Anterior Segment Seeding in Eyes With Retinoblastoma Failing to Respond to Intraophthalmic Artery Chemotherapy.

abstract：Importance:There are limited published data on the phenotype of retinitis pigmentosa (RP) related to CNGB1 variants. These data are needed both for prognostic counseling of patients and for understanding potential treatment windows. Objective:To describe the detailed clinical and molecular genetic findings in a series...

journal_title：JAMA ophthalmology

authors： Hull S,Attanasio M,Arno G,Carss K,Robson AG,Thompson DA,Plagnol V,Michaelides M,Holder GE,Henderson RH,Raymond FL,Moore AT,Webster AR

更新日期：2017-02-01 00:00:00

abstract：IMPORTANCE:There is a major lack of randomized controlled clinical trials evaluating the efficacy of prismatic treatments for hemianopia. Evidence for their effectiveness is mostly based on anecdotal case reports and open-label evaluations without a control condition. OBJECTIVE:To evaluate the efficacy of real relativ...

journal_title：JAMA ophthalmology

authors： Bowers AR,Keeney K,Peli E

更新日期：2014-02-01 00:00:00

abstract：Importance:The number and size of guttae increase over time in Fuchs endothelial corneal dystrophy (FECD); however, the association between these physical parameters and disease pathogenesis is unclear. Objective:To determine the role of guttae in corneal endothelial cell function. Design, Settings, and Participants:...

journal_title：JAMA ophthalmology

authors： Kocaba V,Katikireddy KR,Gipson I,Price MO,Price FW,Jurkunas UV

更新日期：2018-08-01 00:00:00

abstract：Importance:Early detection of choroidal melanoma at a small tumor size is emphasized in the literature. However, there is little published information on the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis. Objective:To analyze outcomes of plaque radiotherapy for small chor...

journal_title：JAMA ophthalmology

authors： Shields CL,Sioufi K,Srinivasan A,Di Nicola M,Masoomian B,Barna LE,Bekerman VP,Say EAT,Mashayekhi A,Emrich J,Komarnicky L,Shields JA

更新日期：2018-12-01 00:00:00

abstract：IMPORTANCE:The effect of glaucoma on nonglaucomatous medical conditions and resultant secondary health care costs is not well understood. OBJECTIVE:To assess self-reported medical conditions, the use of medical services, and total health care costs among Medicare beneficiaries with glaucoma. DESIGN, SETTING, AND PART...

journal_title：JAMA ophthalmology

authors： Prager AJ,Liebmann JM,Cioffi GA,Blumberg DM

更新日期：2016-04-01 00:00:00

abstract：Importance:Some eyes with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent intravitreal anti-vascular endothelial growth factor (VEGF) injections. Adjuvant therapies that further reduce edema may improve vision outcomes. Objective:To compare the short-term effect of topical...

journal_title：JAMA ophthalmology

authors： Hsu J,Patel SN,Wolfe JD,Shah CP,Chen E,Jenkins TL,Wibbelsman TD,Obeid A,Mikhail M,Garg SJ,Ho AC,Chiang A,Spirn MJ,Vander JF

更新日期：2020-05-01 00:00:00

abstract：IMPORTANCE:Binocular summation (BiS) is defined as the superiority of visual function for binocular over monocular viewing. Binocular summation decreases with age and large interocular differences in visual acuity. To our knowledge, BiS has not heretofore been well studied as a functional measure of binocularity in str...

journal_title：JAMA ophthalmology

authors： Pineles SL,Velez FG,Isenberg SJ,Fenoglio Z,Birch E,Nusinowitz S,Demer JL

更新日期：2013-11-01 00:00:00

abstract：Importance:Medical and surgical interventions for glaucoma are effective only if they are affordable to patients. Little is known about how affordable glaucoma interventions are in developing and developed countries. Objective:To compare the prices of topical glaucoma medications, laser trabeculoplasty, and trabeculec...

journal_title：JAMA ophthalmology

authors： Zhao PY,Rahmathullah R,Stagg BC,Almobarak F,Edward DP,Robin AL,Stein JD

更新日期：2018-11-01 00:00:00

abstract：Importance:A precise phenotypic characterization of retinal dystrophies is needed for disease modeling as a basis for future therapeutic interventions. Objective:To compare genotype, phenotype, and structural changes in patients with rod-cone dystrophy (RCD) associated with mutations in PDE6A or PDE6B. Design, Settin...

journal_title：JAMA ophthalmology

authors： Khateb S,Nassisi M,Bujakowska KM,Méjécase C,Condroyer C,Antonio A,Foussard M,Démontant V,Mohand-Saïd S,Sahel JA,Zeitz C,Audo I

更新日期：2019-06-01 00:00:00

abstract：IMPORTANCE:We define a Reading Accessibility Index for evaluating reading in individuals with normal and low vision. OBJECTIVE:To compare the Reading Accessibility Index with data from the Impact of Cataracts on Mobility (ICOM) study. DESIGN, SETTING, AND PARTICIPANTS:This investigation was a secondary data analysis ...

