Preventing blindness and saving lives: the centenary of vitamin A.

abstract：Importance:To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. Objective:To develop and evaluate a set of diagnostic criteria for VKH disease using data from Chinese patients. Design, Setting, and Participants:This case-control stud...

journal_title：JAMA ophthalmology

authors： Yang P,Zhong Y,Du L,Chi W,Chen L,Zhang R,Zhang M,Wang H,Lu H,Yang L,Zhuang W,Yang Y,Xing L,Feng L,Jiang Z,Zhang X,Wang Y,Zhong H,Jiang L,Zhao C,Li F,Cao S,Liu X,Chen X,Shi Y,Zhao W,Kijlstra A

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of selective laser trabeculoplasty (SLT) for the treatment of primary open-angle glaucoma in an African-derived population in the developing world. METHODS:Sixty-one subjects from St. Lucia with medically treated primary open-angle glaucoma underwent a 30-day washout, followed by bil...

journal_title：JAMA ophthalmology

authors： Realini T

更新日期：2013-03-01 00:00:00

abstract：Importance:The comparative clinical effectiveness of ranibizumab, aflibercept, and bevacizumab for the management of macular edema due to central retinal vein occlusion (CRVO) is unclear. Objective:To determine whether intravitreal aflibercept or bevacizumab compared with ranibizumab results in a noninferior mean chan...

journal_title：JAMA ophthalmology

authors： Hykin P,Prevost AT,Vasconcelos JC,Murphy C,Kelly J,Ramu J,Hounsome B,Yang Y,Harding SP,Lotery A,Chakravarthy U,Sivaprasad S,LEAVO Study Group.

更新日期：2019-08-29 00:00:00

abstract：IMPORTANCE:Patients and clinicians need to accurately assess the risks and benefits of pars plana vitrectomy for proliferative diabetic retinopathy, but clinical trial data may not reflect real-world experience. OBJECTIVE:To prospectively audit the complications of vitrectomy for proliferative diabetic retinopathy and...

journal_title：JAMA ophthalmology

authors： Jackson TL,Johnston RL,Donachie PH,Williamson TH,Sparrow JM,Steel DH

更新日期：2016-01-01 00:00:00

abstract：Importance:Some eyes with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent intravitreal anti-vascular endothelial growth factor (VEGF) injections. Adjuvant therapies that further reduce edema may improve vision outcomes. Objective:To compare the short-term effect of topical...

journal_title：JAMA ophthalmology

authors： Hsu J,Patel SN,Wolfe JD,Shah CP,Chen E,Jenkins TL,Wibbelsman TD,Obeid A,Mikhail M,Garg SJ,Ho AC,Chiang A,Spirn MJ,Vander JF

更新日期：2020-05-01 00:00:00

abstract：IMPORTANCE:Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE:To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and...

journal_title：JAMA ophthalmology

authors： Gliem M,Müller PL,Finger RP,McGuinness MB,Holz FG,Charbel Issa P

更新日期：2016-07-01 00:00:00

abstract：IMPORTANCE:Superior rectus transposition (SRT) with or without medial rectus recession (MRc) has been introduced as an alternative to MRc alone for treatment of esotropic Duane syndrome; however, the effectiveness of these procedures has not been compared previously. OBJECTIVE:To compare the safety and efficacy of MRc...

journal_title：JAMA ophthalmology

authors： Yang S,MacKinnon S,Dagi LR,Hunter DG

更新日期：2014-06-01 00:00:00

abstract：Importance:Most premature infants will not develop retinopathy of prematurity (ROP) of clinical relevance, yet screening evaluations often continue beyond hospital discharge, even for those infants without ROP. Objectives:To identify the characteristics of infants at low risk for ROP, for whom further postdischarge sc...

journal_title：JAMA ophthalmology

authors： Wade KC,Ying GS,Baumritter A,Gong A,Kemper AR,Quinn GE,e-ROP Cooperative Group.

更新日期：2019-02-01 00:00:00

abstract：IMPORTANCE:The clinical features of the follicular subtype of ocular adnexal lymphoma (OAL) have not been previously evaluated in a large cohort. OBJECTIVE:To characterize the clinical features of follicular OAL. DESIGN, SETTING, AND PARTICIPANTS:We performed a retrospective multicenter study that involved 6 eye canc...

journal_title：JAMA ophthalmology

authors： Rasmussen PK,Coupland SE,Finger PT,Graue GF,Grossniklaus HE,Honavar SG,McKelvie P,Mulay K,Prause JU,Ralfkiaer E,Sjö LD,Heegaard S

更新日期：2014-07-01 00:00:00

abstract：IMPORTANCE:This study confirmed the long-term outcomes of the ZB5M phakic intraocular lens (PIOL). OBJECTIVE:To evaluate the potential long-term risk associated with ZB5M PIOL implantation. DESIGN, SETTING, AND PARTICIPANTS:A retrospective, nonrandomized, consecutive cohort study of a total of 208 eyes implanted with...

