A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).

abstract：:T cell clones of C57BL/6 origin which recognize porcine lactate dehydrogenase B (LDH-BP) together with the Ab molecule were characterized in terms of fine specificity for both LDH-B and self-major histocompatibility complex determinants. Using antigen-presenting cells from the Ab-mutant strain B6.C-H-2bm12 (bm12), thr...

journal_title：European journal of immunology

authors： Nagy ZA,Servis C,Walden P,Klein J,Goldberg E

更新日期：1985-08-01 00:00:00

abstract：:APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

journal_title：European journal of immunology

authors： Mariani SM,Matiba B,Armandola EA,Krammer PH

更新日期：1994-12-01 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in the signaling of a number of cellular responses including activation of T cells. In the present report we have evaluated the effect of increased cAMP levels on PKC activation after stimulation of two distinct receptor systems on normal human T cells. PKC substrate phosphor...

journal_title：European journal of immunology

authors： Friedrich B,Cantrell DA,Gullberg M

更新日期：1989-06-01 00:00:00

abstract：:Rat CD4+ T cells are divided phenotypically by the anti-CD45RC monoclonal antibody OX22 into subsets with contrasting functions. Stimulation of T cells in vitro is known to induce a change in isoform from CD45RC+ to CD45RC-. We have investigated the in vitro conditions which promote a switch in isoform in the opposite...

journal_title：European journal of immunology

authors： Sarawar SR,Sparshott SM,Sutton P,Yang CP,Hutchinson IV,Bell EB

更新日期：1993-01-01 00:00:00

abstract：:In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

journal_title：European journal of immunology

authors： Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

更新日期：1991-08-01 00:00:00

abstract：:Aging is accompanied by altered immunity, resulting in a variable state of poorly understood immunodeficiency. While both the numbers and the functionality of naïve T cells are decreased by aging, the impact of these changes upon immune defense against bacterial pathogens in vivo remains understudied. Using a model of...

journal_title：European journal of immunology

authors： Smithey MJ,Renkema KR,Rudd BD,Nikolich-Žugich J

更新日期：2011-05-01 00:00:00

abstract：:The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have i...

journal_title：European journal of immunology

authors： Brown JA,Greenwald RJ,Scott S,Schweitzer AN,Satoskar AR,Chung C,Schopf LR,van der Woude D,Sypek JP,Sharpe AH

更新日期：2002-06-01 00:00:00

abstract：:In this study, we examined which cell population contributes to IL-5 production by Peyer's patch (PP) cells. Thy1.2(-) fraction of PP cells, but not those of splenocytes, secreted IL-5 in response to IL-2. We found that CD3epsilon(-)IL-2Ralpha(+) cells purified from the Thy1.2(-)B220(-) fraction of PP cells secreted I...

journal_title：European journal of immunology

authors： Kuraoka M,Hashiguchi M,Hachimura S,Kaminogawa S

更新日期：2004-07-01 00:00:00

abstract：:We have previously demonstrated that mycobacterial lipoproteins engage TLR2 on human CD4(+) T cells and upregulate TCR-triggered IFN-γ secretion and cell proliferation in vitro. Here we examined the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection ag...

journal_title：European journal of immunology

authors： Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE

更新日期：2014-05-01 00:00:00

abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

journal_title：European journal of immunology

authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

更新日期：1999-07-01 00:00:00

abstract：:We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...

journal_title：European journal of immunology

authors： Helgason CD,Prendergast JA,Berke G,Bleackley RC

更新日期：1992-12-01 00:00:00

abstract：:The glycosylphosphatidylinositol (GPI)-anchored CD59 protein (human protectin) protects cells against complement-induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical signals transduced by CD59 and addressed its role in regard to the CD3-mediated si...

journal_title：European journal of immunology

authors： Deckert M,Ticchioni M,Mari B,Mary D,Bernard A

更新日期：1995-07-01 00:00:00

abstract：:We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...

journal_title：European journal of immunology

authors： Kirberg J,Bruno L,von Boehmer H

更新日期：1993-08-01 00:00:00

abstract：:Mice carrying the lpr gene, SCG and MRL-lpr/lpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of T cell receptor (TCR) (and CD3) and the phenotype of interle...

journal_title：European journal of immunology

authors： Yamagiwa S,Kuwano Y,Hasegawa K,Sato K,Ohtsuka K,Iiai T,Tomiyama K,Watanabe H,Sugahara S,Seki S,Asakura H,Abo T

更新日期：1996-07-01 00:00:00

abstract：:Alymphoplasia mice (aly/aly) have been shown to be deficient for a nuclear factor-kappaB-inducing kinase involved in signal transduction of lymphotoxin beta receptor (LT-betaR) and of CD40, resulting in structural defects of secondary lymphoid organs and highly increased susceptibility to viral infections. We analyzed...