journal_title：JAMA ophthalmology

authors： Calabrèse A,Owsley C,McGwin G,Legge GE

更新日期：2016-04-01 00:00:00

abstract：IMPORTANCE:Accurate assessment of disease burden and determination of disease progression are challenging in dry age-related macular degeneration (AMD). We assessed the utility of quantified fundus autofluorescence in (FAF) the evaluation and follow-up of dry AMD. OBJECTIVE:To develop a method for quantitative FAF ima...

journal_title：JAMA ophthalmology

authors： Schachar IH,Zahid S,Comer GM,Stem M,Schachar AG,Saxe SJ,Gardner TW,Elner VM,Jayasundera T

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE:To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and...

journal_title：JAMA ophthalmology

authors： Gliem M,Müller PL,Finger RP,McGuinness MB,Holz FG,Charbel Issa P

更新日期：2016-07-01 00:00:00

abstract：Importance:The coronavirus disease 2019 pandemic illustrates the increasingly important role of telemedicine as a method of clinician-patient interaction. However, electronic applications (apps) for the testing of ophthalmology vital signs, such as visual acuity, can be published and used without any verification of ac...

journal_title：JAMA ophthalmology

authors： Steren BJ,Young B,Chow J

更新日期：2021-01-14 00:00:00

abstract：:Within 20 years of its discovery 100 years ago, vitamin A was recognized as critical to normal eyes, growth, and survival. Clinical interest subsequently contracted to its importance in preventing xerophthalmia, until this ophthalmologist stumbled, quite accidently, on its role in fighting life-threatening infections....

journal_title：JAMA ophthalmology

authors： Sommer A

更新日期：2014-01-01 00:00:00

abstract：IMPORTANCE:We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of glaucoma. We report the intraocular pressure (IOP)-lowering effects and safety of K-115 based on our results. OBJECTIVE:To study the IOP-...

journal_title：JAMA ophthalmology

authors： Tanihara H,Inoue T,Yamamoto T,Kuwayama Y,Abe H,Araie M,K-115 Clinical Study Group.

更新日期：2013-10-01 00:00:00

abstract：Importance:The ocular surface is continuously exposed to the environment. Although studies have focused on associations between outdoor environmental conditions and dry eye, information on associations between the indoor environment and dry eye is lacking. Objective:To determine associations between the indoor environ...

journal_title：JAMA ophthalmology

authors： Huang A,Janecki J,Galor A,Rock S,Menendez D,Hackam AS,Jeng BH,Kumar N

更新日期：2020-08-01 00:00:00

abstract：Importance:The frequency of anti-vascular endothelial growth factor (VEGF) injections has grown exponentially with the introduction of bevacizumab, ranibizumab, and most recently aflibercept. The cost associated with these medications has garnered significant national attention, warranting a granular analysis of their ...

journal_title：JAMA ophthalmology

authors： Berkowitz ST,Sternberg P Jr,Feng X,Chen Q,Patel S

更新日期：2019-06-20 00:00:00

abstract：IMPORTANCE:Acanthamoeba keratitis is a debilitating eye disease that requires effective topical drug therapy. Currently, there is no standard in vitro test to evaluate anti-Acanthamoeba drugs. OBJECTIVE:To develop a practical in vitro complete-kill assay to assess anti-Acanthamoeba drugs. DESIGN AND SETTING:Isolates ...

journal_title：JAMA ophthalmology

authors： Kowalski RP,Abdel Aziz S,Romanowski EG,Shanks RM,Nau AC,Raju LV

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Few studies have been published on the association of the radiation dose received to the eyes during radiotherapy (RT) for childhood cancer and the risk for later cataract. OBJECTIVE:To investigate the risk for cataract after treatment of nonretinoblastoma solid cancer in childhood. DESIGN, SETTING, AND PA...

journal_title：JAMA ophthalmology

authors： Allodji RS,Diallo I,El-Fayech C,Kahlouche A,Dumas A,Schwartz B,Oberlin O,Benadjaoud MA,Labbé M,Jackson A,Bullet J,Rubino C,Haddy N,De Vathaire F

更新日期：2016-04-01 00:00:00

abstract：IMPORTANCE:The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process. OBJECTIVES:To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomog...

journal_title：JAMA ophthalmology

authors： Piri N,Nesmith BL,Schaal S

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE:Myopia (nearsightedness) has its onset in childhood and affects about one-third of adults in the United States. Along with its high prevalence, myopia is expensive to correct and is associated with ocular diseases that include glaucoma and retinal detachment. OBJECTIVE:To determine the best set of predictor...

journal_title：JAMA ophthalmology

authors： Zadnik K,Sinnott LT,Cotter SA,Jones-Jordan LA,Kleinstein RN,Manny RE,Twelker JD,Mutti DO,Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group.

