Abstract:
IMPORTANCE:Schnabel cavernous degeneration (SCD) has been observed in eyes with uveal melanoma (UM), but, to our knowledge, a definitive study establishing the association between SCD and UM has not been conducted. OBJECTIVE:To explore an association between SCD and UM. DESIGN, SETTING, AND PARTICIPANTS:A historical cohort analysis was performed using histologic slides and related clinical records of cases from the Collaborative Ocular Melanoma Study and Eye Pathology Laboratory at the University of Wisconsin, including 1985 UM eyes, 517 eye bank eyes, and 155 enucleated glaucomatous eyes. MAIN OUTCOMES AND MEASURES:The prevalence of SCD was calculated and compared between each group; subgroup analysis was also conducted of eyes with and without SCD for the prevalence of glaucoma. RESULTS:Schnabel cavernous degeneration was seen in 17 (0.9%) UM eyes, 9 (1.7%) eye bank eyes, and 2 (1.3%) enucleated glaucomatous eyes. No difference was detected between the prevalence of SCD in UM eyes and eye bank eyes (odds ratio [OR], 0.49; 95% CI, 0.22-1.10) or enucleated glaucomatous eyes (OR, 0.66; 95% CI, 0.15-2.89). Subgroup analysis, performed on 421 UM eyes, provided sufficient clinical information to definitively establish the presence or absence of glaucoma. Of the 95 (22.6%) eyes with glaucoma, 11 (11.6%) revealed histopathologic evidence of SCD. Compared with enucleated end-stage glaucoma eyes, this represents a 10-fold increase in SCD in UM eyes with glaucoma (OR, 10.10; 95% CI, 2.17-46.26). The prevalence of glaucoma in UM eyes with SCD, however, was respectively 7- and 15-fold higher than the prevalence of glaucoma in SCD-negative UM eyes (OR, 6.98; 95% CI, 2.51-19.43) and SCD-positive eye bank eyes (OR, 14.67; 95% CI, 1.46-146.97). CONCLUSIONS AND RELEVANCE:Although an association between SCD and UM was not confirmed, subgroup analysis did reveal an increased incidence of SCD in eyes with both UM and glaucoma. This suggests that the occurrence of glaucoma may increase the risk of SCD in eyes with UM.
journal_name
JAMA Ophthalmoljournal_title
JAMA ophthalmologyauthors
Kanavi MR,Azari AA,Potter HD,Lee V,Albert DMdoi
10.1001/jamaophthalmol.2013.8182subject
Has Abstractpub_date
2014-05-01 00:00:00pages
600-4issue
5eissn
2168-6165issn
2168-6173pii
1847501journal_volume
132pub_type
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journal_title:JAMA ophthalmology
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更新日期:2018-09-01 00:00:00
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journal_title:JAMA ophthalmology
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更新日期:2018-05-01 00:00:00
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journal_title:JAMA ophthalmology
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-08-01 00:00:00
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更新日期:2020-12-17 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-10-01 00:00:00
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更新日期:2018-12-01 00:00:00
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更新日期:2017-05-01 00:00:00
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更新日期:2018-11-01 00:00:00
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doi:10.1001/jamaophthalmol.2013.316
更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2015.2453
更新日期:2015-10-01 00:00:00
abstract:Importance:The US Food and Drug Administration's medical device regulatory pathway was initially conceived with hardware devices in mind. The emerging market for ophthalmic digital devices necessitates an evolution of this paradigm. Objectives:To facilitate innovation in ophthalmic digital health with attention to saf...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2019.1576
更新日期:2019-06-06 00:00:00
abstract:IMPORTANCE:The potential effect of treatments for diabetic macular edema (DME) on driving should be of value to patients and clinicians, such as ophthalmologists and other physicians, who treat patients with diabetes mellitus. OBJECTIVE:To determine the effect of ranibizumab on driving and patient-reported vision func...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamaophthalmol.2015.4636
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamaophthalmol.2017.0837
更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-02-01 00:00:00
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1001/jamaophthalmol.2014.376
更新日期:2014-07-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2018-06-01 00:00:00
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更新日期:2020-04-01 00:00:00
abstract:Importance:Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective:To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP co...
journal_title:JAMA ophthalmology
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更新日期:2021-01-14 00:00:00
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更新日期:2019-02-01 00:00:00