Abstract:
BACKGROUND:Hepatic involvement is frequent in patients with cystic fibrosis (CF), with focal biliary cirrhosis being the pathognomonic hepatic manifestation. In around one-quarter of CF patients, it results in CF-associated liver disease (CFLD). This occurs as a relatively early complication with the majority of patients presenting in childhood or their early teens. However, a normal US does not preclude significant liver fibrosis and liver biopsy is an invasive procedure that is hampered by potential sampling errors. Transient elastography (TE) (Fibroscan) is a non-invasive, user-friendly and quick technique that provides an objective and reproducible measure of liver stiffness. This is accomplished with a device using an US probe mounted in the axis of a vibrator. Vibrations are transmitted by the transducer, inducing an electronic shear wave that propagates through the underlying tissue. OBJECTIVES:We aimed to prospectively compare TE and transabdominal US scanning in children and adults attending a CF clinic. MATERIALS AND METHODS:A total of 134 consecutive patients with documented CF were prospectively studied. In each case, transient elastography measurement was performed immediately after the routine annual US evaluation of the liver. Sonographic appearance of the liver was classified from 1 to 5. Ten validated TE measurements were performed in each patient with the result expressed in kilopascals (kPa). The median value was considered representative of the elastic modulus of the liver. RESULTS:Measurements were performed in 59 CF adults, 75 CF children and 31 control children. There was no relationship between age and liver stiffness in either the control group or CF patients. Elasticity values of controls, CF pancreatic sufficient (PS) patients and pancreatic insufficient (PI) CF patients with a US score <3 were comparable and significantly lower than in CF patients with a US score > or = 3 (all PI) (P < 0.002). Median elasticity in CF patients was significantly higher in males (4.7 kPa) than in females (3.9 kPa) (P = 0.0013). CONCLUSION:Considering the limitations of US and the low risk-benefit rate of liver biopsy in most CF patients, this preliminary study suggests that TE is an attractive non-invasive way to assess and follow-up liver disease in these patients.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Menten R,Leonard A,Clapuyt P,Vincke P,Nicolae AC,Lebecque Pdoi
10.1007/s00247-009-1531-zsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
1231-5issue
7eissn
0301-0449issn
1432-1998journal_volume
40pub_type
杂志文章abstract::Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging f...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-015-3326-8
更新日期:2015-09-01 00:00:00
abstract::We report a rare case of cystic metastases to the liver from a peripheral primitive neuroectodermal tumour in a child. Ultrasound and CT appearances are described with a discussion on the histological findings and the differential diagnosis. ...
journal_title:Pediatric radiology
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abstract::There are few descriptions of the magnetic resonance (MR) appearance of hyperfunctioning adrenocortical tumours, particularly those occurring in childhood. We studied five patients, two girls and three boys, aged 6-14.3 years, presenting with clinical syndromes of adrenocortical hyperfunction. The diagnoses were Cushi...
journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-03-01 00:00:00
abstract::The mainstay of imaging of gastrointestinal (GI) pathology in infants has always been and still is the plain radiograph of the abdomen and conventional contrast studies. In this review emphasis is placed on the situations where there are new imaging strategies and alternative modalities of imaging, including US, CT, M...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-010-1582-1
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abstract::As the need for accurate diagnostic imaging often continues throughout a cancer survivor's life, imaging methods with the least toxicity must be used so as to provide needed information without contributing to long-term sequelae that might compound toxicities inherent with the primary disease and its treatment. In thi...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
abstract::Isolated, well-differentiated ectopic cerebellar tissue is extremely rare, with only eight cases in the literature. We describe a unique case of histopathologically proven ectopic cerebellar tissue presenting as a discrete extra-axial mass in the posterior cranial fossa. We describe the clinical, CT and MRI findings, ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-012-2411-5
更新日期:2012-11-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-007-0548-4
更新日期:2007-09-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:Pediatric radiology
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更新日期:2004-04-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Peripherally inserted central catheter (PICC) is among the most common procedures performed in children in the hospital setting. PICC insertion can be simplified with the use of a sheathed needle as an alternative to the modified Seldinger technique. OBJECTIVE:To retrospectively evaluate PICC placement for ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-016-3629-4
更新日期:2016-09-01 00:00:00
abstract::Antenatal detection of mesoblastic nephroma by US is possible. Reviewing the literature, we found 19 previously reported cases, only 1 of which underwent prenatal MRI. We present a further case diagnosed by US and confirmed with MRI. The imaging findings and differential diagnoses are discussed. Early and correct dete...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050033
更新日期:2000-03-01 00:00:00
abstract::Perigraft seroma is a rare complication of synthetic vascular grafts. We describe a new sign observed in two children who underwent computed tomography of the chest for further evaluation of seromas complicating modified Blalock-Taussig procedures in which a polytetrafluoroethylene graft was used. In both patients con...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050141
更新日期:1997-04-01 00:00:00
abstract::Treatment-related neurotoxicity is a potentially life-threatening clinical condition that can represent a diagnostic challenge. Differentiating diagnoses between therapy-associated brain injury and recurrent disease can be difficult, and the immediate recognition of neurotoxicity is crucial to providing correct therap...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-016-3750-4
更新日期:2017-05-01 00:00:00
abstract::Three children with adult cadaveric bone allografts for the treatment of bone malignancies are presented. Follow-up magnetic resonance (MR) imaging demonstrated decreased signal on T1-weighted imaging and increased signal on T2-weighted imaging in the allograft without clinical evidence of recurrent disease. These sig...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02015006
更新日期:1994-01-01 00:00:00
abstract::Imaging is a crucial part of the evaluation of children with primary liver malignancies. In addition to staging the intrahepatic extent of the tumour, the 2005 revision of the PRETEXT system specifies certain criteria for assessment of extrahepatic disease. This article reviews the imaging findings of two of these cri...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-007-0513-2
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Fetal MRI can be performed in the second and third trimesters. During this time, the fetal brain undergoes profound structural changes. Interpretation of appropriate development might require comparison with normal age-based models. Consultation of a hard-copy atlas is limited by the inability to compare mul...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1411-6
更新日期:2010-02-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010815
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Whole-body MRI is used for staging paediatric Hodgkin lymphoma, commonly using size thresholds, which fail to detect disease in normal-size lymph nodes. OBJECTIVE:To investigate quantitative whole-body MRI metrics for nodal characterisation. MATERIALS AND METHODS:Thirty-seven children with Hodgkin lymphoma...
journal_title:Pediatric radiology
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更新日期:2019-09-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00975684
更新日期:1978-06-19 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
abstract::A pseudocyst developed in a child following acute pancreatitis and spontaneously drained into the common bile duct, a rare occurrence previously described only in adults. The imaging findings are similar to those of a choledochal cyst; serial sonograms enabled diagnosis by documenting evolution of the lesion and shoul...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01625964
更新日期:1983-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388368
更新日期:1985-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-002-0720-9
更新日期:2002-09-01 00:00:00
abstract::Congenital cardiac malformations (CCM) are the commonest congenital anomalies. Using ultrasonography (US), the incidence of CCM in a selected group of fetuses and the impact of CCM on perinatal and postnatal care was evaluated. The indication for fetal echocardiography (F-ECHO) in 152 pregnancies was a positive family...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02387894
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Osteomyelitis is a challenging diagnosis for clinicians, particularly in very young children. At our institution, the magnetic resonance imaging (MRI) protocol in suspected osteomyelitis for children 5 years of age or younger includes a large field of imaging regardless of the clinical site of concern. OBJE...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4317-3
更新日期:2019-03-01 00:00:00
abstract::Ultrasound scans of 18 children with primary hepatic tumours were reviewed to assess the accuracy of ultrasound in determining hepatic origin, extent, resectability, and histology. Using basic landmarks, ultrasound correctly predicted extent and resectability in 72% of patients. Accuracy would be increased by more det...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388402
更新日期:1988-01-01 00:00:00