更新日期：2015-06-01 00:00:00

abstract：IMPORTANCE:The Standard of Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study showed that intravitreal triamcinolone acetonide (IVTA) is effective at reducing macular edema and improving visual acuity in participants with retinal vein occlusion. Secondary analysis of the incidence, risk factors, and timing...

journal_title：JAMA ophthalmology

authors： Aref AA,Scott IU,Oden NL,Ip MS,Blodi BA,VanVeldhuisen PC,SCORE Study Investigator Group.

更新日期：2015-09-01 00:00:00

abstract：Importance:Given the estimates of increasing prevalence of myopia, especially in Asia, it is important to determine the current prevalence of myopia among populations of schoolchildren in Japan. Objective:To investigate the current prevalence rate of myopia and the association between environmental factors and myopia ...

journal_title：JAMA ophthalmology

authors： Yotsukura E,Torii H,Inokuchi M,Tokumura M,Uchino M,Nakamura K,Hyodo M,Mori K,Jiang X,Ikeda SI,Kondo S,Negishi K,Kurihara T,Tsubota K

更新日期：2019-08-15 00:00:00

abstract：:IMPORTANCE Advanced glycation end products have been implicated in the pathogenesis of age-related macular degeneration (AMD). OBJECTIVE To investigate the relationship between serum carboxymethyllysine (CML), a major circulating advanced glycation end product, and AMD in older adults. DESIGN, SETTING, AND PARTICIPANT...

journal_title：JAMA ophthalmology

authors： Semba RD,Cotch MF,Gudnason V,Eiríksdottir G,Harris TB,Sun K,Klein R,Jonasson F,Ferrucci L,Schaumberg DA

更新日期：2014-04-01 00:00:00

abstract：Importance:The comparative clinical effectiveness of ranibizumab, aflibercept, and bevacizumab for the management of macular edema due to central retinal vein occlusion (CRVO) is unclear. Objective:To determine whether intravitreal aflibercept or bevacizumab compared with ranibizumab results in a noninferior mean chan...

journal_title：JAMA ophthalmology

authors： Hykin P,Prevost AT,Vasconcelos JC,Murphy C,Kelly J,Ramu J,Hounsome B,Yang Y,Harding SP,Lotery A,Chakravarthy U,Sivaprasad S,LEAVO Study Group.

更新日期：2019-08-29 00:00:00

abstract：Importance:Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs. Identification of pharmacogenetic associations may help clinicians understand the mechanisms underlying this variability a...

journal_title：JAMA ophthalmology

authors： Lorés-Motta L,Riaz M,Grunin M,Corominas J,van Asten F,Pauper M,Leenders M,Richardson AJ,Muether P,Cree AJ,Griffiths HL,Pham C,Belanger MC,Meester-Smoor MA,Ali M,Heid IM,Fritsche LG,Chakravarthy U,Gale R,McKibbin M,

更新日期：2018-08-01 00:00:00

abstract：Importance:Certain features of the lamina cribrosa may be associated with increased risk of glaucoma progression. Objectives:To compare the rates of retinal nerve fiber layer (RNFL) thinning in patients with open-angle glaucoma with or without lamina cribrosa (LC) defects and to evaluate factors associated with the ra...

journal_title：JAMA ophthalmology

authors： Moghimi S,Zangwill LM,Manalastas PIC,Suh MH,Penteado RC,Hou H,Hasenstab K,Ghahari E,Bowd C,Weinreb RN

更新日期：2019-04-01 00:00:00

abstract：Importance:Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include inflammation of the skin, ...

journal_title：JAMA ophthalmology

authors： Thomas M,Armenti ST,Ayres MB,Demirci H

更新日期：2018-05-01 00:00:00

abstract：IMPORTANCE:A large number of genes can cause inherited retinal degenerations when mutated. It is important to identify the cause of disease for a better disease prognosis and a possible gene-specific therapeutic intervention. OBJECTIVE:To identify the cause of disease in families with nonsyndromic retinitis pigmentosa...

journal_title：JAMA ophthalmology

authors： Shevach E,Ali M,Mizrahi-Meissonnier L,McKibbin M,El-Asrag M,Watson CM,Inglehearn CF,Ben-Yosef T,Blumenfeld A,Jalas C,Banin E,Sharon D

更新日期：2015-03-01 00:00:00

abstract：Importance:Glaucoma-related adverse events constitute serious complications of cataract removal in infancy, yet long-term data on incidence and visual outcome remain lacking. Objective:To identify and characterize incident cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among childr...

journal_title：JAMA ophthalmology

authors： Freedman SF,Beck AD,Nizam A,Vanderveen DK,Plager DA,Morrison DG,Drews-Botsch CD,Lambert SR,Infant Aphakia Treatment Study Group.

更新日期：2020-12-17 00:00:00