journal_title：JAMA ophthalmology

authors： Alio JL,Abbouda A,Peña-Garcia P,Huseynli S

更新日期：2013-12-01 00:00:00

abstract：Importance:Despite the existing country-specific strategies tackling social inequalities in visual health in adults, little is known about trends in visual function in childhood and its association with social position. Objective:To investigate the distribution of childhood visual function in the United Kingdom and as...

journal_title：JAMA ophthalmology

authors： Bountziouka V,Cumberland PM,Rahi JS

更新日期：2017-09-01 00:00:00

abstract：IMPORTANCE:Medication persistence is an important factor for treatment effect in patients with glaucoma. Evaluating risk factors for refill discontinuation might be helpful for improving persistence and preventing blindness in patients with glaucoma. OBJECTIVES:To estimate the persistence rate with topical glaucoma me...

journal_title：JAMA ophthalmology

authors： Hwang DK,Liu CJ,Pu CY,Chou YJ,Chou P

更新日期：2014-12-01 00:00:00

abstract：IMPORTANCE:Acanthamoeba keratitis is a debilitating eye disease that requires effective topical drug therapy. Currently, there is no standard in vitro test to evaluate anti-Acanthamoeba drugs. OBJECTIVE:To develop a practical in vitro complete-kill assay to assess anti-Acanthamoeba drugs. DESIGN AND SETTING:Isolates ...

journal_title：JAMA ophthalmology

authors： Kowalski RP,Abdel Aziz S,Romanowski EG,Shanks RM,Nau AC,Raju LV

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Although anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration (AMD) results in improved vision overall, loss of substantial vision can occur. Understanding the processes that lead to loss of vision may lead to preventive strategies. OBJECTIVE:To determine the inc...

journal_title：JAMA ophthalmology

authors： Ying GS,Kim BJ,Maguire MG,Huang J,Daniel E,Jaffe GJ,Grunwald JE,Blinder KJ,Flaxel CJ,Rahhal F,Regillo C,Martin DF,CATT Research Group.

更新日期：2014-08-01 00:00:00

abstract：Importance:The frequency of anti-vascular endothelial growth factor (VEGF) injections has grown exponentially with the introduction of bevacizumab, ranibizumab, and most recently aflibercept. The cost associated with these medications has garnered significant national attention, warranting a granular analysis of their ...

journal_title：JAMA ophthalmology

authors： Berkowitz ST,Sternberg P Jr,Feng X,Chen Q,Patel S

更新日期：2019-06-20 00:00:00

abstract：Importance:Uveitis has been associated with psoriatic arthritis, but to our knowledge, the relationship between uveitis and psoriasis is unsettled among researchers. Objective:To evaluate the risk of incident uveitis among people with psoriasis. Design, Setting, and Participants:This nationwide, retrospective cohort ...

journal_title：JAMA ophthalmology

authors： Chi CC,Tung TH,Wang J,Lin YS,Chen YF,Hsu TK,Wang SH

更新日期：2017-05-01 00:00:00

abstract：IMPORTANCE:Patching has been a mainstay in treating unilateral congenital cataract. However, its efficacy has not been rigorously assessed. OBJECTIVE:To examine the association between patching and visual acuity in a cohort of children treated for unilateral congenital cataract. DESIGN, SETTING, AND PARTICIPANTS:This...

journal_title：JAMA ophthalmology

authors： Drews-Botsch C,Celano M,Cotsonis G,Hartmann EE,Lambert SR,Infant Aphakia Treatment Study Group.

更新日期：2016-08-01 00:00:00

abstract：Importance:Because studies have suggested that atropine might slow the progression of myopia in children, randomized clinical trials are warranted to understand this potential causal relationship. Objective:To evaluate the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongat...

journal_title：JAMA ophthalmology

authors： Wei S,Li SM,An W,Du J,Liang X,Sun Y,Zhang D,Tian J,Wang N

更新日期：2020-10-01 00:00:00

abstract：IMPORTANCE:Accurate diagnosis of choroidal melanoma is challenging and has important implications for both physicians and patients. We assessed the utility of quantification of fundus autofluorescence in the evaluation and follow-up of choroidal nevomelanocytic tumors. OBJECTIVE:To assess the utility of autofluorescen...

journal_title：JAMA ophthalmology

authors： Albertus DL,Schachar IH,Zahid S,Elner VM,Demirci H,Jayasundera T

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:The optic disc pit (ODP) has been considered a region of localized susceptibility to the damage of glaucoma. OBJECTIVE:To determine whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the presence and structural characteristics of an ODP in primary open-angle glaucoma. DESIGN...

journal_title：JAMA ophthalmology

authors： Lee SH,Lee EJ,Kim TW

更新日期：2015-10-01 00:00:00

abstract：Objective:To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. Design, Setting, and Participants:The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India ...

journal_title：JAMA ophthalmology

authors： Prajna NV,Krishnan T,Rajaraman R,Patel S,Srinivasan M,Das M,Ray KJ,O'Brien KS,Oldenburg CE,McLeod SD,Zegans ME,Porco TC,Acharya NR,Lietman TM,Rose-Nussbaumer J,Mycotic Ulcer Treatment Trial II Group.

