Abstract:
OBJECTIVE:To evaluate the perioperative, postoperative and functional outcomes of robot-assisted partial nephrectomy (RAPN) for renal tumours with high surgical complexity at a large volume centre. PATIENTS AND METHODS:Perioperative and functional outcomes of RAPNs for renal tumours with a Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score of ≥10 performed at our institution between September 2006 and December 2012 were collected in a prospectively maintained database and analysed. Surgical complications were graded according to the Clavien-Dindo classification. Serum creatinine and estimated glomerular filtration rate (eGFR) were assessed at the third postoperative day and 3-6 months after RAPN. RESULTS:In all, 44 RAPNs for renal tumours with PADUA scores of ≥10 were included in the analysis; 23 tumours (52.3%) were cT1b. The median (interquartile range; range) operative time, estimated blood loss and warm ischaemia time (WIT) were 120 (94, 132; 60-230) min, 150 (80, 200; 25-1200) mL and 16 (13.8, 18; 5-35) min, respectively. Two intraoperative complications occurred (4.5%): one inferior vena caval injury and one bleed from the renal bed, which were both managed robotically. There were postoperative complications in 10 patients (22.7%), of whom four (9.1%) were high Clavien grade, including two bleeds that required percutaneous embolisation, one urinoma that resolved with ureteric stenting and one bowel occlusion managed with laparoscopic adhesiolysis. Two patients (4.5%) had positive surgical margins (PSMs) and were followed expectantly with no radiological recurrence at a mean follow-up of 23 months. The mean serum creatinine levels were significantly increased after surgery (121.1 vs 89.3 μmol/L; P = 0.001), but decreased over time, with no significant differences from the preoperative values at the 6-month follow-up (96.4 vs 89.3 μmol/L; P = 0.09). The same trend was seen for eGFR. CONCLUSION:In experienced hands RAPN for renal tumours with a PADUA score of ≥10 is feasible with short WIT, acceptable major complication rate and good long-term renal functional outcomes. A slightly higher risk of PSMs can be expected due to the high surgical complexity of these lesions. The robotic technology allows a safe expansion of the indications of minimally invasive PN to anatomically very challenging renal lesions in referral centres.
journal_name
BJU Intjournal_title
BJU internationalauthors
Volpe A,Garrou D,Amparore D,De Naeyer G,Porpiglia F,Ficarra V,Mottrie Adoi
10.1111/bju.12751subject
Has Abstractpub_date
2014-12-01 00:00:00pages
903-9issue
6eissn
1464-4096issn
1464-410Xjournal_volume
114pub_type
杂志文章abstract:OBJECTIVE:To evaluate a group of young women undergoing complex vaginoplasty, which may be defined as where there has already been previous complex pelvic surgery and the patient is unsuitable for conservative treatment or minor surgical revision. PATIENTS AND METHODS:All patients who had undergone a complex vaginopla...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05522.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS:From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance ...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1046/j.1464-410x.2003.04413.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:To examine patterns of care among women with urogenital fistula treated in the English National Health Service (NHS) between 2000 and 2009. To assess whether failure of repair was associated with hospital or surgeon workload. PATIENTS AND METHODS:We conducted a retrospective cohort study using data from Hos...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11483.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To summarize the urological procedures recorded in Hospital Episodes Statistics (HES, 1998-99) and to examine the accuracy of coding and HES. MATERIALS AND METHODS:Data on the 10 commonest urological procedures from the Department of Health website (www.doh.gov.uk/hes) were extracted, summarized and presente...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02833.x
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To examine the effects of castration and continuous gonadotrophin releasing-hormone (GnRH) agonist and antagonist therapy on the expression of GnRH-receptors type I (GnRH-RI) in rat ventral prostate (VP) and pituitary tissue, and to compare the effects on prostate morphology. MATERIAL AND METHODS:Mature Spra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03054.x
更新日期:2003-02-01 00:00:00
abstract::OBJECTIVE To describe the rationale and design of the Bladder Cancer Prognosis Programme (BCPP), and to demonstrate the capability of this design. METHODS There is a need to understand the determinants of bladder cancer to help reduce recurrence, progression, morbidity, mortality and related costs. We previously showe...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08849.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria. PATIENTS AND METHODS:We conducted a retrospective single-centre analysis of 247 consecutive patients. The recruitment period was January 2001 to October 2015. A total of 328 inflata...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14027
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological asses...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09442.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02981.x
更新日期:2002-10-01 00:00:00
abstract::Patients with metastatic bone disease often have severe bone pain and debilitating skeletal complications. Zoledronic acid is the only bisphosphonate shown to be safe and effective in reducing skeletal-related events (SREs), including pathological fractures, spinal cord compression, and radiation or surgery to bone in...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2005.05740.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07046.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14894
更新日期:2019-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05576.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To evaluate among radical prostatectomy (RP) patients at high-risk of recurrence whether the timing of postoperative radiation therapy (RT) (adjuvant, early salvage with detectable post-RP prostate-specific antigen [PSA], or 'late' salvage with a PSA level of >1.0 ng/mL) is significantly associated with overa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13043
