earlier diagnosi...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF01000118
更新日期：1975-03-20 00:00:00
abstract：:The neurosonograms of fifty-eight patients treated over a four-year period with ECMO support were retrospectively reviewed for analysis of changes in interhemispheric (IHF) width while on ECMO. To correlate these measurements with patterns of development of total body edema as reflected by chest wall thickening on por...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02010805
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Balloon dilatation of the oesophagus in children has been performed predominantly for treating strictures, which are the result of primary repair of oesophageal atresia, interposition surgery or restrictive Nissen's fundoplication. Reports of the use of this technique for alternative causes of stricture are ...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-003-1011-9
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:New developments in processing of digital radiographs (DR), including multi-frequency processing (MFP), allow optimization of image quality and radiation dose. This is particularly promising in children as they are believed to be more sensitive to ionizing radiation than adults. OBJECTIVE:To examine whether...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-012-2385-3
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Recent reports have highlighted the lifetime risk of malignancy from using ionizing radiation in pediatric imaging. Computed tomography (CT), which uses ionizing radiation, is employed extensively for neonatal brain imaging of term infants. Magnetic resonance (MR) provides an alternative that does not use io...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/s00247-003-0933-6
更新日期：2003-07-01 00:00:00
abstract：:The detailed radiographic features of triploidy, a fatal congenital disorder with 69 chromosomes, have not previously been reported. Radiographs of ten liveborn infants with chromosomally confirmed triploidy showed six findings highly suggestive of this diagnosis: harlequin orbits, small anterior fontanelle, gracile r...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02386842
更新日期：1989-01-01 00:00:00
abstract：:The relationship between image noise and radiation dose was investigated in computed tomography (CT) images of a pediatric abdomen phantom. A protocol which provided a minimum absorbed dose consistent with acceptable image noise criteria was determined for a fourth generation CT scanner. It was found that pediatric ab...
journal_title：Pediatric radiology
pub_type： 杂志文章
doi：10.1007/BF02387506
更新日期：1986-01-01 00:00:00