更新日期：2016-12-01 00:00:00

abstract：IMPORTANCE:Few studies have been published on the association of the radiation dose received to the eyes during radiotherapy (RT) for childhood cancer and the risk for later cataract. OBJECTIVE:To investigate the risk for cataract after treatment of nonretinoblastoma solid cancer in childhood. DESIGN, SETTING, AND PA...

journal_title：JAMA ophthalmology

authors： Allodji RS,Diallo I,El-Fayech C,Kahlouche A,Dumas A,Schwartz B,Oberlin O,Benadjaoud MA,Labbé M,Jackson A,Bullet J,Rubino C,Haddy N,De Vathaire F

更新日期：2016-04-01 00:00:00

abstract：Importance:The US Food and Drug Administration's medical device regulatory pathway was initially conceived with hardware devices in mind. The emerging market for ophthalmic digital devices necessitates an evolution of this paradigm. Objectives:To facilitate innovation in ophthalmic digital health with attention to saf...

journal_title：JAMA ophthalmology

authors： Bodnar ZM,Schuchard R,Myung D,Tarver ME,Blumenkranz MS,Afshari NA,Humayun MS,Morse C,Nischal K,Repka MX,Sprunger D,Trese M,Eydelman MB

更新日期：2019-06-06 00:00:00

abstract：Importance:Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include inflammation of the skin, ...

journal_title：JAMA ophthalmology

authors： Thomas M,Armenti ST,Ayres MB,Demirci H

更新日期：2018-05-01 00:00:00

abstract：Importance:Both primary and secondary forms of childhood glaucoma have many distinct causative mechanisms, and in many cases a cause is not immediately clear. The broad phenotypic spectrum of secondary glaucoma, particularly in individuals with variants in FOXC1 or PITX2 genes associated with Axenfeld-Rieger syndrome, ...

journal_title：JAMA ophthalmology

authors： Siggs OM,Souzeau E,Pasutto F,Dubowsky A,Smith JEH,Taranath D,Pater J,Rait JL,Narita A,Mauri L,Del Longo A,Reis A,Chappell A,Kearns LS,Staffieri SE,Elder JE,Ruddle JB,Hewitt AW,Burdon KP,Mackey DA,Craig JE

更新日期：2019-04-01 00:00:00

abstract：Importance:Macular edema (ME) is the leading cause of decreased visual acuity (VA) associated with retinal vein occlusion (RVO). Identifying factors associated with better outcomes in RVO eyes treated with anti-vascular endothelial growth factor (VEGF) therapy may provide information useful in counseling patients. Obj...

journal_title：JAMA ophthalmology

authors： Scott IU,VanVeldhuisen PC,Ip MS,Blodi BA,Oden NL,King J,Antoszyk AN,Peters MA,Tolentino M,SCORE2 Investigator Group.

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:We define a Reading Accessibility Index for evaluating reading in individuals with normal and low vision. OBJECTIVE:To compare the Reading Accessibility Index with data from the Impact of Cataracts on Mobility (ICOM) study. DESIGN, SETTING, AND PARTICIPANTS:This investigation was a secondary data analysis ...

journal_title：JAMA ophthalmology

authors： Calabrèse A,Owsley C,McGwin G,Legge GE

更新日期：2016-04-01 00:00:00

abstract：IMPORTANCE:Myopia (nearsightedness) has its onset in childhood and affects about one-third of adults in the United States. Along with its high prevalence, myopia is expensive to correct and is associated with ocular diseases that include glaucoma and retinal detachment. OBJECTIVE:To determine the best set of predictor...

journal_title：JAMA ophthalmology

authors： Zadnik K,Sinnott LT,Cotter SA,Jones-Jordan LA,Kleinstein RN,Manny RE,Twelker JD,Mutti DO,Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group.

更新日期：2015-06-01 00:00:00

abstract：Importance:Anti-vascular endothelial growth factor (anti-VEGF) is a breakthrough treatment for wet age-related macular degeneration (wAMD), the most common cause of blindness in western countries. Anti-VEGF treatment prevents vision loss and has been shown to produce vision gains lasting as long as 5 years. Although th...

journal_title：JAMA ophthalmology

authors： Mulligan K,Seabury SA,Dugel PU,Blim JF,Goldman DP,Humayun MS

更新日期：2019-11-14 00:00:00

abstract：IMPORTANCE:The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 no...

journal_title：JAMA ophthalmology

authors： Schaumberg DA,Rose L,DeAngelis MM,Semba RD,Hageman GS,Chasman DI

更新日期：2014-01-01 00:00:00