journal_title：European journal of immunology

authors： Karrer U,Althage A,Odermatt B,Hengartner H,Zinkernagel RM

更新日期：2000-10-01 00:00:00

abstract：:The major role of cells of the dendritic family in immunity and tolerance has been amply documented. Since their discovery in 1973, these cells have gained increasing interest from immunologists, as they are able to detect infectious agents, migrate to secondary lymphoid tissue, and prime naive T lymphocytes, thereby ...

journal_title：European journal of immunology

authors： Hespel C,Moser M

更新日期：2012-10-01 00:00:00

abstract：:The immunologic mechanisms that protect the fetus from rejection were the subject of numerous investigations. Reports showing the uterus as a favorable site of implantation focused our attention to the decidua which is the maternal tissue intimately attached to fetal structures. Explants of human decidua were cultured...

journal_title：European journal of immunology

authors： Golander A,Zakuth V,Shechter Y,Spirer Z

更新日期：1981-10-01 00:00:00

abstract：:T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differ...

journal_title：European journal of immunology

authors： Gehre N,Nusser A,von Muenchow L,Tussiwand R,Engdahl C,Capoferri G,Bosco N,Ceredig R,Rolink AG

更新日期：2015-03-01 00:00:00

abstract：:B cells in rabbit preferentially utilize the 3'-most VH gene, VH1, in VDJ genes. To determine whether the preferential utilization of VH1 results from preferential rearrangement, we examined VH gene usage in nonproductive VDJ gene rearrangements, genes that would not be influenced by antigen selection. Since nonproduc...

journal_title：European journal of immunology

authors： Tunyaplin C,Knight KL

更新日期：1995-09-01 00:00:00

abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

journal_title：European journal of immunology

authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

更新日期：1997-12-01 00:00:00

abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

journal_title：European journal of immunology

authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

更新日期：2005-06-01 00:00:00

abstract：:The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...

journal_title：European journal of immunology

authors： Takeuchi O

更新日期：2015-05-01 00:00:00

abstract：:Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses of either error-prone...

journal_title：European journal of immunology

authors： Ford JE,McHeyzer-Williams MG,Lieber MR

更新日期：1994-08-01 00:00:00

abstract：:Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mat...

journal_title：European journal of immunology

authors： Manfredi AA,Heltai S,Rovere P,Sciorati C,Paolucci C,Galati G,Rugarli C,Vaiani R,Clementi E,Ferrarini M

更新日期：1998-06-01 00:00:00

abstract：:After incorporation of 14C-labeled amino acids and/or of [3H]fucose during in vitro culture of the Thy-1.1-bearing, Fc receptor-positive T lymphoma, L-5187-Y, attempts were made to purify the Fc binding structure(s). Following solubilization of a crude membrane pellet using sodium deoxycholate, the 110 000 x g superna...

journal_title：European journal of immunology

authors： Frade R,Kourilsky FM

更新日期：1977-09-01 00:00:00

abstract：:The TNF member LIGHT also known as TL4 or TNFSF14) can play a major role in cancer control via its two receptors; it induces tumor cell death through lymphotoxin-beta receptor (LT-betaR) and ligation to the herpes virus entry mediator (HVEM) amplifies the immune response. By studying the effect of LIGHT in the transcr...

journal_title：European journal of immunology

authors： Pasero C,Barbarat B,Just-Landi S,Bernard A,Aurran-Schleinitz T,Rey J,Eldering E,Truneh A,Costello RT,Olive D

更新日期：2009-09-01 00:00:00

abstract：:The most common reason for heart failure in young adults is dilated cardiomyopathy often resulting from myocarditis. Clinical studies and animal models provide evidence that an autoimmune response against heart myosin is the underlying reason for the disease. IL-12 has been suggested to play a key role in development ...

journal_title：European journal of immunology

authors： Sonderegger I,Röhn TA,Kurrer MO,Iezzi G,Zou Y,Kastelein RA,Bachmann MF,Kopf M

更新日期：2006-11-01 00:00:00

abstract：:Cross-linking of surface Ig receptors (sIg) by mitogenic forms of anti-Ig antibodies (e.g. F(ab')2 fragments of rabbit anti-Ig) causes the rapid, and prolonged breakdown of phosphatidylinositol 4,5-bisphosphate. This response involves an unidentified guanine nucleotide regulatory protein (termed Gp), which couples sIg...

journal_title：European journal of immunology

authors： Rigley KP,Harnett MM,Klaus GG

更新日期：1989-03-01 00:00:00

abstract：:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

journal_title：European journal of immunology

authors： Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

更新日期：1986-03-01 00:00:00

abstract：:Thymic nurse cells, cortical epithelial cells enclosing 20-200 lymphocytes, were prepared from mouse thymus by enzyme digestion and repetitive sedimentation. Individual nurse cells were then isolated free of any exogenous thymocytes by micromanipulation, and the endogeneous thymocytes released from inside the nurse ce...

journal_title：European journal of immunology

authors： Andrews P,Boyd RL,Shortman K

更新日期：1985-10-01 00:00:00