Abstract:
Importance:Because studies have suggested that atropine might slow the progression of myopia in children, randomized clinical trials are warranted to understand this potential causal relationship. Objective:To evaluate the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongation in Chinese children. Design, Setting, and Participants:This was a randomized, placebo-controlled, double-masked study. A total of 220 children aged 6 to 12 years with myopia of -1.00 D to -6.00 D in both eyes were enrolled between April 2018 and July 2018 at Beijing Tongren Hospital, Beijing, China. Cycloplegic refraction and axial length were measured at baseline, 6 months, and 12 months. Adverse events were also recorded. Interventions:Patients were randomly assigned in a 1:1 ratio to atropine, 0.01%, or placebo groups to be administered once nightly to both eyes for 1 year. Main Outcomes and Measures:Mean changes and percentage differences in myopia progression and axial elongation between atropine, 0.01%, or placebo groups. Results:Of 220 participants, 103 were girls (46.8%), and the mean (SD) age was 9.64 (1.68) years. The mean (SD) baseline refractive error and axial length were -2.58 (1.39) D and 24.59 (0.87) mm. Follow-up at 1 year included 76 children (69%) and 83 children (75%) allocated into the atropine, 0.01%, and placebo groups, respectively, when mean myopia progression was -0.49 (0.42) D and -0.76 (0.50) D in the atropine, 0.01%, and placebo groups (mean difference, 0.26 D; 95% CI, 0.12-0.41 D; P < .001), with a relative reduction of 34.2% in myopia progression. The mean (SD) axial elongation in the atropine, 0.01%, group was 0.32 (0.19) mm compared with 0.41 (0.19) mm in the placebo group (mean difference, 0.09 mm; 95% CI, 0.03-0.15 mm; P = .004), with relative reduction of 22.0% in axial elongation. Fifty-one percent and 13.2% of children progressed by at least 0.50 D and 1.00 D in the atropine, 0.01%, group, compared with 69.9% and 34.9% in the placebo group. No serious adverse events related to atropine were reported. Conclusions and Relevance:While the clinical relevance of the results cannot be determined from this trial, these 1-year results, limited by approximately 70% follow-up, suggest that atropine, 0.01%, eyedrops can slow myopia progression and axial elongation in children and warrant future studies to determine longer-term results and potential effects on slowing sight-threatening pathologic changes later in life. Trial Registration:http://www.chictr.org.cn Identifier: ChiCTR-IOR-17013898.
journal_name
JAMA Ophthalmoljournal_title
JAMA ophthalmologyauthors
Wei S,Li SM,An W,Du J,Liang X,Sun Y,Zhang D,Tian J,Wang Ndoi
10.1001/jamaophthalmol.2020.3820subject
Has Abstractpub_date
2020-10-01 00:00:00eissn
2168-6165issn
2168-6173pii
2771170pub_type
杂志文章abstract:Importance:To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. Objective:To develop and evaluate a set of diagnostic criteria for VKH disease using data from Chinese patients. Design, Setting, and Participants:This case-control stud...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
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abstract:IMPORTANCE:To date, only a few studies have directly compared nonpenetrating surgery (NPS) and trabeculectomy (TE). Therefore, there is no strong evidence as to which surgical technique leads to the best results in terms of ocular hypotensive effect and safety. OBJECTIVE:To compare the hypotensive effect and safety of...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamaophthalmol.2013.5059
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:JAMA ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamaophthalmol.2013.7623
更新日期:2014-03-01 00:00:00
abstract:Importance:Uveitis has been associated with psoriatic arthritis, but to our knowledge, the relationship between uveitis and psoriasis is unsettled among researchers. Objective:To evaluate the risk of incident uveitis among people with psoriasis. Design, Setting, and Participants:This nationwide, retrospective cohort ...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
abstract:Importance:Many ophthalmology appointments have been converted to telemedicine assessments. The use of a printed vision chart for ophthalmology telemedicine appointments that can be used by people who are excluded from digital testing has yet to be validated. Objectives:To evaluate the repeatability of visual acuity m...
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更新日期:2021-01-07 00:00:00
abstract:Importance:Congenital stationary night blindness (CSNB) implies a stable condition, with the major symptom being nyctalopia present at birth. Pediatric clinical presentation and the course of different genetic subtypes of CSNB have not, to our knowledge, been well described in the era of molecular genetic diagnosis. O...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2018.0185
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of WINROP (https://winrop.com), an algorithm based on serial measurements of neonatal body weight to predict proliferative retinopathy of prematurity (ROP), in a Korean population of preterm infants. METHODS:The records of preterm infants with gestational age less than 32 weeks wh...
journal_title:JAMA ophthalmology
pub_type: 杂志文章
doi:10.1001/jamaophthalmol.2013.566
更新日期:2013-01-01 00:00:00
abstract:IMPORTANCE:We define a Reading Accessibility Index for evaluating reading in individuals with normal and low vision. OBJECTIVE:To compare the Reading Accessibility Index with data from the Impact of Cataracts on Mobility (ICOM) study. DESIGN, SETTING, AND PARTICIPANTS:This investigation was a secondary data analysis ...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1001/jamaophthalmol.2015.6097
更新日期:2016-04-01 00:00:00
abstract:Importance:A precise phenotypic characterization of retinal dystrophies is needed for disease modeling as a basis for future therapeutic interventions. Objective:To compare genotype, phenotype, and structural changes in patients with rod-cone dystrophy (RCD) associated with mutations in PDE6A or PDE6B. Design, Settin...
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
abstract:IMPORTANCE:There is a major lack of randomized controlled clinical trials evaluating the efficacy of prismatic treatments for hemianopia. Evidence for their effectiveness is mostly based on anecdotal case reports and open-label evaluations without a control condition. OBJECTIVE:To evaluate the efficacy of real relativ...
journal_title:JAMA ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamaophthalmol.2013.5636
更新日期:2014-02-01 00:00:00
abstract:Importance:Optical coherence tomographic angiography (OCT-A) is able to visualize retinal microvasculature without the need for injection of fluorescein contrast dye. Nevertheless, it is only able to capture a limited view of macula and does not show leakage. Objectives:To evaluate the retinal microvasculature using O...
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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doi:10.1001/jamaophthalmol.2017.6787
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-18 00:00:00
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更新日期:2013-09-01 00:00:00
abstract:Importance:Given the rarity of posterior uveal melanoma in patients younger than 21 years, reporting clinical experience in this area has relevance. Objective:To describe the baseline clinical features, treatment, and clinical course of a group of patients younger than 21 years who have primary posterior uveal melanom...
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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更新日期:2015-08-01 00:00:00
abstract:Importance:The coronavirus disease 2019 pandemic illustrates the increasingly important role of telemedicine as a method of clinician-patient interaction. However, electronic applications (apps) for the testing of ophthalmology vital signs, such as visual acuity, can be published and used without any verification of ac...
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pub_type: 杂志文章
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更新日期:2021-01-14 00:00:00
abstract:IMPORTANCE:The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 no...
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pub_type: 杂志文章,meta分析,随机对照试验
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更新日期:2014-01-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-07 00:00:00
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更新日期:2017-09-01 00:00:00