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the conservative management of encrusted pyelitis (EP), an infectious disease caused by urea-splitting micro-organisms (Corynebacterium group D2 being the most common), and characterized by stone encrustation of the collecting system. PATIENTS AND METHODS:Four patients (aged 17-62 years) with EP ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00156.x
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To study a novel penile reinnervation technique using four sural nerve grafts and end-to-side neurorraphies connecting bilaterally the femoral nerve and the cavernous corpus and the femoral nerve and the dorsal penile nerves. PATIENTS AND METHODS:Ten patients (mean [± sd; range] age 60.3 [± 4.8; 54-68] years...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13772
更新日期:2017-06-01 00:00:00
abstract::Lower urinary tract symptoms (LUTS), benign prostatic obstruction (BPO), and the overactive bladder have increasing prevalence with age in both men and women (with the obvious exception). The question is, are they interrelated or independently related to age? The specific issue is whether BPO causes the overactive bla...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410x.2000.tb16953.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:• To investigate the role of c-kit-positive interstitial cells (ICCs) in mediating muscarinic receptor-induced phasic contractions of isolated bladder strips from streptozotocin(STZ)-induced diabetic rats and to confirm the expression and location of ICCs in the rat bladder. MATERIALS AND METHODS:• Bladders ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09507.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To assess the rate of prostate-specific antigen (PSA) testing for prostate cancer in general practice in asymptomatic and symptomatic patients. SUBJECTS AND METHODS:The cross-sectional study took place in England and Wales, was population-based and covered 469 159 men aged 45-84 years. Pathology data on PSA ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-4096.2004.04832.x
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To assess the durability of holmium laser enucleation of prostate in comparison to transurethral resection of the prostate (TURP). PATIENTS AND METHODS:Patients were enrolled in the present study between June 1997 and December 2000 and followed per protocol. All patients were urodynamically obstructed with a...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10359.x
更新日期:2012-02-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Percutaneous renal cryoablation is a safe and effective treatment for patients with small renal masses, who are poor surgical candidates. Oncological outcomes from previous percutaneous ablation studies are difficult to interpret because of the large ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11230.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To investigate the experience of patients living with renal calculi via a qualitative methodology, aiming to develop and validate a disease-specific patient-reported outcome measure (PROM) for renal stones, the Cambridge Renal Stone PROM (CReSP). PATIENTS, SUBJECTS AND METHODS:Patients with radiologically c...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14873
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. What's known on the subject? and What does the study add? The indications and timing of native nephrectomy in patients with autosomal dominant polycystic kidney disease (ADPKD) is controversial, especially for those undergoing renal transplantation. P...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09938.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To highlight the existence of Schistosoma haematobium in certain ethnic minority groups in Britain and in English citizens who have recently visited Africa and the Middle East, so that general practitioners and paediatric nephrologists/urologists are aware of its occurrence and consider it among the different...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00477.x
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence of bone fractures in patients receiving luteinizing hormone-releasing hormone agonists (LHRH-a) for prostate cancer (in whom a continued low testosterone level after the long-term administration of these drugs reduces bone mineral density), and thus determine the risk of secondary...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00774.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To determine the level of malondialdehyde (MDA), an indirect indicator of lipid peroxidation-induced injury by reactive oxygen species, in testicular biopsy specimens from infertile patients with and without varicocele. PATIENTS AND METHODS:Levels of MDA were measured in the testicular biopsy specimens from ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00755.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To report our experience of using laparoscopy for the accurate location and simultaneous removal of small dysplastic kidneys with ectopic ureteric insertion causing urinary incontinence and that were not detected by conventional imaging modalities. PATIENTS AND METHODS:Seven girls (mean age 7.9 years, range ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00162.x
更新日期:1999-08-01 00:00:00
abstract::OBJECTIVE • To evaluate a novel technique to lower positive surgical margin rates while preserving as much of the neurovascular bundles as possible during nerve-sparing robotic prostatectomy. MATERIALS AND METHODS • In situ intraoperative frozen section (IFS) was performed during robotic-assisted laparoscopic prostate...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09595.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between symptom severity and patient perceptions in patients with overactive bladder (OAB), as estimated by OAB Symptom Score (OABSS) and patient-reported outcome measures, respectively. PATIENTS AND METHODS:Post-hoc analyses were conducted on the existing data from patients with O...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08498.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:We evaluated survival outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for clinical T2 renal masses (cT2RM) controlling for R.E.N.A.L. nephrometry score. PATIENTS AND METHODS:A two-centre study comprised of 202 patients with cT2RM who underwent RN (122) or PN (80) between July 2002 and June ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12580
更新日期:2014-11-01 00:00:00